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261.

Protective Effect of Defibrotide on Splanchnic Injury following Ischemia and Reperfusion in Rats

SooRanChoi, JiHoonJeong, JinHoSong, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 5 85-94 (10 pages)

SooRanChoi, JiHoonJeong, JinHoSong, YongKyooShin 저
...
- 3,000원
A splanchic artery occlusion for 90 min followed by reperfusion of the mesenteric circulation resulted in a severe form of circulatory shock, characterized by endothelial dysfunction, severe hypotension, marked intestinal tissue injury, and a high mortality rate. The effect of defibrotide, a complex of single-stranded polydeoxyribonucleotides having antithrombotic effect, was investigated in a model of splanchnic artery occlusion (SAO) shock in urethane anesthetized rats. Occlusion of the...
262.

The Effect of Dehydroepiandrosterone on Isoproterenol-induced Cardiomyopathy in Rats

JiHoonJeong, ChanWoongKim, SungHyukYim, YongKyooShin, KyungWhaPark, EonSubPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 4 79-84 (6 pages)

JiHoonJeong, ChanWoongKim, SungHyukYim, YongKyooShin, KyungWhaPark, EonSubPark 저
...
- 3,000원
We evaluated therapeutic and preventive properties of dehydroepiandrosterone (DHEA), a weak androgenic steroid, against isoproterenol-induced cardiomyopathy. The cardiomyopathy was induced by daily i.p. administration of isoproterenol to rats for five days. One group of rats were given with daily s.c. for 5 days during isoproterenol and the other group with daily s.c. DHEA for total 10 days, including 5 days before and during isoproterenol. The animals were killed after each treatment, and...
263.

Open Channel Block of Kv3.1 Currents by Genistein, a Tyrosine Kinase Inhibitor

BokHeeChoi, JiHyunPark, SangJuneHahn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 3 71-78 (8 pages)

BokHeeChoi, JiHyunPark, SangJuneHahn 저
...
- 3,000원
The goal of this study was to analyze the effects of genistein, a widely used tyrosine kinase inhibitor, on cloned Shaw-type K⁢ currents, Kv3.1 which were stably expressed in Chinese hamster ovary (CHO) cells, using the whole-cell configuration of patch-clamp techniques. In whole-cell recordings, genistein at external concentrations from 10 to 100μM accelerated the rate of inactivation of Kv3.1 currents, thereby concentration-dependently reducing the current at the end of depolarizing...
264.

Effects of Zinc on Spontaneous Miniature GABA Release in Rat Hippocampal CA3 Pyramidal Neurons

Byung-JuChoi, Il-SungJang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 1 59-64 (6 pages)

Byung-JuChoi, Il-SungJang 저
...
- 3,000원
The effects of Zn2⁢ on spontaneous glutamate and GABA release were tested in mechanically dissociated rat CA3 pyramidal neurons which retained functional presynaptic nerve terminals. The spontaneous miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs, respectively) were pharmacologically isolated and recorded using whole-cell patch clamp technique under voltage-clamp conditions. Zn2⁢ at a lower concentration (30μM) increased GABAergic mIPSC frequency without...
265.

Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells

DongHeeLee, ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 9 51-57 (7 pages)

DongHeeLee, ChungSooLee 저
...
- 3,000원
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP⁢) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of PC12 cells with MPP⁢ resulted in the nuclear damage, decrease in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive oxygen species (ROS) and depletion of GSH....
266.

Short-Term High Expression of Interferon-Alpha Modulates Progression of Type 1 Diabetes in NOD Mice

Mi-KyoungPark, Su-YeongSeo, Sook-HeeHong, Hye-JinKim, Eun-JinPark, DukKyuKim, Hye-JeongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 7 39-44 (6 pages)

Mi-KyoungPark, Su-YeongSeo, Sook-HeeHong, Hye-JinKim, Eun-JinPark, DukKyuKim, Hye-JeongLee 저
...
- 3,000원
Type I diabetes (T1D) is an organ-specific autoimmune disease caused by the T cell-mediated destruction of the insulin-producing β cells in the pancreatic islets. The onset of T1D is the consequence of a progressive destruction of islet β cells mediated by an imbalance between effector CD4⁢ T helper (Th)1 and regulatory CD4⁢ Th2 cell function. Since interferon-alpha (IFN-α) has been known to modulate immune function and autoimmunity, we investigated whether administration of...
267.

Fluoxetine Modulates Corticostriatal Synaptic Transmission through Postsynaptic Mechanism

HyeongSeokCho, SeJoonChoi, Ki-JungKim, HyunHoLee, YoungJinCho, SeongYunKim, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 6 31-38 (8 pages)

HyeongSeokCho, SeJoonChoi, Ki-JungKim, HyunHoLee, YoungJinCho, SeongYunKim, Ki-WugSung 저
...
- 3,000원
Fluoxetine, widely used for the treatment of depression, is known to be a selective serotonin reuptake inhibitor (SSRI), however, there are also reports that fluoxetine has direct effects on several receptors. Employing whole-cell patch clamp techniques in rat brain slice, we studied the effects of fluoxetine on corticostriatal synaptic transmission by measuring the change in spontaneous excitatory postsynaptic currents (sEPSC). Acute treatment of rat brain slice with fluoxetine (10μM)...
268.

Lysophosphatidylcholine Attenuates Endothelium-dependent Relaxation Responses through Inhibition of ACh-induced Endothelial [Ca2+]i Increase

Seong-ChunKwon, Yong-HoLee, TaicksangNam, Duck-SunAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 5 25-30 (6 pages)

Seong-ChunKwon, Yong-HoLee, TaicksangNam, Duck-SunAhn 저
...
- 3,000원
Lysophosphatidylcholine (LPC), which accumulates in atherosclerotic arteries, has been reported to inhibit endothelium-dependent relaxation (EDR) in many different species. However, the underlying mechanism of LPC-induced inhibition of EDR is still uncertain. In the present study, we measured simultaneously both isometric tension and cytosolic free Ca2⁢ ([Ca2⁢]i) in rabbit carotid strips, and examined the effect of LPC on tension and [Ca2⁢]i. In carotid strips with...
269.

Differential Functional Expression of Clotrimazole-sensitive Ca2+-activated K+ Current in Bal-17 and WEHI-231 Murine B Lymphocytes

HaifengZheng, JaeHongKo, JooHyunNam, YungEEarm, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 4 19-24 (6 pages)

HaifengZheng, JaeHongKo, JooHyunNam, YungEEarm, SungJoonKim 저
...
- 3,000원
The intermediate conductance Ca2⁢-activated K⁢ channels (SK4, IKCa1) are present in lymphocytes, and their membrane expression is upregulated by various immunological stimuli. In this study, the activity of SK4 was compared between Bal-17 and WEHI-231 cell lines which represent mature and immature stages of murine B lymphocytes, respectively. The whole-cell patch clamp with high-Ca2⁢ (0.8μM) KCl pipette solution revealed a voltage-independent K⁢ current that was blocked...
270.

pH-mediated Regulation of Pacemaker Activity in Cultured Interstitial Cells of Cajal

ByungJooKim, JaeHwaLee, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 2 7-12 (6 pages)

ByungJooKim, JaeHwaLee, InsukSo, KiWhanKim 저
...
- 3,000원
Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation of pacemaker activity in cultured interstitial cells of Cajal. Under voltage clamp mode and at the holding potential of ⁣60 mV, the I-V relationships and difference current showed that there was no reversal potential and voltage-independent inward...

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