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Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring
JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 1 67-82 (16 pages)
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the... -
Mechanical Stretch-Induced Protection against Myocardial Ischemia- Reperfusion Injury Involves AMP-Activated Protein Kinase
JiaHao, Hun-SikKim, WoongChoi, TaeSunHa, Hee-YulAhn, Chan-HyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.1 1 1-9 (9 pages)
AMP-activated protein kinase (AMPK) protects various tissues and cells from ischemic insults and is activated by many stimuli including mechanical stretch. Therefore, this study investigated if the activation of AMPK is involved in stretch-induced cardioprotection (SIC). Intraventricular balloon and aorto-caval shunt (ACS) were used to stretch rat hearts ex vivo and in vivo, respectively. Stretch preconditioning reduced myocardial infarct induced by ischemia-reperfusion (I/R) and improved... -
Characterization of Hibiscus Latent Fort Pierce Virus-Derived siRNAs in Infected Hibiscus rosa-sinensis in China
Han-hong Lan, Luan-mei Lu 한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2020, 36권 6호 9 618-627 (10 pages)
Although limited progress have been made about pathogen system of Hibiscus rosa-sinensis and Hibiscus latent Fort Pierce virus (HLFPV), interaction between plant host and pathogen remain largely unknown, which led to deficiency of effective measures to control disease of hibiscus plants caused by HLFPV. In this study, infection of HLFPV in Hibiscus rosa-sinensis was firstly confirmed for the first time by traditional electron microscopy, modern reverse transcription polymerase chain reaction and... -
Computer-Aided Drug Discovery in Plant Pathology
한국식물병리학회 The Plant Pathology Journal 14 Pages
한국식물병리학회 The Plant Pathology Journal 2017, 33권 6호 1 529-542 (14 pages)
Control of plant diseases is largely dependent on use of agrochemicals. However, there are widening gaps between our knowledge on plant diseases gained from genetic/mechanistic studies and rapid translation of the knowledge into target-oriented development of effective agrochemicals. Here we propose that the time is ripe for computer-aided drug discovery/design (CADD) in molecular plant pathology. CADD has played a pivotal role in development of medically important molecules over the last three... -
Reaction of Global Collection of Rye (Secale cereale L.) to Tan Spot and Pyrenophora tritici-repentis Races in South Dakota
한국식물병리학회 The Plant Pathology Journal 9 Pages
한국식물병리학회 The Plant Pathology Journal 2017, 33권 3호 2 229-237 (9 pages)
Rye (Secale cereale L.) serves as an alternative host of Pyrenophora tritici-repentis (PTR) the cause of tan spot on wheat. Rye is cultivated as a forage or cover crop and overlaps with a significant portion of wheat acreage in the U.S. northern Great Plains; however, it is not known whether the rye crop influences the evolution of PTR races. We evaluated a global collection of 211 rye accessions against tan spot and assessed the diversity in PTR population on rye in South Dakota. All the rye... -
Insights into Tan Spot and Stem Rust Resistance and Susceptibility by Studying the Pre-Green Revolution Global Collection of Wheat
한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2017, 33권 2호 4 125-132 (8 pages)
Tan spot (TS), caused by the fungus Pyrenophora tritici-repentis (Died) Drechs, is an important foliar disease of wheat and has become a threat to world wheat production since the 1970s. In this study a globally diverse pre-1940s collection of 247 wheat genotypes was evaluated against Ptr ToxA, P. tritici-repentis race 1, and stem rust to determine if; (i) acquisition of Ptr ToxA by the P. tritici-repentis from Stagonospora nodorum led to increased pathogen virulence or (ii) incorporation of TS... -
Effects of the Occupational Therapy Using the Music-Based Cognitive Stimulation Digital Device Program on Elderly’s Cognitive Function, Depression and Hand Function
Lee Bo-Min, Sung Yoon-Jeong, Lee Jung-Hwa, Han Eun-Young, Yang Yeong-Ae 대한고령친화산업학회 대한고령친화산업학회지 11 Pages
대한고령친화산업학회 대한고령친화산업학회지 2021, 제 13권 제 1호 1 1-11 (11 pages)
Objective : The purpose of this study is to find the influence of the occupational therapy that uses a music-based cognitive stimulation digital device on normal elderly’s cognitive function, depression and hand function. Methods : From May to July 2019, the intervention was carried out twice a week for a total of 10 sessions and 60 minutes per session for five weeks. The experimental group(n=14) participated in the occupational therapy using the music-based cognitive stimulation digital device... -
The Effect on a Weight-Control Belief and Weight Index Applying to Rational Emotive Behavior Program for Overweight Adolescents
박충선 한국보건기초의학회 한국보건기초의학회지 9 Pages
한국보건기초의학회 한국보건기초의학회지 2010, Vol.3 No.1 6 40-48 (9 pages)
For the purpose of weight-loss of overweight adolescents, subjects were divided into the experimental and control group. For the two groups, 48 students, among a total of 520 second-grade students in a girls’ high school in M city. Data in this study were collected during a period of 4 months from March to June, 2008. The collected data were statistically processed by SAS Package program and analyzed with wilcoxon two-sample test and ANOVA. The results are as follows: 1) There was no... -
Payne-Aldrich Tariff Act의 일고찰-페인-올드리치 관세법 제정을 통해서 본 William Taft의 관세관을 중심으로-
동국역사문화연구소 동국사학 2018, 제 65집 4 105-140 (36 pages)
이 글은 1909년 페인-올드리치 관세법의 전개과정을 중심으로 태프트 대통령의 관세 입장을 통해 그의 정치, 경제, 사회, 제도의 인식을 살펴보았고, 당시관세 개혁을 놓고 연방의회의 상하 양원을 차지한 공화당 내부의 관세 논쟁을 살펴봄으로써 보수와 개혁간의 갈등, 조정, 분열을 검토하였다. 또한 태프트의 대통령의 리더십과 그 한계를 살펴봄으로써, 도금시대에서 혁신주의 시대로 넘어가는 과정에서 나타나는 미국사회의 제도적 명암을 살펴보았다. 이를 통해 태프트는 저가 생산품을 수출하는 외국으로부터 미국의 산업을... -
On Beyong Status Quo: Emerging e-Learning Paradigm in Education
Insook Lee 한국교육학회 한국교육학회 학술대회논문집 26 Pages
한국교육학회 한국교육학회 학술대회논문집 KSSE Inter 19 439-464 (26 pages)


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