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Identification of a Marker Protein for Cardiac Ischemia and Reperfusion Injury by Two-Dimensional Gel Electrophoresis and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry
YoungsukLee, NariKim, HyunjuKim, HyunJoo, YoungnamKim, DaehoonJeong, DangVanCuong, EuiyongKim, DaeYoungHur, YoungShikPark, YongGeunHong, Sa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.4 6 207-212 (6 pages)
The purpose of the present study was to evaluate the expression of cardiac marker protein in rabbit cardiac tissue that was exposed to ischemic preconditioning (IPC), or ischemiareperfusion injury (IR) using two-dimensional gel electrophoresis (2DE) and matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). We compared 2DE gels of control (uninjured) cardiac tissue with those of IPC and IR cardiac tissue. Expression of one protein was detected in IR heart tissue, however the... -
Changes in Excitability of Neurons in Rat Medial Vestibular Nucleus Following Vestibular Neurectomy
SangWooChun, JeongHeeChoi, ShinHyungLee, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 2 287-291 (5 pages)
Intrinsic excitabilities of acutely isolated medial vestibular nucleus (MVN) neurons of rats with normal labyrinth and with undergoing vestibular compensation from 30 min to 24 h after unilateral vestibular deafferentation (UVD) were compared. In control rats, proportions of type A and B cells were 30 and 70%, respectively, however, the proportion of type A cells increased following UVD. Bursting discharge and irregular firing patterns were recorded from 2 to 12 h post UVD. The spontaneous... -
Zn2+ Modulates the Responses of Rat Dorsal Horn Neuron to C-Fiber Stimulation and Excitatory Amino Acids
ChangHoonAhn, HongKeeShin, JinHyukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 3 445-453 (9 pages)
Zinc contained in the neurons of central nervous system is activity-dependently released and then attenuates NMDA (N-methyl-D-aspartate)-induced neurotoxicity while augmenting non-NMDA-induced neurodegeneration. Zinc also has been reported to produce antinociceptive action on the inflammation- and nerve injury-induced hyperalgesia in the behavioral test. In this study, we investigated the effects of zinc on the responses of dorsal horn cells to NMDA, kainate and graded electrical stimulation of... -
Natriuresis Induced by Intracerebroventricular Diazepam in Rabbits
Jeong-TaeKohYoung-JohngKook 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 3 555-563 (9 pages)
The renal function is under regulatory influence of central nervous system (CNS), in which various neurotransmitter and neuromodulator systems take part. However, a possible role of central GABA- benzodiazepine system on the central regulation of renal function has not been explored. This study was undertaken to delineate the renal effects of diazepam. Diazepam, a benzodiazepine agonist, administered into a lateral ventricle (icv) of the rabbit brain in doses ranging from 10 to 100... -
The K+ Channels of Colonic Crypts and Their Regulation
R.Greger, K.Hamm, R.Warth, M.Nielsen, B.Wey, D.Ecke, N.Riedemann, U.Gerlach, A.E.Busch, H.C.Englert, M.Hropot, H.J.Lang, M.Bleich 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 1 403-409 (7 pages)
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Differential Effect of Homocysteic Acid and Cysteic Acid on Changes of Inositol Phosphates and [Ca2+]i in Rat Cerebellar Granule Cells
Won-KiKimYoung-SookPae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 5 41-48 (8 pages)
of physiological sa1t solution maintained at 370C, and aerated with 95% 02/5% CO2. Isometric myography was -
Changes of Renal Peripheral Benzodiazepine Receptor in the Stress/ Anxiety Response
Jeoung-HeeHa, Kwang-HunLee, Seung-DoukCheung, Hyung-BaePark, Maan-GeeLee, Hyoung-ChulChoi, Uy-DongSohn, Kwang-YounLee, Won-JoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 7 523-528 (6 pages)
Peripheral benzodiazepine receptor(PBR) has been indentified in various peripheral tissues including kidney. The physiological and pharmacological functions of PBR are still uncertain, althought it has been suggested that these are associated with the regulation of stress/anxiety response. Diazepam progeny, which were exposed to diazepam perinatally, was reported to be an animal model of chronic anxiety. However, PBR in the diazepam progenies are not known yet. In the present study, therefore,... -
Two Types of Voltage-dependent Outward Potassium Currents in Smooth Muscle Cells of Rabbit Basilar Atery
TongMookKang, InsukSo, DaeYongUhm, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 15 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 7 169-183 (15 pages)
We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current (IK(V)) and 'A-like' transient outward K current (Ito) with patch-clamp technique in single smooth muscle cells (SMCs) isolated from rabbit basilar artery, and investigated the characteristics of them. The time-courses of activation were well fitted by exponential function raised to second power (n2) in IK(v) and fourth power (n4) in Ito. The activation, inactivation and... -
Diazepam이 강박 스트레스 흰쥐 뇌의 Fos 발현에 미치는 영향
조성일, 이성필, 이창욱, 김우선, 백인호 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 5호 15 927-934 (8 pages)
흰쥐 대뇌 변연계의 몇몇 부위에서 강박 스트레스로 인한 Fos 발현 정도와 diazepam의 효과를 평가하여 스트레스에 의한 뇌의 Fos 발현이 diazepam의 영향을 받는지를 알아봄으로써 diazepam의 항불안효과와 관련된 뇌 부위를 규명하고자 본 실험을 시도하였다. 흰쥐 뇌에서 강박 스트레스와 diazepam에 의한 Fos 발현의 차이를 Fos 항체를 이용한 면역조직화학법으 로 관찰하였다. 실험 동물로는 체중 200∼250g의 Sprague-Dawley 수컷 흰쥐 20마리를 사용하였으며 4 개군으로 나누어 각군마다 5마리씩을 배당하였다. 실험군은... -
백서의 우울모형에서의 칼슘통로 길항제 에타베린(Ethaverine)의 항우울효과
이상경, 김선희, 김록우, 윤성환, 김용관, 김경태, 김영훈 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 2호 17 445-455 (11 pages)
연구목적: 본 전임상연구에서는 우울증의 두가지 동물모형을 통해 에타베린이 단독 혹은 이미프라민과 병용처치 되 었을 때의 효과를 알아보고자 하였다. 방 법: 표준화된 검사법인 강제수영검사를 사용하여 웅성백서에게 에타베린(20mg/kg) 및 이미프라민(20mg/ kg)을 단독 혹은 병용 처치하였을 때의 부동시간의 변화를 관찰하였고, 경도의 만성 스트레스를 3주 간 가한 후 4주간 에타베린과 이미프라민을 단독 혹은 병용 처치하였을때의 자당섭취량의 변화를 관찰하 였다. 결 과: 약물을 1회 단기처치 및 7일간 장기처치한...


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