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331.

TASK-1 Channel Promotes Hydrogen Peroxide Induced Apoptosis

JihyunYun, SeungtaeKim, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 9 63-67 (5 pages)

JihyunYun, SeungtaeKim, HyoweonBang 저
...
- 1,500원
in HEK-293 cells, and cytotoxicity assay was preformed using cell counting kit-8 (CCK-8). Cell survival rates were calculated using the cytotoxicity assay data and dose-response curve was fitted to the H2O2 concentration. Ionic currents were recorded in cell-attached mode. The bath solution was the normal Ringer solution and the pipette solution was high K⁢ solution. In HEK-293 cells expressing TREK-1, TREK-2, TASK-3, H2O2 induced cell death did not change in comparison to non-transfected...
332.

Effects of PCB Congeners in Rodent Neuronal Cells in Culture

Sun-YoungKimJae-HoYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 2 9-16 (8 pages)

Sun-YoungKimJae-HoYang 저
...
- 3,000원
high dose showed a significant increase of total protein kinase C (PKC) activity at phobol 12,13-dibutyrate ([3H]PDBu) binding assay, indicating that non-coplanar PCBs are more neuroactive than coplanar PCBs in neuronal cells. PKC isozymes were immunoblotted with the selected monoclonal antibodies. PKC-α, δ, and ε were activated with non-coplanar PCB exposure. Receptor for activated C kinase-1 (RACK-1), anchoring protein for activated PKC, was more induced with exposure to coplanar PCBs than...
333.

Cytotoxicological Effect of Tebufenozide, an Insect Growth Regulator (IGR): Stimulation of Filamentous Actin Reorganization and Enhancement of Hsp27 Expression in Drosophila Kc Cells

JeeNaHwang, Hwa-JinJung, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 10 351-354 (4 pages)

JeeNaHwang, Hwa-JinJung, YoungRokSeo 저
...
- 1,500원
The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and striking morphological changes including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells...
334.

Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 9 345-350 (6 pages)

HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 저
...
- 3,000원
Here, we present a suggestion that a protein(s) is the major target for heat shock apoptosis. We firstly found glycerol, which reportedly stabilizes protein structure, showed a protective effect in Raji cells against hyperthermic apoptosis. In addition, quercetin, which modulates transcription of the heat shock protein family members, enhanced apoptotic death induced by hyperthermia. Furthermore, Raji cells are protected by a pre-mild heat treatment prior to the killing dose of heat shock.
335.

The Improvement of Learning and Memory Ability of Normal Persons by BF-7

SangHyungLee, YongSikKim, YongKooKang, OhSangKwon, YongKyooShin, JinHoSong, MooYeolLee, Kwang-GillLee, Joo-HongYeo, WonBokLee, TaeJinLee, S 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 3 307-312 (6 pages)

SangHyungLee, YongSikKim, YongKooKang, OhSangKwon, YongKyooShin, JinHoSong, MooYeolLee, Kwang-GillLee, Joo-HongYeo, WonBokLee, TaeJinLee, S 저
...
- 3,000원
dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving...
336.

Helicobacter pylori Vacuolating Toxin Exhibits Polar Activity of Cl- Secretion and Secretory Response to Carbachol in T84 Cells

NanGeJin, YongRiJin, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 8 289-293 (5 pages)

NanGeJin, YongRiJin, InsukSo, KiWhanKim 저
...
- 1,500원
low pH-pretreated VacA increased short circuit current (Isc). The effect was time- and dose-dependent and saturable. The time-to-peak Isc was concentration-dependent. Chloride channel inhibitors, niflumic acid or 5- nitro-2-(3-phenylpropylamino)-benzoate (NPPB), inhibited VacA-stimulated Isc. Carbachol (CCh)-induced increase of Isc was prolonged by the addition of VacA to the mucosal side only. The effect was unaltered by the addition of niflumic acid. VacA did not show cytopathic effects. These...
337.

The Role of BF-7 on Neuroprotection and Enhancement of Cognitive Function

Hee-SunChae, YongKooKang, YongKyuShin, HyunJungLee, Ji-InYu, KwangGillLee, JooHongYeo, YongSikKim, Dong-SuepSohn, KyungYongKim, WonBokLee, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.4 1 173-180 (8 pages)

Hee-SunChae, YongKooKang, YongKyuShin, HyunJungLee, Ji-InYu, KwangGillLee, JooHongYeo, YongSikKim, Dong-SuepSohn, KyungYongKim, WonBokLee, 저
...
- 3,000원
Amyloid β-peptide (Aβ) contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against Aβ -induced toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student....
338.

Anti-Apoptotic Effect of Rheum undulatum Water Extract in Pancreatic β-cell Line,

SeoHyunYoon, MeeSookHong, JooHoChung, SungHyunChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 8 51-55 (5 pages)

SeoHyunYoon, MeeSookHong, JooHoChung, SungHyunChung 저
...
- 1,500원
Sopungsungi-won has been used as a traditional medicine for diabetes and it has been proved to be a potential remedy for type 2 diabetes mellitus. We previously reported that water extract of Sopungsungi-won exhibits anti-diabetic effects both in vivo and in vitro experiments. In the present study, we have chosen to examined anti-apoptotic effect of Rheum undulatum, which is the main component of Sopungsungi-won, on pancreatic β-cells, HIT-T15, against hydrogen peroxide (H2O2). oxidative...
339.

Cooperation of Gβ and Gαq Protein in Contractile Response of Cat Lower Esophageal Sphincter (LES)

UyDongSohnTaiSangLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 9 349-355 (7 pages)

UyDongSohnTaiSangLee 저
...
- 3,000원
dose dependent manner in LES and esophageal muscle cells obtained by enzymatic digestion with collagenase. PLC-β1 or PLC-β3 antibody incubation reduced contraction in response to ACh in LES but not in esophageal permeabilized cells, but PLC-γ1 antibody incubation did not have an inhibitory effect. The inhibition by PLC-β1 or PLC-β3 antibody on Ach-induced contraction was antibody concentration dependent. The combination with PLC-β1 and PLC-β3 antibody completely abolished the contraction,...
340.

Involvement of Oxidative Stress and Poly(ADP-ribose) Polymerase Activation in 3-Nitropropionic Acid-induced Cytotoxicity in Human Neuroblastoma Cells

EunjooNam, YoungJaeLee, YoungAhOh, JinAhJung, HyeInIm, SeongEunKoh, SunghoMaeng, WanSeokJoo, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 6 325-331 (7 pages)

EunjooNam, YoungJaeLee, YoungAhOh, JinAhJung, HyeInIm, SeongEunKoh, SunghoMaeng, WanSeokJoo, YongSikKim 저
...
- 3,000원
involved in the process, such as metabolic inhibition, generation of reactive oxygen species (ROS), DNA strand breakage, and activation of Poly(ADP-ribose) polymerase (PARP). Exposure of SK-N-BE(2)C neuroblastoma cells to 3-NP for 48 h caused actual cell death, while inhibition of mitochondrial function was readily observed when exposed for 24 h to low concentrations (0.2∼2 mM) of 3-NP. The earliest biochemical change detected with low concentration of 3-NP was an accumulation of ROS (4 h after...

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