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221.

NADPH Oxidase and Mitochondrial ROS are Involved in the TNF-α-induced Vascular Cell Adhesion Molecule-1 and Monocyte Adhesion in Cultured Endothelial Cells

JaeHyeonYu, CukSeongKim, DaeGoonYoo, YunJeongSong, HeeKyoungJoo, GunKang, JiYoonJo, JinBongPark, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 9 217-221 (5 pages)

JaeHyeonYu, CukSeongKim, DaeGoonYoo, YunJeongSong, HeeKyoungJoo, GunKang, JiYoonJo, JinBongPark, ByeongHwaJeon 저
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- 1,500원
Atherosclerosis is considered as a chronic inflammatory process. However, the nature of the oxidant signaling that regulates monocyte adhesion and its underlying mechanism is poorly understood. We investigated the role of reactive oxygen species on the vascular cell adhesion molecule-1 (VCAM-1) and monocyte adhesion in the cultured endothelial cells. TNF-α at a range of 1~30 ng/ml induced VCAM-1 expression dose-dependently. BCECF-AM-labeled U937 cells firmly adhered on the surface of...
222.

Modulation of Large Conductance Ca2+-activated K+ Channel of Skin Fibroblast (CRL-1474) by Cyclic Nucleotides

JihyunYun, SeungtaeKim, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 9 131-134 (4 pages)

JihyunYun, SeungtaeKim, HyoweonBang 저
...
- 1,500원
Potassium channels in human skin fibroblast have been studied as a possible site of Alzheimer disease pathogenesis. Fibroblasts in Alzheimer disease show alterations in signal transduction pathway such as changes in Ca2⁢ homeostasis and/or Ca2⁢-activated kinases, phosphatidylinositol cascade, protein kinase C activity, cAMP levels and absence of specific K⁢ channel. However, little is known so far about electrophysiological and pharmacological characteristics of...
223.

Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 9 345-350 (6 pages)

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 저
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- 3,000원
Heat shock (43oC for 60 minutes) is sufficient to induce apoptosis in a wide number of cell lines. In this study, we asked whether DNA strand breaks are responsible for this phenomenon. Using the highly sensitive comet assay for DNA damage detection, we were unable to demonstrate DNA breaks immediately after heat shock in Raji human lymphoid cells. It showed that DNA breaks were not necessary for hyperthermic apoptosis, since its activity is indicative of DNA lesions. Here, we present a...
224.

Heterogeneity of the SR-dependent Inward Na+-Ca2+ Exchange Current in the Heavily Ca2+-buffered Rat Ventricular Myocytes

Kyung-BongYoon, Sung-WanAhn, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.2 6 101-110 (10 pages)

Kyung-BongYoon, Sung-WanAhn, ChangMannKo 저
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- 3,000원
Voltage-sensitive release mechanism was pharmacologically dissected from the Ca2⁢-induced Ca2⁢ release in the SR Ca2⁢ release in the rat ventricular myocytes patch-clamped in a whole-cell mode. SR Ca2⁢ release process was monitored by using forward-mode Na⁢-Ca2⁢ exchange after restriction of the interactions between Ca2⁢ from SR and Na⁢-Ca2⁢ exchange within micro-domains with heavy cytosolic Ca2⁢ buffering with 10 mM BAPTA. During...
225.

Inhibitory Effect of Esculetin on the Inducuble Nitric Oxide Synthase Expression in TNF-stimulated 3T3-L1 Adipocytes

Jeong-YehYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.5 7 283-287 (5 pages)

Jeong-YehYang 저
...
- 1,500원
While nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) is beneficial for host survival, it is also detrimental to the host. Thus, regulation of iNOS gene expression may be an effective therapeutic strategy for the prevention of unwanted reactions at various pathologic conditions. During the screening process for the possible iNOS regulators, we observed that esculetin is a potent inhibitor of cytokine-induced iNOS expression. The treatment of 3T3-L1 adipocytes with the tumor...
226.

Changes of Afferent Transmission to the SI Cortex by Transient Co-Stimulation of Receptive Field Center and Outside in Anesthetized Rats

Yu-MiYang, SabinaLim, Chung-KilWon, Hyung-CheulShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 4 27-32 (6 pages)

Yu-MiYang, SabinaLim, Chung-KilWon, Hyung-CheulShin 저
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- 3,000원
We have characterized the aftereffects of impulse activities on the transmission of afferent sensory to the primary somatosensory (SI) cortex of the anesthetized rats (n=22). Following conditioning stimulation (CS, 10 sec, either 5 Hz or 200 Hz) to the receptive field (RF), quantitative determination of the changes of afferent sensory transmission was done by generating post-stimulus time histogram of unit response to the testing stimulation (TS, at 0.5 Hz) to the RF center (RFC) for 60 min. In...
227.

The Reliability and Validity of the Korean Version of the Autism-Spectrum Quotient

Ha-Young Ko, Won-Hye Lee, Eun-Kyung Won, Ji Jeong Ban, Da Eun Jung, Yeni Kim 대한신경정신의학회 Psychiatry Investigation 7 Pages

대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 6 783-789 (7 pages)

Ha-Young Ko, Won-Hye Lee, Eun-Kyung Won, Ji Jeong Ban, Da Eun Jung, Yeni Kim 저
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- 3,000원
Objective_This study was conducted to investigate the reliability and validity of the Korean version of Autism-Spectrum Quotient (AQ). Methods_20 participants with high-functioning autism (HFA) and 99 normal participants were recruited. All participants were completed the AQ and Empathy Quotient (EQ), and parents of the HFA group completed the parent-report AQ. For testing the reliability, we examined Cronbach’s alpha, performed item analysis, and compared self versus parent report score of HFA...
228.

주요 우울증에서 종양괴사인자-베타 유전자의 다형성

전태연, 배치운, 김영호, 장계호, 이정태, 박원명, 김광수 대한신경정신의학회 신경정신의학 8 Pages

대한신경정신의학회 신경정신의학 2000, 제 39권 제 6호 22 1188-1195 (8 pages)

전태연, 배치운, 김영호, 장계호, 이정태, 박원명, 김광수 저
...
- 3,000원
연구목적： 주요 우울증은 역학적 유전연구 등을 통하여 유전적 영향이 높은 것으로 알려져 있으며 최근에는 분자 유 전학적 연구로 유전자 다형성과 질병의 연관성을 밝히는 것이 정신질환의 유전학적 연구에서 중요한 부분을 차지하고 있다. 이에 본 연구는 중추신경계와 면역계간의 상호작용에 관여하는 싸이토카인 중 TNF-β 유 전자의 다형성을 분석하여 주요 우울증과의 유전학적 관련성을 알아보고자 하였다. 방 법： DSM-Ⅳ에 의하여 주요 우울증으로 진단된 95명을 환자군으로 선정하였고 가톨릭조혈모세포정보은행에서 보유하고...
229.

저산소증이 흰쥐 관류부신에서 DMPP, McN-A-343, Excess K+ 및 Ach의 카테콜아민 분비작용에 미치는 영향

임동윤(Dong-Yoon Lim), 허재봉(Jae-Bong Heo), 박유환(Yoo-Han Park) 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1995, 제 31권 제 1호 7 63-74 (12 pages)

임동윤(Dong-Yoon Lim), 허재봉(Jae-Bong Heo), 박유환(Yoo-Han Park) 저
...
- 4,100원
저산소 상태에서는 부신수질로부터 카테콜아민 (CA) 유리작용이 활성화되지만 반면에 소의 배양 chromaffin cell에서는 고통도의 K+에 의한 CA 분비작용이 억제된다고 알려져 있다. 본 연구에서는 적출 흰쥐 관류부신에서 콜린성 자극과 막탈분극에 의한 CA 분비작용에 대한 저산소증의 영향을 검색하고 그 작용기전을 규명코자 하였다. 본 연구목적을 위하여, 적출 흰쥐 관류부신을 이용, 저산소증이 니코틴(N1), 무스카린(M1) 수용체 흥분약, 막탈분극 약물, 칼슘채널 활성화 약물, 세포내 칼슘유리 약물 및 ACh에 의한 CA 분비에...
230.

Carcinogen (3-methyl-4-dimethyl-aminoazo benzene) 처리후 간세포막에서의 Transferrin Receptor 변동에 관한 연구

이재흔(Jae Heun Lee), 노의선(Eu Sun Ro), 허강민(Gang Min Hur), 이충식(Choong Sik Lee), 석정호(Jeong Ho Seok) 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1993, 제 29권 제 1호 9 85-96 (12 pages)

이재흔(Jae Heun Lee), 노의선(Eu Sun Ro), 허강민(Gang Min Hur), 이충식(Choong Sik Lee), 석정호(Jeong Ho Seok) 저
...
- 4,100원
화학물질에 의한 간암 유발과정에서 transferrin receptor (TfR)의 변동을 밝히기 위해 간을 부분절제한 정상백서의 재생간과 발암물질로 3-Me-DAB를 8주간 투여한 백서 또는 약물 투여 후 부분 간절제 수술을 행하여 세포분열을 유도시킨 백서 간조직으로부터 parenchymal cell (PC)과 nonparenchymal cell (NPC)를 분리하고 각각의 세포막을 제조하여 125I-transferrin 결합실험을 실시한 바 다음과 같은 성적을 얻었다. 1. 3-Me-DAB 투여에 의하여 간조직에서 oval cell의 증식, 재생성 변화, 결절형성, 담관의 증식 및 담관세포암...

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