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251.

Thiol-dependent Redox Mechanisms in the Modification of ATP-Sensitive Potassium Channels in Rabbit Ventricular Myocytes

JinHan, NariKim, DangVanCuong, ChunghuiKim, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 4 15-23 (9 pages)

JinHan, NariKim, DangVanCuong, ChunghuiKim, EuiyongKim 저
...
- 3,000원
Cellular redox state is known to be perturbed during ischemia and that Ca2⁢ and K⁢ channels have been shown to have functional thiol groups. In this study, the properties of thiol redox modulation of the ATP-sensitive K⁢ (KATP) channel were examined in rabbit ventricular myocytes. Rabbit ventricular myocytes were isolated using a Langendorff column for coronary perfusion and collagenase. Single-channel currents were measured in excised membrane patch configuration of...
252.

Forward-Mode Na+-Ca2+ Exchange during Depolarization in the Rat Ventricular Myocytes with High EGTA

Eun-GiKim, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 5 487-494 (8 pages)

Eun-GiKim, ChangMannKo 저
...
- 3,000원
During depolarization, extrusion of Ca2⁢ from sarcoplasmic reticulum through forward-mode Na⁢-Ca2⁢ exchange was studied in the rat ventricular myocytes patch-clamped in whole-cell configuration. In order to confine the Ca2⁢ responses in a micro-domain by limiting the Ca2⁢ diffusion time, rat ventricular myocytes were dialyzed with high (14 mM) EGTA. K⁢ current was suppressed by substituting KCl with 105 mM CsCl and 20 mM TEA in the pipette filling solution...
253.

Altered Electrophysiological Properties of Coronary Artery in Isoprenaline-Induced Cardiac Hypertrophy

NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 7 413-421 (9 pages)

NariKim, JinHan, EuiyongKim 저
...
- 3,000원
An impaired smooth muscle cell (SMC) relaxation of coronary artery by alteration of K⁢ channels would be the most potential explanation for reduced coronary reserve in left ventricular hypertrophy (LVH), however, this possibility has not been investigated. We performed morphometrical analysis of the coronary artery under electron microscopy and measured Ca2⁢-activated K (KCa) currents and delayed rectifier K (Kdr) currents by whole-cell and inside-out patch-clamp technique in single...
254.

Modulation of Ca2+-Activated Potassium Channels by cGMP- Dependent Signal Transduction Mechanism in Cerebral Arterial Smooth Muscle Cells of the Rabbit

JinHan, NariKim, KwangbokLee, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 2 439-444 (6 pages)

JinHan, NariKim, KwangbokLee, EuiyongKim 저
...
- 3,000원
The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2⁢-activated potassium channel (KCa channel) and is involved in the activation of KCa channel activity in cerebral arterial smooth muscle cells of the rabbit. Single-channel currents were recorded in cell-attached and inside-out patch configurations of patch-clamp techniques. Both molsidomine derivative 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1, 50μM) and...
255.

Relatoinship between Sarcoplasmic Reticular Calcium Release and Na+-Ca2+ Exchange in the Rat Myocardial Contraction

Eun-GiKim, SoonJinKim, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 4 197-210 (14 pages)

Eun-GiKim, SoonJinKim, ChangMannKo 저
...
- 4,300원
Suppressive role of Na⁢-Ca2⁢ exchange in myocardial tension generation was examined in the negative frequency-force relationship (FFR) of electric field stimulated left atria (LA) from postnatal developing rat heart and in the whole-cell clamped adult rat ventricular myocytes with high concentration of intracellular Ca2⁢ buffer (14 mM EGTA). LA twitch amplitudes, which were suppressed by cyclopiazonic acid in a postnatal age-dependent manner, elicited frequency-dependent and...
256.

Responses of Dorsal Horn Neurons to Peripheral Chemical Stimulation in the Spinal Cord of Anesthetized Cats

SungJunJung, JooMinPark, JoonHoLee, JiHyeLee, Su-YongEun, SangJeongKim, Won-IlLim, SunHeeCho, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 3 15-24 (10 pages)

SungJunJung, JooMinPark, JoonHoLee, JiHyeLee, Su-YongEun, SangJeongKim, Won-IlLim, SunHeeCho, JunKim 저
...
- 3,000원
Although nociceptive informations are thought to be processed via different neural mechanisms depending on the types of stimuli, sufficient data have not been accumulated yet. We performed a series of experiments to elucidate the possible neural mechanisms as to chemical stimuli such as formalin, capsaicin and ATP. Single unit activity of wide dynamic range (WDR) neurons and high threshold cells were recorded extracellularly from the lumbosacral enlargement of cat spinal cord before and after...
257.

Opening of ATP-sensitive K+ Channel by Pinacidil Requires Serine/ Threonine Phosphorylation in Rat Ventricular Myocytes

Yong-GeunKwakSoo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 7 293-303 (11 pages)

Yong-GeunKwakSoo-WanChae 저
...
- 4,000원
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K⁢ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches, pinacidil (100 μM) induced the opening of the KATP channel, which was blocked by the pretreatment with H-7 (100 μM) whereas enhanced by the pretreatment with genistein (30 μM) or tyrphostin A23 (10 μM). In inside-out patches, pinacidil...
258.

Dual Action of d-Tubocurarine on Large-Conductance Ca2+-activated K+ Channels from Rat Brain Reconstituted into Planar Lipid Bilayer

SungkwonChungJungHoonShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 2 549-553 (5 pages)

SungkwonChungJungHoonShin 저
...
- 1,500원
Using the planar lipid bilayer method, we investigated the effect of d-tubocurarine (dTC) on the extracellular side of large-conductance Ca2+-activated K+ channel from rat brain. When the initial open probability (Po) of the channel was relatively high, dTC decreased channel activity in a concentration dependent manner. In contrast, when the initial Po was lower, sub-micro molar dTC increased channel activity by destabilizing the closed states of the channel. Further addition of dTC up to micro...
259.

Predicting Working Memory Capacity in Older Subjects Using Quantitative Electroencephalography

Jae Hyuk Shin, Kyungun Jhung, Jae Seok Heo, Suk Kyoon An, Jin Young Park 대한신경정신의학회 Psychiatry Investigation 6 Pages

대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 7 790-795 (6 pages)

Jae Hyuk Shin, Kyungun Jhung, Jae Seok Heo, Suk Kyoon An, Jin Young Park 저
...
- 3,000원
Objective_We utilized a spectral and network analysis technique with an integrated support vector classification algorithm for the automated detection of cognitive capacity using resting state electroencephalogram (EEG) signals. Methods_An eyes-closed resting EEG was recorded in 158 older subjects, and spectral EEG parameters in seven frequency bands, as well as functional brain network parameters were, calculated. In the feature extraction stage, the statistical power of the spectral and...
260.

Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia

Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Kim, Seok Woo Moon, Jae Young 대한신경정신의학회 Psychiatry Investigation 8 Pages

대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 4 767-774 (8 pages)

Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Kim, Seok Woo Moon, Jae Young 저
...
- 3,000원
Objective_Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from the Korean Health Industry Development Institute to investigate the epidemiology, biopsychosocial risk factors, and outcomes of dementia and dementia-related conditions. Methods_The KLOSCAD is the first nationwide multi-center population-based prospective cohort study....

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