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The Effects of Astragalus Membranaceus on Repeated Restraint Stress-induced Biochemical and Behavioral Responses
Hyun-JungPark, HyunYoungKim, Kun-HoYoon, KyungSooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 8 315-319 (5 pages)
Astragalus Membranaceus (AM) is a useful Korean herb that has been clinically prescribed for stress-related illness. The objective of the present study was to examine the anti-stress effects of AM on repeated stress-induced alterations of anxiety, learning and memory in rats. Restraint stress was administered for 14 days (2h/day) and AM (400mg/kg) given by oral administration, in the AM group, for the same period. Starting on the eighth day, the rats were tested for spatial memory on the Morris... -
A Simple Method for Predicting Hippocampal Neurodegeneration in a Mouse Model of Transient Global Forebrain Ischemia
Kyung-OkCho, Seul-KiKim, Young-JinCho, Ki-WugSung, SeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 1 167-172 (6 pages)
In the present study, we developed a simple method to predict the neuronal cell death in the mouse hippocampus and striatum following transient global forebrain ischemia by evaluating both cerebral blood flow and the plasticity of the posterior communicating artery (PcomA). Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral occlusion of the common carotid artery (BCCAO) for 30 min. The regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry. The... -
Melittin-induced Nociceptive Responses are Alleviated by Cyclooxygenase-1 Inhibitor
JoohyunKim, HongKeeShin, KyungHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 8 45-50 (6 pages)
Melittin-induced pain model has been known to be very useful for the study of pain mechanism. Melittin-induced nociceptive responses are reported to be modulated by the changes in the activity of excitatory amino acid receptor, calcium channel, spinal serotonin receptor and extracellular signaling-regulated kinase. The present study was undertaken to investigate the role of cyclooxygenase (COX) in the melittin-induced nociception. Changes in mechanical threshold, flinchings and paw thickness... -
Vibrio vulnificus Cytolysin Forms Anion-selective Pores on the CPAE Cells, a Pulmonary Endothelial Cell Line
Bok-HeeChoi, Byung-HyunPark, Yong-GeunKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 4 259-264 (6 pages)
Cytolysin produced by Vibrio vulnificus has been incriminated as one of the important virulence determinants in V. vulnificus infection. Ion selectivity of cytolysin-induced pores was examined in a CPAE cell, a cell line of pulmonary endothelial cell, using inside-out patch clamp techniques. In symmetrical NaCl concentration (140 mM), intracellular or extracellular application of cytolysin formed ion-permeable pores with a single channel conductance of 37.5⁑4.0 pS. The pore currents were... -
Normal Anxiety, Fear and Depression-related Behaviors in Mice Lacking α-Calcitonin Gene-Related Peptide
JonghoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 4 299-304 (6 pages)
Calcitonin gene-related peptide (CGRP) expressing neurons are distributed widely throughout the central and peripheral nervous systems. Due to its distribution and pharmacological studies, CGRP has been implicated to be involved in anxiety, fear and depression. In this study, αCGRP-knockout mice were used to assess the consequences of removing this neuropeptide to the mice behaviors. αCGRP-knockout mice performed equally as well as wild type mice in the light-dark transition test and in the... -
Effects of Kanagawa Hemolysin on Blood Pressure and Arterial Tone in Rats
YoungMoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 8 225-233 (9 pages)
while the iv KH-depressor effect was not. Simultaneous icv administration of the three agents (ouabain, diltiazem, or bumetanide: 10μg/kg each) significantly reduced the pressor effect. The icv KH-pressor effect was inhibited by treatment with iv phentolamine or chlorisondamine, but was not affected by iv candesartan. The iv KH-depressor effect was repeatable and was attenuated by treatment with iv NAME or methylene blue. In vitro experiments using isolated thoracic aorta, 106 M... -
한국청소년 음주 및 약물남용과 비행행동간의 상관관계
김헌수, 김현실 대한신경정신의학회 신경정신의학 14 Pages
대한신경정신의학회 신경정신의학 2002, 제 41권 제 3호 10 472-485 (14 pages)
연구목적: 청소년 음주 및 약물남용과 비행행동간의 상관관계 및 관련 제 변수간의 경로를 규명함으로써 향후 청소 년의 비행·범죄행동 중재 프로그램 개발을 위한 기초자료를 제시하기 위함이다. 방 법: 본 연구는 횡단적(cross sectional), 대단위 실태조사(mass survey)연구이며 연구 대상으로는 비례층 화 표본추출법을 적용하여 학생청소년 1,192명과 비행·범죄 청소년 843명을 선정하였다. 본 연구에 서는 비행행동의 원인요인을 규명하기 위하여 비행행동을 종속변수로 음주(Ⅰ, Ⅱ), 흡연 및 약물남용 을 매개변수로... -
소아청소년 정신의학에서의 동물모델
이서경, 반건호 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 2007, 제 46권 제 4호 2 285-294 (10 pages)
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Mental Disorders In The Korean Rural Communities
Petrus Suckjin Yoo 대한신경정신의학회 신경정신의학 19 Pages
대한신경정신의학회 신경정신의학 1962, 제 1권 제 1호 2 9-27 (19 pages)
이 논문은 학국농어촌 6개지역 (開井, 黑山島,安井, 茂来, 鏡浦, 坡州)의 주민 총 11,974명에 대하여 시행한 정 신병의 조사결과를 검토, 분석히•여 보고한것이다. 조사기간은 1956〜1960년의 5년간이 었다. 조사방법은 Brugger( 獨), Stroemgren(丁) , Uc3dmura( 日), Lin (中)둥이 각각 자기나라에서, 같은 조사에 사용하였던 일제조사” 방법에 의거하였다. 조사대상 총인구중 166명, 즉 1.38%가 정신질환자로 진단되었다. . 그중 주요정신병 만은 93명으로 조사대상 총인구의 0.77%에 해당된다. 발견된 전체... -
신경행동학적 인지상태검사의 임상적용을 위한 연구 ᅳ 60세 이상의 연령군을 대상으로 一
김창윤, 이광원, 박인호 대한신경정신의학회 신경정신의학 14 Pages
대한신경정신의학회 신경정신의학 1994, 제 33권 제 6호 13 1329-1342 (14 pages)


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