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211.

The Effects of Intracellular Monocarboxylates on the ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes

NariKim, JinHan, Eui-YongKim, Won-KyungHo, YungE.Earm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 6 581-589 (9 pages)

NariKim, JinHan, Eui-YongKim, Won-KyungHo, YungE.Earm 저
...
- 3,000원
at room temperature. Intracellular application of acetate, formate and pyruvate led to an inhibition of channel activity, whereas intracellular application of lactate increased channel activity. These effects were reversible upon washout. Analysis of single channel kinetics showed that monocarboxylates did not affect open-time constant and close-time constant. These results suggest that monocarboxylates participate in modulating KATP channels activity in cardiac cells and that modulation of KATP...
212.

Effect of the Inhibition of Platelet Activating Factor on Oxidative Lung Injury Induced by Interleukin-1α

YoungManLeeYoon-YubPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 10 479-491 (13 pages)

YoungManLeeYoon-YubPark 저
...
- 4,200원
In order to know the pathogenesis of adult respiratory distress syndrome (ARDS) in association with the oxidative stress by neutrophils, the role of platelet activating factor (1-0-alkyl-2-acetyl-sn- glycero-3-phosphocholine, PAF) was investigated during acute lung injury induced by interleukin- 1α (IL-1) in rats. An insufflation of IL-1 into the rat's trachea increased the acetyltransferase activity in the lung and the increase of PAF content was followed. As evidences of acute lung injury by...
213.

Inhibitory Effect of Caffeine on Carbachol-Induced Nonselective Cationic Current in Guinea-Pig Gastric Myocytes

SungJoonKim, KyungWanMin, YoungChulKim, SangJinLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 10 353-359 (7 pages)

SungJoonKim, KyungWanMin, YoungChulKim, SangJinLee, InsukSo, KiWhanKim 저
...
- 3,000원
In gastrointestinal smooth muscle, muscarinic stimulation by carbachol (CCh) activates nonselective cation channel current (ICCh) which is facilitated by intracellular [Ca2⁢] increase. Caffeine is widely used in experiments to mobilize Ca2⁢ from intracellular stores. This study shows a strong inhibitory effect of caffeine on ICCh in guinea-pig gastric myocyte. In this study, the underlying mechanism of the inhibitory effect of caffeine was investigated. ICCh was completely...
214.

Modulation of Outward Potassium Currents by Nitric Oxide in Longitudinal Smooth Muscle Cells of Guinea-pig Ileum

Seong-ChunKwon, SeJoongRim, Bok-SoonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 11 225-232 (8 pages)

Seong-ChunKwon, SeJoongRim, Bok-SoonKang 저
...
- 3,000원
To investigate the possible involvement of outward potassium (K+) currents in nitric oxide-induced relaxation in intestinal smooth muscle, we used whole-cell patch clamp technique in freshly dispersed guinea-pig ileum longitudinal smooth muscle cells. When cells were held at ⁣60 mV and depolarized from ⁣40 mV to ⁢50 mV in 10 mV increments, sustained outward K+ currents were evoked. The outward K+ currents were markedly increased by the addition of 10 ㄍM sodium...
215.

Pharmacological Evidence that Cromakalim Inhibits Ca2+ Release from Intracellular Stores in Porcine Coronary Artery

ByungYongRhim, SunHwaHong, ChiDaeKim, WonSukLee, KiWhanHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 4 27-34 (8 pages)

ByungYongRhim, SunHwaHong, ChiDaeKim, WonSukLee, KiWhanHong 저
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- 3,000원
In the present study, it was aimed to further indentify the intracellular action mechansm of cromakalim and levcromakalim in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine caused an increase in intracellular free Ca2⁢ ([Ca2⁢]i) in association with a contraction in a concentration-dependent manner. Cromakalim (1 ㄍM) caused a reduction in acetylcholine-induced increased [Ca2⁢]i not only in the mormal...
216.

한국인 정신분열병과 HLA-DRB1 대립유전자의 관련성

황나영, 김종원, 오흥범, 조지희, 오선영, 홍진표, 박종익, 이동은 대한신경정신의학회 신경정신의학 9 Pages

대한신경정신의학회 신경정신의학 2000, 제 39권 제 5호 9 889-897 (9 pages)

황나영, 김종원, 오흥범, 조지희, 오선영, 홍진표, 박종익, 이동은 저
...
- 3,000원
연구목적： 유전이 정신분열병의 중요한 원인이라는 것은 널리 인정되어 왔다. 본 연구는 한국인 정신분열병과 HLADRB1 유전자좌와의 관련성을 알아보고 외국인 대상의 보고들과 비교함으로써 한국인 정신분열병의 유전적 특성을 밝히고자 시행하였다. 방 법： 정신분열병 환자 70명을 대상으로 HLA-DRB1 대립유전자를 고해상도 수준까지 분석하였다. 저해상도 수 준의 HLA-DR 결과는 정상 한국인 2,000명의 연구 보고와 비교하였으며 고해상도 수준의 HLA-DRB1 결과는 정상 한국인 229명의 연구 보고와 비교하였다. 결 과： 저해상도...
217.

정신분열병 가계에서 6p24-22 염색체에 대한 연관 분석

박동연, 이유상, 장용이, 조은영, 전현옥, 박해정, 김종원, 김창현, 이동수, 홍경수 대한신경정신의학회 신경정신의학 7 Pages

대한신경정신의학회 신경정신의학 2006, 제 45권 제 5호 2 411-417 (7 pages)

박동연, 이유상, 장용이, 조은영, 전현옥, 박해정, 김종원, 김창현, 이동수, 홍경수 저
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- 3,000원
218.

Reduced Protein Denaturation in Thermotolerant Cells by Elevated Levels of HSP70

한미영(Mi Young Han), 박영미(Young-Mee Park) 대한약리학회 대한약리학잡지 11 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 15 433-443 (11 pages)

한미영(Mi Young Han), 박영미(Young-Mee Park) 저
...
- 4,000원
We describe a novel approach to evaluate quantitatively the amounts of denatured proteins in cells upon heat exposure. A thiol compound, diamide [azodicarboxylic acid bis (dimethylamide)] causes protein cross-linking with exposed sulfyhydryl residues of denatured proteins. Since denatured proteins expose normally well-hidden sulfhydryl groups, these will be preferentially cross-linked by diamide. Thus diamide acts to trap denatured proteins. We observed that protein aggregates (high molecular...
219.

Oxidative Stress and HSP70 Expression Upon Cerebral Isehemia-Reperfusion in Mongolian Gerbil

박영미(Young-Mee Park), 김철훈(Chul-Hoon Kim), 도윤정(Yun-Jeong Do), 최은미(Eun-Mi Choi), 안영수(Young-Soo Ahn) 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 3호 5 335-346 (12 pages)

박영미(Young-Mee Park), 김철훈(Chul-Hoon Kim), 도윤정(Yun-Jeong Do), 최은미(Eun-Mi Choi), 안영수(Young-Soo Ahn) 저
...
- 4,100원
A critical role of oxygen-derived free radicals has been implicated in ischemia/reperfusion (I/R)-induced brain damage. In this study, we have produced experimental I/R to the brains of Mongolian gerbil (Meriones unguiculatus) by a transient occlusion and release of the common carotid arteries. We have attempted to determine whether the oxidative stress is generated upon I/R and whether this oxidative stress is linked to the cell damage. Since hippocampus has been suggested as one of the most...
220.

뱀 (파충류) 골격근 소포체 칼슘유리 채널

남장현(Jang Hyeon Nam), 석정호(Jeong Ho Seok) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1996, 제 32권 제 1호 7 57-66 (10 pages)

남장현(Jang Hyeon Nam), 석정호(Jeong Ho Seok) 저
...
- 3,000원
파충류 골격근의 근소포체에서 칼슘유리 채널의 존재를 밝히고저 뱀 골격근에서 근소포체를 분리하여 SDS-PAGE 전기영동, RyR의 정제, [3H]ryanodine 결합실험 및 45Ca 유리 실험으로 아래와 같은 결과를 얻었다. 1) 뱀골격근 소포체도 단일 band의 high molecular weight 단백을 가지고 있고, 그 mobility는 포유류 골격근의 것과 유사했다. 2) RyR의 정제과정에서 얻어진 [3H]ryanodine의 peak 결합 분획에서 high molecular weight의 단백분획이 발견되었다. 3) 뱀 골격근 SR vesicles에 대한 [3H]ryanodine의 maximum binding site와...

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