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221.

G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle

UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)

UyDongSohn, DongSeokKim, KarnamSMurthy 저
...
- 4,000원
Contraction of smooth muscle is initiated by an increase in cytosolic Ca2⁢ leading to activation of Ca2⁢/ calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of Ca2⁢ and the kinetic of Ca2⁢ mobilization. Ca2⁢ mobilizing agonists stimulate different...
222.

DAMGO, a μ-Opioid Agonist and Cholecystokinin-Octapeptide Have Dual Modulatory Effects on Capsaicin-Activated Current in Rat Dorsal Root Ganglion Neurons

Su-YongEun, JimokKim, JihyeLee, SungJunJung, JooMinPark, YunKyungPark, DongkwanKim, SangJeongKim, JiyeonKwak, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 10 71-78 (8 pages)

Su-YongEun, JimokKim, JihyeLee, SungJunJung, JooMinPark, YunKyungPark, DongkwanKim, SangJeongKim, JiyeonKwak, JunKim 저
...
- 3,000원
Capsaicin, a pungent ingredient of hot pepper, elicits an intense burning pain when applied cutaneously and intradermally. Activation of capsaicin-gated channel in C-type dorsal root ganglion (DRG) neurons produces nonselective cationic currents. Although electrophysiological and biochemical properties of capsaicin-activated current (ICAP) were studied, the regulatory mechanism and intracellular signaling pathway are still unclear. In the present study, we investigated the modulations of ICAP...
223.

Amperozide Decreases Cocaine-Induced Increase in Behavior and Immediate Early Gene Expression in the Dorsal Striatum

EunSangChoeJongYeonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 4 361-367 (7 pages)

EunSangChoeJongYeonKim 저
...
- 3,000원
Cocaine functions as indirect dopamine and serotonin (5-hydroxytryptamine, 5HT) agonists and induces genomic and behavioral alterations in the striatum. Previously we demonstrated that ritanserin, a 5HT2/1C receptor antagonist, is not responsible for cocaine-induced behavioral alterations and zif268 mRNA gene expression in the striatum (see the previous paper in this issue). In this study, it was hypothesized that dopamine and 5HT2/1C receptors are required for cocaine-induced behavioral...
224.

Ritanserin, a 5HT2/1C Receptor Antagonist, Does Not Block Cocaine- Induced Behavioral Alterations and zif268 mRNA Expression in the Striatum of the Rats

EunSangChoeJongYeonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 3 355-359 (5 pages)

EunSangChoeJongYeonKim 저
...
- 1,500원
Cocaine induces immediate early gene expression and behavioral changes by blocking dopamine transporters in the terminals of nigrostriatal neurons in the striatum. The pharmacological role of serotonin 2/1C (5HT2/1C) receptors in cocaine-induced expression of zif268 (NGFI-A, egr1 and Krox-24) mRNA, a member of the zinc finger, was investigated using quantitative in situ hybridization histochemistry in vivo. Behavioral alterations induced by cocaine were also monitored in relation with blockade...
225.

The Role of K+ Channels on Spontaneous Action Potential in Rat Clonal Pituitary GH3 Cell Line

HyewhonRhim, Hye-JungBaek, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 1 81-90 (10 pages)

HyewhonRhim, Hye-JungBaek, Won-KyungHo, YungEEarm 저
...
- 3,000원
The types of K⁢ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary GH3 cells. Heterogeneous pattern of SAP activities was changed into more regular mode with elongation of activity duration and afterhyperpolarization by treatment of TEA (10 mM). Under this condition, exposure of the class III antiarrhythmic agent E-4031...
226.

Effect of Propofol, an Intravenous Anesthetic Agent, on KATP Channels of Pancreatic β-cells in Rats

EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 4 25-31 (7 pages)

EunJeePark, Dae-KyuSong, JaeKyuCheun, JungInBae, Won-KyungHo, YungEEarm 저
...
- 3,000원
ATP-sensitive potassium channels (KATP channels) play an important role in insulin secretion from pancreatic beta cells. We have investigated the effect of propofol on KATP channels in cultured single pancreatic beta cells of rats. Channel activity was recorded from membrane patches using the patch-clamp technique. In the inside-out configuration bath-applied propofol inhibited the KATP channel activities in a dose-dependent manner. The half-maximal inhibition dose (ED50) was 48.6⁑8.4μM...
227.

Effect of Capsaicin on Delayed Rectifier K+ Current in Adult Rat Dorsal Root Ganglion Neurons

JunghyunHahn, SungkwonChung, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 2 9-14 (6 pages)

JunghyunHahn, SungkwonChung, HyoweonBang 저
...
- 3,000원
K⁢ currents play multiple roles in the excitability of dorsal root ganglion (DRG) neurons. Influences on these currents change the shape of the action potential, its firing threshold and the resting membrane potential. In this study, whole cell configuration of patch clamp technique had been applied to record the blocking effect of capsaicin, a lipophilic alkaloid, on the delayed rectifier K⁢ current in cultured small diameter DRG neurons of adult rat. Capsaicin reduced the...
228.

Roles of Ca2+-Activated K+ Conductances on Spontaneous Firing Patterns of Isolated Rat Medial Vestibular Nucleus Neurons

SangWooChun, JaeWooJun, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 1 1-8 (8 pages)

SangWooChun, JaeWooJun, ByungRimPark 저
...
- 3,000원
To investigate the contributions of intrinsic membrane properties to the spontaneous activity of medial vestibular nucleus (MVN) neurons, we assessed the effects of blocking large and small calcium-activated potassium channels by means of patch clamp recordings. Almost all the MVN neurons recorded in neonatal (P13∼P17) rat were shown to have either a single deep after-hyperpolarization (AHP; type A cells), or an early fast and a delayed slow AHP (type B cells). Among the recorded MVN cells,...
229.

Spectral Analysis of Heart Rate Variability during Passive Standing after Ethanol Ingestion

HyeongJinKim, ChunDukHan, EunKyoungYang, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 9 605-613 (9 pages)

HyeongJinKim, ChunDukHan, EunKyoungYang, WonJungLee 저
...
- 3,000원
The purpose of the present study was to evaluate cardiovascular regulation during passive standing (PS) after ethanol ingestion by spectral analysis of heart rate variability (HRV) in flushed and nonflushed subjects. Of 24 young male subjects, 8 belonged to flushed group (F) and 16 to nonflushed group (NF). Two sessions of 10-min PS were performed before and after ethanol (0.5 g/kg) ingestion. Powers of R-R interval variability in very low frequency (VLF, 0∼0.05 Hz), low frequency (LF,...
230.

Effect of Prostaglandins D2, E2 and I2 on the Regulation of KATP Channel Activity in Rat Cardiac Myocytes

Jeong-MinJu, Seung-YeolNah, Jae-HaKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 7 507-512 (6 pages)

Jeong-MinJu, Seung-YeolNah, Jae-HaKim 저
...
- 3,000원
Contribution of prostaglandins D2, E2 and I2 (PGD2, PGE2 and PGI2) on the regulation of ATP-sensitive K⁢ channel (KATP channel) was investigated in isolated single rat ventricular cardiac myocytes using the patch clamp technique. PGD2, PGE2 and PGI2 did not affect KATP channel activity in the inside-out patch, but increased channel activity in a dose-dependent manner when the channel activities were attenuated by the administration of 100 μM ATP to the internal solution in the inside-out...

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