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271.

Effects of hydrogen peroxide on voltage-dependent K+ currents in human cardiac fibroblasts through protein kinase pathways

HyemiBae, DongheeLee, Young-WonKim, JeongyoonChoi, HongJunLee, Sang-WookKim, TaehoKim, Yun-HeeNoh, Jae-HongKo, HyoweonBang, InjaLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 11 315-324 (10 pages)

HyemiBae, DongheeLee, Young-WonKim, JeongyoonChoi, HongJunLee, Sang-WookKim, TaehoKim, Yun-HeeNoh, Jae-HongKo, HyoweonBang, InjaLim 저
...
- 3,000원
Human cardiac fibroblasts (HCFs) have various voltage-dependent K+ channels (VDKCs) that can induce apoptosis. Hydrogen peroxide (H2O2) modulates VDKCs and induces oxidative stress, which is the main contributor to cardiac injury and cardiac remodeling. We investigated whether H2O2 could modulate VDKCs in HCFs and induce cell injury through this process. In whole-cell mode patch-clamp recordings, application of H2O2 stimulated Ca2+-activated K+ (KCa) currents but not delayed rectifier K+ or...
272.

The effects of intra-articular resiniferatoxin on monosodium iodoacetate-induced osteoarthritic pain in rats

YoungkyungKim, Eun-hyeKim, KyuSangLee, KoeunLee, , SungHoPark, , SookHyunNa, CheolwoongKo6, JunesunKim, YoungWookYooon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 16 129-136 (8 pages)

YoungkyungKim, Eun-hyeKim, KyuSangLee, KoeunLee, , SungHoPark, , SookHyunNa, CheolwoongKo6, JunesunKim, YoungWookYooon 저
...
- 3,000원
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, 8 mg/50...
273.

Inducibility of human atrial fibrillation in an in silico model reflecting local acetylcholine distribution and concentration

MinkiHwang, Hyun-SeungLee, Hui-NamPak, EunBoShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 14 111-117 (7 pages)

MinkiHwang, Hyun-SeungLee, Hui-NamPak, EunBoShim 저
...
- 3,000원
Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of local acetylcholine (ACh) promotes AF. In this study, we investigated the effect of the spatial distribution and concentration of ACh on fibrillation patterns in an in silico human atrial model. A human atrial action potential model with an ACh-dependent K+ current (IKAch) was used to examine the effect of vagal...
274.

Neural circuit remodeling and structural plasticity in the cortex during chronic pain

WoojinKim, SunKwangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 1 1-8 (8 pages)

WoojinKim, SunKwangKim 저
...
- 3,000원
Damage in the periphery or spinal cord induces maladaptive plastic changes along the somatosensory nervous system from the periphery to the cortex, often leading to chronic pain. Although the role of neural circuit remodeling and structural synaptic plasticity in the ‘pain matrix’ cortices in chronic pain has been thought as a secondary epiphenomenon to altered nociceptive signaling in the spinal cord, progress in whole brain imaging studies on human patients and animal models has suggested a...
275.

Electrophysiological and Mechanical Characteristics in Human Ileal Motility: Recordings of Slow Waves Conductions and Contractions, In vitro

Seung-BumRyoo, Heung-KwonOh, SangHuiMoon, EunKyungChoe, SungAYu, Sung-HyePark, KyuJooPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 8 533-542 (10 pages)

Seung-BumRyoo, Heung-KwonOh, SangHuiMoon, EunKyungChoe, SungAYu, Sung-HyePark, KyuJooPark 저
...
- 3,000원
Little human tissue data are available for slow waves and migrating motor complexes, which are the main components of small bowel motility. We investigated the electrophysiological and mechanical characteristics of human ileal motility, in vitro. Ileum was obtained from patients undergoing bowel resection. Electrophysiological microelectrode recordings for membrane potential changes and mechanical tension recordings for contraction from smooth muscle strips and ileal segments were performed....
276.

Effects of Local Pancreatic Renin-Angiotensin System on the Microcirculation of Rat with Severe Acute Pancreatitis

ZhijianPan, LingFeng, HaochengLong, HuiWang, JiaruiFeng, FeixiangChen 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 1 299-307 (9 pages)

ZhijianPan, LingFeng, HaochengLong, HuiWang, JiaruiFeng, FeixiangChen 저
...
- 3,000원
Severe acute pancreatitis (SAP) is normally related to multiorgan dysfunction and local complications. Studies have found that local pancreatic renin-angiotensin system (RAS) was significantly upregulated in drug-induced SAP. The present study aimed to investigate the effects of angiotensin II receptors inhibitor valsartan on dual role of RAS in SAP in a rat model and to elucidate the underlying mechanisms. 3.8% sodium taurocholate (1 ml/kg) was injected to the pancreatic capsule in order for...
277.

Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum

HoaiBacNguyen, ShinYoungLee, SooHyunPark, JunHyunHan, MooYeolLee, SoonChulMyung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 10 257-262 (6 pages)

HoaiBacNguyen, ShinYoungLee, SooHyunPark, JunHyunHan, MooYeolLee, SoonChulMyung 저
...
- 3,000원
It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood. Nicotine has been reported to cause relaxation of the corpus cavernosum; it has also been reported to cause both contraction and relaxation. Therefore, high concentrations of nicotine were studied in strips from the rabbit corpus cavernosum to better understand its effects. The proximal penile...
278.

Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after Spinal Cord Injury in Rats

JunesunKim, YoungkyungKim, Suk-ChanHahm, YoungWookYoon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 7 125-130 (6 pages)

JunesunKim, YoungkyungKim, Suk-ChanHahm, YoungWookYoon 저
...
- 3,000원
Cholecystokinin is known to be involved in the modulation of nociception and to reduce the efficacy of morphine analgesia. This study investigated the effects of intrathecal administration of morphine and the cholecystokinin type B antagonist CI-988 on below-level neuropathic pain after spinal cord injury in rats. We also examined the interaction of morphine and CI-988 in the antinociceptive effect. Both morphine and CI-988 given individually increased the paw withdrawal threshold to mechanical...
279.

Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model

LiQinZhu, JianWeiYang, YuanZhang, YongMingWang, JianLeiZhang, YuanYuanZhao, WeiLinDong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 3 99-104 (6 pages)

LiQinZhu, JianWeiYang, YuanZhang, YongMingWang, JianLeiZhang, YuanYuanZhao, WeiLinDong 저
...
- 3,000원
The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intra- abdominal infected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profiles in various tissues in intra-abdominal infected human. 12 male rats with intra- abdominal infections, induced by Escherichia coli, received a single dose of 40 mg/kg body weight of moxifloxacin. Blood plasma was collected at 5, 10, 20, 30, 60, 120, 240, 480, 1440 min after drug injection. A PBPK...
280.

Airway Smooth Muscle Sensitivity to Methacholine in Precision-Cut Lung Slices (PCLS) from Ovalbumin-induced Asthmatic Mice

HaeJinKim, YeryungKim, SuJungPark, BoramBae, Hye-RyunKang, Sang-HeonCho, HaeYoungYoo, JooHyunNam, WooKyungKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 10 65-72 (8 pages)

HaeJinKim, YeryungKim, SuJungPark, BoramBae, Hye-RyunKang, Sang-HeonCho, HaeYoungYoo, JooHyunNam, WooKyungKim, SungJoonKim 저
...
- 3,000원
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR) and reversible airway obstruction. Methacholine (MCh) is widely used in broncho-provocation test to evaluate airway resistance. For experimental investigation, ovalbumin-induced sensitization is fre-quently used in rodents (Ova-asthma). However, albeit the inflammatory histology and AHR in vivo, it remains unclear whether the MCh sensitivity of airway smooth muscle isolated from Ova-asthma is persistently...

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