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2251.

Comparison of Ectopic Gene Expression Methods in Rat Neural Stem Cells

WoosukKim, JiHyeonKim, Sun-YoungKong, Min-HyePark, UyDongSohn, Hyun-JungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 4 23-30 (8 pages)

WoosukKim, JiHyeonKim, Sun-YoungKong, Min-HyePark, UyDongSohn, Hyun-JungKim 저
...
- 3,000원
Neural stem cells (NSCs) have the ability to proliferate and differentiate into various types of cells that compose the nervous system. To study functions of genes in stem cell biology, genes or siRNAs need to be transfected. However, it is difficult to transfect ectopic genes into NSCs. Thus to identify the suitable method to achieve high transfection efficiency, we compared lipid transfection, electroporation, nucleofection and retroviral transduction. Among the methods that we tested, we...
2252.

Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1b in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 11 447-453 (7 pages)

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 저
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- 3,000원
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to understand mechanisms of action of TLR6 in inflammatory responses, we investigated the effects of FSL-1, the TLR6 ligand, on expression of chemokine CCL2 and cytokine IL-1Ղ and determined cellular factors involved in FSL-1-mediated expression of CCL2 and IL-1Ղ in mononuclear cells. Exposure of human monocytic...
2253.

Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures

YeonJooJung, EunChengSuh, KyungEunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 8 423-429 (7 pages)

YeonJooJung, EunChengSuh, KyungEunLee 저
...
- 3,000원
Brain ischemia leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors, referred as excitotoxicity, which mediates neuronal cell death. However, less attention has been paid to changes in synaptic activity and morphology that could have an important impact on cell function and survival following ischemic insult. In this study, we investigated the effects of reperfusion after oxygen/glucose deprivation (OGD) not only upon neuronal cell death, but also on ultrastructural and biochemical...
2254.

CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model

Jong-SunYoo, Yun-JungLee, JooWonYoon, KyeongEunHyung, KwangWooHwang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 10 349-353 (5 pages)

Jong-SunYoo, Yun-JungLee, JooWonYoon, KyeongEunHyung, KwangWooHwang 저
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- 1,500원
Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the inhibitory function of CTLA-4 may be attractive in settings of undesirable T cell responses such as autoimmunity or transplant rejection. We have tested the hypothesis that transgenic constitutive expression of CTLA-4 can further attenuate immune responses when compared with normal...
2255.

The Effect of Methanol on the Structural Parameters of Neuronal Membrane Lipid Bilayers

Hyung-JinJoo, Shin-HoAhn, Hang-RaeLee, Sung-WooJung, Chang-WonChoi, Min-SeokKim, Moon-KyoungBae, In-KyoChung, Soo-KyoungBae, Hye-OckJang, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 5 255-264 (10 pages)

Hyung-JinJoo, Shin-HoAhn, Hang-RaeLee, Sung-WooJung, Chang-WonChoi, Min-SeokKim, Moon-KyoungBae, In-KyoChung, Soo-KyoungBae, Hye-OckJang, 저
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- 3,000원
The structures of the intact synaptosomal plasma membrane vesicles (SPMVs) isolated from bovine cerebral cortexs, and the outer and the inner monolayer separately, were evaluated with 1,6-diphenyl- 1,3,5-hexatriene (DPH) and 1,3-di(1-pyrenyl)propane (Py-3-Py) as fluorescent reporters and trinitrophenyl groups as quenching agents. The methanol increased bulk rotational and lateral mobilities of SPMVs lipid bilayers. The methanol increased the rotational and lateral mobilities of the outer...
2256.

Morphologic Evidence of Anti-Tumor Specificity of T Cells Activated by Denritic Cells Derived from Peripheral Blood Mononuclear Cells of Thyroid Cancer Patients

Dae-HeuiLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 3 243-247 (5 pages)

Dae-HeuiLee 저
...
- 1,500원
Recent studies suggest that immunization with autologous dendritic cells (DCs) results in protective immunity and rejection of established tumors in various human malignancies. The purpose of this study is to determine whether DCs are generated from peripheral blood mononuclear cells (PBMNs) by using cytokines such as F1t-3 ligand (FL), granulocyte macrophage-colony stimulating factor (GM-CSF), IL-4, and TNF-Ձ, and whether cytotoxic T cells activated against the thyroid cancer tissues by...
2257.

Inhibitory Actions of HERG Currents by the Immunosuppressant Drug Cyclosporin A

SeungHoLee, SangJuneHahn, GyesikMin, JimokKim, Su-HyunJo, HanChoe, BokHeeChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 7 291-298 (8 pages)

SeungHoLee, SangJuneHahn, GyesikMin, JimokKim, Su-HyunJo, HanChoe, BokHeeChoi 저
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- 3,000원
The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC50 value and a Hill coefficient of 3.17ՌM and 0.89, respectively. Pretreatment with cypermethrine, a calcineurin inhibitor, had no effect on the CsA-induced inhibition of the HERG channel. The...
2258.

CD40 Co-stimulation Inhibits Sustained BCR-induced Ca2＋ Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells

YenHoangNguyen, Ki-YoungLee, TaeJinKim, SungJoonKim, TongMookKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 9 179-187 (9 pages)

YenHoangNguyen, Ki-YoungLee, TaeJinKim, SungJoonKim, TongMookKang 저
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- 3,000원
Regulation of B cell receptor (BCR)-induced Ca2＋ signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature WEHI-231 cells to Ձ-IgM antibody (0.5∼48 hr), the initial transient decrease in BCR-induced [Ca2＋]i was followed by spontaneous recovery to control level within 24 hr. The recovery of Ca2＋ signaling in WEHI-231 cells was not due to restoration of internalized...
2259.

Myoplasmic [Ca2＋], Crossbridge Phosphorylation and Latch in Rabbit Bladder Smooth Muscle

Young-DonKim, Min-HyungCho, Seong-ChunKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 8 171-177 (7 pages)

Young-DonKim, Min-HyungCho, Seong-ChunKwon 저
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- 3,000원
Tonic smooth muscle exhibit the latch phenomenon: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and cellular activation in phasic smooth muscle are unknown. The present study was to determine whether Ca2＋-stimulated MRLC phosphorylation could suffice to explain the agonist- or high K＋-induced contraction in a fast, phasic smooth muscle. We measured myoplasmic [Ca2＋], MRLC...
2260.

Characterization and Immunopotentiating Effects of the Glycoprotein Isolated from Dioscorea Batatas

PhamThiThuHuong, Chan-HoLee, MeiHongLi, MinYoungLee, Joon-KiKim, Sun-MeeLee, Jong-HeumSeon, Dong-CheolLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 5 101-106 (6 pages)

PhamThiThuHuong, Chan-HoLee, MeiHongLi, MinYoungLee, Joon-KiKim, Sun-MeeLee, Jong-HeumSeon, Dong-CheolLee, YoungJinJeon 저
...
- 3,000원
We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages, lymphocytes, neutrophils, and monocytes into the peritoneal cavity. Treatment of spleen cells isolated from C57BL/6 mice with GDB significantly increased the proliferation of B cells and T cells induced by LPS and ConA,...

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