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221.

Ellagic acid plays a protective role against UV-B-induced oxidative stress by up-regulating antioxidant components in human dermal fibroblasts

BeomyeolBaek, SuHeeLee, KyunghoonKim, Hye-WonLim, Chang-JinLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 6 269-277 (9 pages)

BeomyeolBaek, SuHeeLee, KyunghoonKim, Hye-WonLim, Chang-JinLim 저
...
- 3,000원
Ellagic acid (EA), an antioxidant polyphenolic constituent of plant origin, has been reported to possess diverse pharmacological properties, including anti-inflammatory, anti-tumor and immunomodulatory activities. This work aimed to clarify the skin anti-photoaging properties of EA in human dermal fibroblasts. The skin anti-photoaging activity was evaluated by analyzing the reactive oxygen species (ROS), matrix metalloproteinase-2 (MMP-2), total glutathione (GSH) and superoxide dismutase (SOD)...
222.

Brief low [Mg2+]o-induced Ca2+ spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons

HeeJungKim, JiSeonYang, ShinHeeYoon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 13 101-109 (9 pages)

HeeJungKim, JiSeonYang, ShinHeeYoon 저
...
- 3,000원
Reducing [Mg2+]o to 0.1 mM can evoke repetitive [Ca2+]i spikes and seizure activity, which induces neuronal cell death in a process called excitotoxicity. We examined the issue of whether cultured rat hippocampal neurons preconditioned by a brief exposure to 0.1 mM [Mg2+]o are rendered resistant to excitotoxicity induced by a subsequent prolonged exposure and whether Ca2+ spikes are involved in this process. Preconditioning by an exposure to 0.1 mM [Mg2+]o for 5 min inhibited significantly...
223.

The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling

SungRyulLee, SuJinNoh, JuliusRyanPronto, YuJeongJeong, HyoungKyuKim, InSungSong, ZhelongXu, HyogYoungKwon, SeChanKang, Eun-HwaSohn, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 1 389-400 (12 pages)

SungRyulLee, SuJinNoh, JuliusRyanPronto, YuJeongJeong, HyoungKyuKim, InSungSong, ZhelongXu, HyogYoungKwon, SeChanKang, Eun-HwaSohn, KyungS 저
...
- 4,100원
Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn2+) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc’s critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and...
224.

Improvement Characteristics of Bio-active Materials Coated Fabric on Rat Muscular Mitochondria

DongheeLee, Young-WonKim, Jung-HaKim, MisukYang, HyemiBae, InjaLim, HyoweonBang, Kyung-ChanGo, Gwang-WungYang, Yong-HwanRho, Hyo-SukPark, E 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 14 283-289 (7 pages)

DongheeLee, Young-WonKim, Jung-HaKim, MisukYang, HyemiBae, InjaLim, HyoweonBang, Kyung-ChanGo, Gwang-WungYang, Yong-HwanRho, Hyo-SukPark, E 저
...
- 3,000원
This study surveys the improvement characteristics in old-aged muscular mitochondria by bio-active materials coated fabric (BMCF). To observe the effects, the fabric (10 and 30%) was worn to old-aged rat then the oxygen consumption efficiency and copy numbers of mitochondria, and mRNA expression of apoptosis- and mitophagy-related genes were verified. By wearing the BMCF, the oxidative respiration significantly increased when using the 30% materials coated fabric. The mitochondrial DNA copy...
225.

p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts

JinKyungSeok, YongChoolBoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 8 241-247 (7 pages)

JinKyungSeok, YongChoolBoo 저
...
- 3,000원
examined whether SFN released from UVB-irradiated epidermal keratinocytes increases MMP1 release from dermal fibroblasts, and whether these events are affected by p-coumaric acid (p-CA), a natural phenolic compound with UVB-shielding and antioxidant properties. HaCaT cells were exposed to UVB in the absence and presence of p-CA, and the conditioned medium was used to stimulate fibroblasts in medium transfer experiments. The cells and media were analyzed to determine the expressions/releases of...
226.

Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model

LiQinZhu, JianWeiYang, YuanZhang, YongMingWang, JianLeiZhang, YuanYuanZhao, WeiLinDong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 3 99-104 (6 pages)

LiQinZhu, JianWeiYang, YuanZhang, YongMingWang, JianLeiZhang, YuanYuanZhao, WeiLinDong 저
...
- 3,000원
The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intra- abdominal infected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profiles in various tissues in intra-abdominal infected human. 12 male rats with intra- abdominal infections, induced by Escherichia coli, received a single dose of 40 mg/kg body weight of moxifloxacin. Blood plasma was collected at 5, 10, 20, 30, 60, 120, 240, 480, 1440 min after drug injection. A PBPK...
227.

ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells

YuSeokSong, MarieCarmelBalcos, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Myo-KyoungKim, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 5 29-34 (6 pages)

YuSeokSong, MarieCarmelBalcos, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Myo-KyoungKim, Dong-SeokKim 저
...
- 3,000원
Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeo-phyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not...
228.

TRPV1 in Salivary Gland Epithelial Cells Is Not Involved in Salivary Secretion via Transcellular Pathway

SeulkiChoi, Yong-HwanShin, EunNamkoong, Sung-MinHwang, XinCong, GuangyanYu, KyungpyoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 12 525-530 (6 pages)

SeulkiChoi, Yong-HwanShin, EunNamkoong, Sung-MinHwang, XinCong, GuangyanYu, KyungpyoPark 저
...
- 3,000원
Transient receptor potential vanilloid subtype 1 (TRPV1) was originally found in sensory neurons. Recently, it has been reported that TRPV1 is expressed in salivary gland epithelial cells (SGEC). However, the physiological role of TRPV1 in salivary secretion remains to be elucidated. We found that TRPV1 is expressed in mouse and human submandibular glands (SMG) and HSG cells, originated from human submandibular gland ducts at both mRNA and protein levels. However, capsaicin (CAP), TRPV1 agonist,...
229.

Transient Receptor Potential C4/5 Like Channel Is Involved in Stretch-Induced Spontaneous Uterine Contraction of Pregnant Rat

SeungsooChung, Young-HwanKim, Ji-HyunJoeng, Duck-SunAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 9 503-508 (6 pages)

SeungsooChung, Young-HwanKim, Ji-HyunJoeng, Duck-SunAhn 저
...
- 3,000원
Spontaneous myometrial contraction (SMC) in pregnant uterus is greatly related with gestational age and growing in frequency and amplitude toward the end of gestation to initiate labor. But, an accurate mechanism has not been elucidated. In human and rat uterus, all TRPCs except TRPC2 are expressed in pregnant myometrium and among them, TRPC4 are predominant throughout gestation, suggesting a possible role in regulation of SMC. Therefore, we investigated whether the TRP channel may be involved...
230.

Fucoidan Promotes the Reconstruction of Skin Equivalents

YuSeokSong, HailanLi, MarieCarmelBalcos, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Hye-RyungChoi, Kyoung-ChanPark, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 7 327-331 (5 pages)

YuSeokSong, HailanLi, MarieCarmelBalcos, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Hye-RyungChoi, Kyoung-ChanPark, Dong-SeokKim 저
...
- 1,500원
SE. Immunohistochemical staining showed that the addition of fucoidan to dermal equivalents in-creased expression of proliferating cell nuclear antigen (PCNA) and p63. In addition, expression of α6-integrin was significantly increased by fucoidan, whereas expression of β1-integrin, type 1 collagen, elastin, fibronectin did not markedly change. These results suggest that fucoidan has positive effects on epidermal reconstruction and will therefore be beneficial in the reconstruction of SE.

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