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Electrolysis of Physiological Salt Solution Generates a Factor that Relaxes Vascular Smooth Muscle
Pil-OhSongKi-ChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 10 217-223 (7 pages)
Oxygen-derived free radicals have been implicated in many important functions in the biological system. Electrical field stimulation (EFS) causes arterial relaxation in animal models. We found that EFS applied to neither muscle nor nerve but to Krebs solution caused a relaxation of rat aorta that had been contracted with phenylephrine. In the present study, therefore, we investigated the characteristics of this EIRF (electrolysis-induced relaxing factor) using rat isolated aorta. Results... -
Inhibitory Effects of Ginseng Saponins on c-fos mRNA Expression and the Proliferation of Rat Aortic Vascular Smooth Muscle Cells Stimulated by Angiotensin II
WoongChoi, JinYoungJung, HunSikKim, YeoPyoYun, JongDaePark, HeeYulAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 8 201-207 (7 pages)
To evaluate the possibility that the ginseng saponins could be developed as an anti-arteriosclerotic agent, we examined the inhibitory effects of ginseng saponins (total saponin[TS], panaxatriol[PT], panaxadiol[PD]) on the expression of c-fos mRNA and the proliferation of cultured rat aortic vascular smooth muscle cells (VSMCs) stimulated by angiotensin II (Ang II). TS and PT (1.0 mg/ml) suppressed c-fos mRNA induction in VSMCs stimulated by 10-5 M Ang II. The order of inhibitory potency was... -
External pH Effects on Delayed Rectifier K+ Currents of Small Dorsal Root Ganglion Neuron of Rat
YoungHoKim, JungHyunHahn, InJaLim, SungkwonChung, HyoWeonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 4 165-172 (8 pages)
Under certain pathophysiological conditions, such as inflammation and ischemia, the concentration of H+ ion in the tissue surrounding neurons is changed. Variations in H+ concentration are known to alter the conduction and/of the gating properties of several types of ion channels. Several types of K+ channels are modulated by pH. In this study, the whole cell configuration of the patch clamp technique has been applied to the recording of the responses of change of external pH on the delayed... -
기니픽의 회장평활근에서 NANC 신경전달물질의 작용기전
이영호, 김종훈, 강복순 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 20 783-796 (14 pages)
Action Mechanisms of NANC Neurotransmitters in Smooth Muscle of Guinea Pig Ileum. 2 -. T1IO .. n r 1 Young-Ho Lee'， Jong-Hoon Kim -
동방결절에서 과분극에 의해 활성화되는 내향전류에 대한 Cyclic-GMP의 영향 Effects of Cyclic-GMP on Hyperpolarization-activated inward Current (If) in Sino-atrial Node Cells of Rabbit
유신, 호원경, 엄융의, ShinYoo, Won-KyungHo, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 14 731-739 (9 pages)
The aim of present study is to investigate the effects of cGMP on hyperpolarization activated inward current (If), pacemaker current of the heart, in rabbit sino-atrial node cells using the whole-cell patch clamp technique. When sodium nitroprusside (SNP, 80μM), which is known to activate guanylyl cyclase, was added, If amplitude was increased and its activation was accelerated. However, when If was prestimulated by isopreterenol (ISO, 1μM), SNP reversed the effect of ISO. In the absence of... -
흰쥐 심근의 역 사다리 효과에 있어서 생후 연령에 따른 Na+-Ca2+ 교환의 역할에 관한 연구 Studies on the Roles of Na+-Ca2+ Exchange according to Postnatal Age in the Negative Staircase Effect of the Rat Heart
이해용, 김순진, 고창만, Hae-yongLee, SoonJinKimChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 12 707-716 (10 pages)
Recent reports revealed that the Na-Ca2 exchangers and feet structures of sarcoplasmic reticulum(SR) are located in close vicinity in the specific compartment. Therefore, we investigated the possibility that the Na-Ca2 exchanger may decrease the tension development by transporting the Ca2 out of the cell right after it released from SR, on the basis of this anatomical proximity. We exammined the negative force-frequency relationship of the developed tension in... -
Effect of pH on the ATP-sensitive K+ Channel in Aortic Smooth Muscle Cells from Rats
SeHoonKim, IlSuKim, HoeSukKim, ByeongHwaJeon, SeokJongChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 11 555-563 (9 pages)
The effects of pH on K currents were investigated in single smooth muscle cells isolated from the thoracic aorta of Wistar-Kyoto rats. Whole-cell K currents were recorded in the conventional configuration of the voltage-clamp technique. Pinacidil (10uM) activated the whole-cell current and the pinacidil-activated current was completely inhibited by glibenclamide (10uM) , an inhibitor of ATP-sensitive K channel (KATP channel). Pinacidil-activated current was reversed at near... -
The Influence of N6-cyclopentyladenosine and Magnesium on Norepinephrine Release in the Rat Hippocampus
YeungBongPark, SangDukPark, BongKyuChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 3 135-142 (8 pages)
As it has been reported that the depolarization-induced norepinephrine (NE) release is modulated by activation of presynaptic A1-adenosine heteroreceptor and various lines of evidence indicate that A2-adenosine receptor also presents in hippocampus, and that the adenosine effect is magnesium dependent, the present study was undertaken to delineate the role of adenosine receptors in the modulation of hippocampal NE release. Slices from the rat hippocampus were equilibrated with [3H]-NE and the... -
Inhibition of Phospholipase A2 Diminishes the Acute Alveolar Injury Induced by Interleukin-1
YoungManLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 9 71-78 (8 pages)
In an attempt to investigate the role of phospholipase A2(PLA2) in interleukin-1 (IL-1) induced acute lung injury, mepacrine was tried to inhibit PLA2 in IL-1 induced ARDS rats. For confirmation of acute lung injury by IL-1, and to know the role of neutrophils in this injury, lung leak index, lung myeloperoxidase(MPO), number of neutrophils and protein content in the bronchoalveolar lavage (BAL) and wet lung weight were measured. At the same time lung PLA2 was measured to know the effect of... -
Meprobamate Chlorpromazine 및 電擊療法이 白鼠의 Estrous Cycle에 미치는 影響
羅鳳鎭, 朱鐘球, 金恩洗, 金光曰 대한신경정신의학회 신경정신의학 6 Pages
대한신경정신의학회 신경정신의학 1966, 제 5권 제 1호 14 59-64 (6 pages)
