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d-Amphetamine이 백서뇌의 5-HT, 5-HIAA, MAO 및 행동에 미치는 영향에 관한 연구
서유헌(Yoo Hun Suh), 우종인(Jong In Woo)박찬웅(Chan Woong Park) 대한약리학회 대한약리학잡지 16 Pages
대한약리학회 대한약리학잡지 1981, 제 17권 제 2호 6 47-62 (16 pages)
5-HT turnover rate와 MAO 활성도를 측정하였다. 둘째, d-amphetamine, 5-HT 합성을 증가시키는 약물과 합성을 억제시키는 약물을 투여하고, 위의 생화학적 실험과 행동관찰을 병합 실시하여 비교분석하였다. 그 결과는 다음과 같다. 1) d-amphetamine (6 mg/kg)을 급성투여시, 뇌내 5-HT함량이 투여 1시간 후에 최고로(대조치의 123%, p<0.001) 증가되다가 이후 감소하며, 5-HIAA 함량은 처음 15분부터 감소하기 시작하다가 30분에 최저로 떨어지며(대조치의 78%, p<0.005) 이후 증가하여 24시간째는 약간 대조치 이상으로 회복되었다.... -
Cefoperazone(T-1551)의 약리학적 연구
임정규(J.K. Lim), 홍사악(S.A. Hong), 박찬웅(C.W. Park), 김명석(M.S. Kim), 서유헌(Y.H. Suh), 신상구(S.G. Shin), 김용식(Y.S. Kim), 김혜원(H.W. Kim), 이정수(J.S. Lee) 대한약리학회 대한약리학잡지 16 Pages
대한약리학회 대한약리학잡지 1980, 제 16권 제 2호 8 55-70 (16 pages)
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Transepithelial Transport of Organic Cation and Its Inhibition by Sulfhydryl and Carboxyl Reagents in Opossum Kidney Cell Monolayer
Woo, Jae-Suk, Oh, Se-Ok, Jung, Jin-Sup, Kim, Yong-Keun, Lee, Sang-Ho 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 6 53-62 (10 pages)
Transepithelial transport of tetraethylammonium (TEA) was studied in monolayers of opossum kidney cells cultured on permeable membrane filters. [14C]-TEA was transported across the OK cell monolayer from basolateral to apical side by a saturable process which can be stimulated by acidification of the apical medium. The apparent Michaelis-Menten constant (Km) and the maximum velocity(Vmax) for the transport were 41 μM and 147 pmole/ mg protein/ min, respectively. The transport was significantly... -
Transformation of Rabbit Proximal Tubule Cells by Strontium Phosphate Transfection with a Plasmid Containing SV4O Early Region Genes
Han, Ho-Jae, Taub, Mary L., 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 14 233-240 (8 pages)
In this study, it was investigated whether immortalized proximal tubule cells transformed with pRSVT could survive through the numerous passages. Results were as follows: 1. The cells transfected with pRSVT formed rapidly growing, multilayered colonies within 2 weeks in a hormone defined medium. Domes were also observed in some of the cultures. 2. r-glutamyl transpeptidase activity was equivalent to that observed in primary renal proximal tubule cell cultures. 3. Transformed cells with pRSVT... -
Effects of Centrally Administered Angiotensin ll Receptor Antagonists on the Cardiovascular and Hormonal Responses to Hemorrhage in Conscious SHR
Seo, Il-Sook, Yang, Eun-Kyoung, Park, Jae-Sik, Kim, Hyeong-Jin, Lee, Won-Jung 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 10 217-226 (10 pages)
cerebrospinal fluid (aCSF) with or without losartan (DuP 753), a specific Ang ll receptor subtype I (AT1) antagonist and saralasin, a combined AT1/AT2 antagonist was administered into the cerebral lateral ventricle. Hemorrhage was performed at a rate of 3 ml/kg/min far 5 min. Intracerebroventricular administration of losartan and saralasin had no effect on the basal blood pressure. However, in response to acute hemorrhage, central Ang ll antagonists produced a remarkably greater fall in blood... -
Voltage-Dependent Ionic Currents and Their Regulation by GTP and Phorbol Ester in the Unfertilized Eggs of Mouse and Hamster
Kim, Ik-Hyun, Kim, Yang-Mi, Haan, Jae-Hee, Park, Choon-Ok, Hong, Seong-Geun 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 9 93-106 (14 pages)
In addition, the modulatory effect of G proteins and protein kinase C (PKC) on the ionic channels were observed. The inward current in hamster eggs was shown to be due to Ca2+ current (ica)). The current voltage relations of these currents in hamster egg were analogous to those in mouse eggs. The amplitude of ica in the hamster egg was larger than that in the mouse egg (-3.12±1.07 nA vs. -1.71±0.71 nA, mean± SD). These results suggest that the Ca2+ channels in both kinds of eggs have similar... -
Acute and Chronic Effects of Ethanol on the Cardiovascular and Hormonal Responses to Hemorrhage in Conscious Normotensive and Spontaneously Hypertensive Rats
Park, Yoon-Yub, Lee, Joong-Hee, Park, Jae-Sik, Yang, Eun-Kyoung, Ahn, Dong-Kuk, Kim, Hyeong-Jin, Lee, Won-Jung, 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 7 67-78 (12 pages)
(5 ml/kg BW) were tested. In the acute EOH infusion group, hemorrhage was induced 20 min after EOH infusion (1.0 g/kg BW), Baroreceptor reflex sensitivity was assessed by the ratio of changes in hen.1 rate and mean arterial pressure (ΔHR/ΔMAP) immediately after the hemorrhage. Chronic EOH administration elevated MAP in Wistar rats. During acute EOH infusion, MAP do- creased and HR increased in all groups. In comparison to EOH free control rats, acute or chronic EOH treated rats showed a... -
Ventilatory Responses to Continuous Negative Pressure Breathing(CNPB) in Awake Dogs
Cha, Eun-Jong, Goo, Yong-Sook 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 4 37-50 (14 pages)
Ventilatory responses to inhaled CO2 were measured during continuous negative pressure breathing (CNPB) in awake dogs. End expiratory lung volume (EELV) decreased linearly with pressure level during CNPB (correlation coefficient= 0.81, p<0.005) during air breathing. When CNPB was applied during 5% CO2 inhalation, the decrease in EELV was not significantly different (p<0.5) from that during air breathing. As a result of a lowered EELV, tidal volume (VT) significantly decreased by 22% and... -
Short- and Long-term Effects of Potassium on Renin-Aldosterone System in Hypertensive Rats Fed with Different Amounts of Sodium
Kim, Sook-Young, Yang, Eun-Kyung, Park, Jae-Sik, Lee, Won-Jung, Kim, Suhn-Hee 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1991, 제 25권 제 1호 7 69-80 (12 pages)
To evaluate the acute and chronic effects of potassium on aldosterone response to different amounts of sodium intake, two series of experiments were conducted. In the first series of experiments, when the plasma K level was increased acutely by KCI infusion (20 μg/kg/min for 20 min), plasma aldosterone concentration increased in both low Na and high Na groups. However, the aldosterone response to K infusion was significantly greater in the low Na than in the high Na groups. In the second series...


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