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Effect of Doxorubicin on Catecholamine Release in the Isolated Perfused Rat Adrenal Gland
Dong-YoonLim, Song-HoonOh, Yoo-SeungSeoh, Eun-SookLee, Il-HwanKim, Seong-HoJo, Soon-PyoHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 7 215-224 (10 pages)
rat adrenal gland. However, lower dose of DX did not affect CA secretion by high K, and higher doses of DX reduced time-dependently CA secretion of high K. It is thought that these effects of DX may be mediated by inhibiting both influx of extracellular calcium into the rat adrenomedullary chromaffin cells and intracelluar calcium release from the cytoplasmic store. Also, there was no difference in the mode of action between DX and daunorubicin in rat adrenomedullary CA secretion. -
Influence of Staurosporine on Catecholamine Release Evoked by Cholinergic Stimulation and Membrane Depolarization from the Rat Adrenal Gland
Dong-YoonLim, Yeon-SooChoi, Won-HoYang, Yong-KyoonLee, YongLim, Cheol-HeeChoi, Byung-SikYu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 10 149-158 (10 pages)
of the control release as compared to those in the presence of STS only. These results demonstrate that STS causes the marked inhibition of CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization, indicating strongly that this effect may be mediated by inhibiting influx of extracellular calcium and release in intracellular calcium in the rat adrenomedullary chromaffin cells through preventing activation of protein kinases.... -
Regulation of Magnesium Release by cAMP during Chemical Hypoxia in the Rat Heart and Isolated Ventricular Myocytes
JinShangKimAntonioScarpa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 8 59-68 (10 pages)
Chemically induced hypoxia has been shown to induce a depletion of ATP. Since intracellular free Mg2 ([Mg2]i) appears to be tightly regulated following cellular energy depletion, we hypothesized that the increase in [Mg2]i would result in Mg2 extrusion following hormonal stimulation. To determine the relation between Mg2 efflux and cellular energy state in a hypoxic rat heart and isolated myocytes, [Mg2]i, ATP and Mg2 content were measured by... -
The Inhibitory Mechanism of Aloe Glycoprotein (NY945) on the Mediator Release in the Guinea Pig Lung Mast Cell Activated with Antigen-Antibody Complexes
JaiYoulRo, ByungChulLee, MyungHeeChung, SeungKiLee, ChungKiSung, KyungHwanKim, YoungInPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 15 119-131 (13 pages)
enzyme digestion， the rough and the discontinuous density percoll gradient method. Mast cells were sensitized with IgG1 (anti-OA) and challenged with ova1bumin. Histamine was assayed by fluorometric ana1yzer， 1eukotrienes by radioimmunoassay. The phospholipase D activity was assessed by the production of 1abe1ed phosphatidy1alcoho1. The amount of mass 1， 2-diacy1g1ycero1 (DAG) was measured by the eH]DAG produced when pre1abe1ed with eH]myristic acid. The phosph01ipid methy1ation was assessed... -
Effects of Histamine H2-Receptor Stimulation on Mg2+ Efflux in Perfused Guinea Pig Heart
Hyung-SubKang, Sung-EunChang, Chang-WonKang, Soo-WanChae, Jin-SangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 6 49-54 (6 pages)
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흰쥐 대뇌피질 절편에서 허혈에 의한 Norepinephrine 유리에 있어서 Nitric Oxide의 영향 Role of Nitric Oxide in Ischemia-evoked Release of Norepinephrine from Rat Cortex Slices
김기원, 은영아, 김동찬, 조규박, Kee-WonKim, YoungAhEun, Dong-ChanKim, Kyu-ParkCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 8 673-679 (7 pages)
an electron spin trap, inhibited [3H]NE release dose-dependently. Ischemia-evoked [3H]NE release was inhibited by methylene blue, a soluble guanylate cyclase inhibitor, and potentiated by 8-bromo-cGMP, a cell permeable cGMP analog, zaprinast, a cGMP phosphodiesterase inhibitor, and S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide generator. These results suggest that the ischemia-evoked [3H]NE release is mediated by NMDA receptors, and activation of NO system is involved. -
Pharmacological Evidence that Cromakalim Inhibits Ca2+ Release from Intracellular Stores in Porcine Coronary Artery
ByungYongRhim, SunHwaHong, ChiDaeKim, WonSukLee, KiWhanHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 4 27-34 (8 pages)
K channels, 1 ㄍM) was without effect. In addition, cromakalim inhibited the GTPS (100 ㄍM, nonhydrolysable analogue of GTP)-induced increase in [Ca2]i. Based on these results, it is suggested that cromakalim and levcromakalim exert a potent vasorelaxation, in part, by acting on the K channels of the intracellular sites (e.g., sarcoplasmic reticulum membrane), thereby, resulting in decrease in release of Ca2 from the intracellular storage site. -
Hydrocortisone이 적출 흰쥐 부신에서 Histamine의 카테콜아민 분비작용에 미치는 영향
임동윤(Dong-Yoon Lim), 최형호(Hyeong-Ho Choi), 김종인(Jong-In Kim), 강정원(Jeong-Won Kang), 최철희(Cheol-Hee Choi), 오형근(Hyeong-Gueun Oh), 유호진(Ho-Jin 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1996, 제 32권 제 1호 10 83-92 (10 pages)
hydrocortisone (30uM)이나 합성 글루코콜티코이드인 dexamethasone (30uM)을 각각 20분간 전처치한 후에 현저히 증강되었다. Hydrocortisone에 의한 histamine의 CA 분비의 증강작용은 inositol trisphosphate 수용체 억제제인 heparin (3.56U/ml)으로 천처치시 뚜렷이 억제되었으나 adenylate cyclase의 강력한 활성화제인 forskolin (0.2uM)으로 전처치시 현저히 강화되었다. 이상과 같은 실험 결과를 종합한 결과, hydrocortisone (글루코콜티코이드)은 흰쥐 적출관류 부신에서 histamine의 CA 유리작용을 증강시킬 수 있으며, 이는... -
백서 대뇌피질에서 Opioid Kappa수용체의 Histamine 유리조절기능에 관한 연구
김기원(Kee-Won Kim), 조규박(Kyu-Park Cho) 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1994, 제 30권 제 1호 1 1-10 (10 pages)
증가되었다. 그러나 Bremazocine과 DIP의 Ki치는 sodium 제거 또는 GTPγS 100μM 첨가에 의해 증가되었다. 그러나 Bremazocine과 DIP의 Ki치는 sodium 제거 또는 GTPγS 첨가에 의해 영향받지 않았다. 1-[3H] histidine을 미리 부하한 대뇌피질 절편에서 30mM K+ 에 의한 [3H] histamine의 유리는 (-)EKC에 의하여 영향받지 않았다. (-)EKC의 histamine유리 억제효과는 naloxone, norbinaltorpmine 또는 bremazocine에 의하여 각각 억제되었다. 본 실험 성적은 백서 대뇌피질에서 histamine의 유리는 이 부위에 존재하는 opioid... -
흰쥐 관류부신에서 Histamine 수용체 활성화가 Catecholamine 분비작용에 미치는 영향
임동윤(Dong-Yoon Lim), 노상현(Sang-Hyun Rho) 대한약리학회 대한약리학잡지 14 Pages
대한약리학회 대한약리학잡지 1993, 제 29권 제 1호 5 43-56 (14 pages)
관찰할 수 있었다. Histamine의 CA 분비작용은 chlorisondamine, diphenhydrarmine, ranitidine, Ca++-free Krebs 용액의 관류, nicardipine 및 TMB-8 등의 전처치로 유의하게 억제 되었으나 pirenzepine의 전처치에 의해서는 별다른 영향을 받지 않았다. 더우기 histamine (6.8 × 10-5M)으로 30분간 관류시킨 후에 ACh (50μg)의 CA 분비작용이 상당히 억제됨을 나타내었다. 이상과 같은 연구 결과로 보아 histamine은 흰쥐 적출관류 부신에서 현저한 CA 분비작용을 나타내었으며 칼슘 의존성이었다. 이러한 CA 분비작용은 H1- 및 H2-...
