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Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin
Min-HoPark, Seok-HoShin, Jin-JuByeon, Gwan-HoLee, Byung-YongYu, YoungG.Shin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 13 107-115 (9 pages)
Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/ human PK but also to evaluating the drug-drug interaction (DDI) liability at the drug discovery or development stage. Herein, we describe a case study to illustrate the use of PBPK approach in predicting human PK as well as DDI using in silico, in vivo and in vitro derived parameters. This case was composed of five steps such as: simulation,... -
Metabotropic glutamate receptor dependent long-term depression in the cortex
SukjaeJoshuaKang, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 1 557-564 (8 pages)
Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The hippocampus and the cerebellum have been the most extensively studied regions in mGluR-dependent LTD, and Group 1 mGluR has been reported to be mainly involved in this synaptic LTD at excitatory synapses. However, mGluR-dependent LTD in other brain regions may be involved in the... -
The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling
SungRyulLee, SuJinNoh, JuliusRyanPronto, YuJeongJeong, HyoungKyuKim, InSungSong, ZhelongXu, HyogYoungKwon, SeChanKang, Eun-HwaSohn, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 1 389-400 (12 pages)
Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn2+) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc’s critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and... -
Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains
Keun-SungLee, Jin-KooLee, Hyung-GunKim, HakRimKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 13 89-97 (9 pages)
Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before human application. However, which of the plethora of experimental animal species to use in model development can be perplexing. Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a very well known method to induce the symptoms of Parkinson's disease in mice. But, there is very limited... -
Modulation of L-type Ca2+ Channel Currents by Various Protein Kinase Activators and Inhibitors in Rat Clonal Pituitary GH3 Cell Line
YoungMinBae, Hye-JungBaek, HanaCho, YungEEarm, Won-KyungHo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 4 139-146 (8 pages)
(PTP) inhibitor, increased the Ba2 current through the L-type Ca2 channels. In contrast, bisindolylmaleimide I (BIM I), a PKC inhibitor, and genistein, a protein tyrosine kinase (PTK) inhibitor, suppressed the Ba2 currents. Forskolin, an adenylate cyclase activator, and isobutyl methylxanthine (IBMX), a non-specific phosphodiesterase inhibitor, reduced Ba2 currents. The above results show that the L-type Ca2 channels are activated by PKC and PTK, and inhibited... -
Opening of ATP-sensitive K+ Channel by Pinacidil Requires Serine/ Threonine Phosphorylation in Rat Ventricular Myocytes
Yong-GeunKwakSoo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 7 293-303 (11 pages)
1B (PTP1B, 10 μg ml1), but blocked by the pretreatment of protein phosphatase 2A (PP2A, 1 U ml1). In addition, pinacidil (10 μM) could not induce the opening of the reactivated KATP channels in the presence of H-7 (100 μM) but enhanced it in the presence of ATP (1 mM) and genistein (30 μM). These results indicate that the KATP channel-opening effect of pinacidil is not mediated via phosphorylation of KATP channel protein or associated protein, although it still requires the... -
Exploring Sources of Life Meaning among Koreans
Mira Kim, Hong Seock Lee, Sang Kyu Lee 대한신경정신의학회 신경정신의학 18 Pages
대한신경정신의학회 신경정신의학 2002, 제 41권 제 5호 17 912-929 (18 pages)
연구목적： 본 연구에서는 한국인들의 독특한 문화와 가치관을 반영하는 삶의 의미의 기본적 구조를 밝히고자 하 였다. 방 법： 정성적 조사방법과 정량적 조사방법의 두가지 조사방법이 이용되었고, 이에 따라 각 연구를 위한 두 차례의 설문조사를 실시하였다. 정성적 조사방법을 이용한 첫번째 연구는 탐험적 연구(exploratory study)로 한국인들의 삶의 의미의 가능한 모든 원천을 알아내기 위해 content analysis를 실시하였다. 반면, 정량적 조사방법을 이용한 두 번째 연구에서는 한국인의 삶의 의미의 구조를 결정하기 위한 것으... -
산성 인지질 이중층의 열적 상전이에 미치는 칼슘과 페노치아진 유도체의 영향
김남홍(Nam-Hong Kim), 노승배(Sung-Bae Roh) 대한약리학회 대한약리학잡지 6 Pages
대한약리학회 대한약리학잡지 1990, 제 26권 제 1호 9 77-82 (6 pages)
Dipalmitoyl phosphatidylcholine(DPPC)과 dipalmitoyl phosphatidic acid(DPPA) 리포좀내 이중층의 열적 상전이에 미치는 칼슘과 페노치아진 유도체의 영향을 시차 열량 분석계로 연구하였다. 인지질 이중층은 가열시 어느 특정온도에서 급격한 구조적 변화를 가져왔다. 이러한 온도에 의존한 변화는 순수 인지질의 경우 특이할 만큼 예민하였다. 순수 인지질에 페노치아진 유도체를 가하였을 때 순수 인지질의 상전이 온도보다 낮은 온도에서 일어 났으며 상전이 열그림을 넓적하게 만들었다. 칼슘 이온은 DPPC: DPPA(34: 66mol%)의... -
Modulatory Effect of the Tyrosine Kinase and Tyrosine Phosphatase on the ACh-activated K+ Channel in Adult Rat Atrial Cells
Chang, Kyeong-Jae, Rhie, Sang-Ho, Heo, Ilo, Kim, Yang-Mi, Haan, Jae-Hee, Hong, Seong-Geun 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 2호 3 209-218 (10 pages)
(PTP) in the function of the KACh Channel. In the inside-out (I/O) patch preparation excised from the adult rat atrial cell, when activated by 10 μM ACh in the pipette and 100 μM GTP in the bath, the mean open time (τo) and the channel activity (KACh) was 1.13 ms (n=5) and 0.19 (n=6), respectively. Following the application of 1 mM ATP into the bath, τo increased by 34% (1.54 ms, n=5) and KACh by 66% (0.28, n=6). Channel function elevated by ATP was lasted after washout of ATP. However, this... -
창의성기반 교원교육체제 구축: 분산적 창의성과 창의적 교수
박선형 한국교원교육학회 한국교원교육학회 학술대회자료집 30 Pages
한국교원교육학회 한국교원교육학회 학술대회자료집 공동학술대회 자료집 2 31-60 (30 pages)
