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총 385건 검색
본문검색 결과만 보기
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Effects of Tributyltin Chloride on the Reproductive System in Pubertal Male Rats
Wook-joon Yu, Sang-yoon Nam, Young-chul Kim, Beom-jun Lee, Young-won Yun 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2003, 제 4권 제 1호 5 29-34 (6 pages)
Detrimental effects of tributyltin (TBT) chloride on the reproductive system were investigated in pubertal male rats. Sixty Sprague-Dawley rats aged with 35 days were assigned to six different groups; negative control receiving vehicle, positive control receiving methyltestosterone (10 mg/kg B.W.), TBT chloride (5 mg/kg B.W., 10 mg/kg B.W., and 20 mg/kg B.W.), and a combination of TBT chloride (10 mg/kg B.W.) and flutamide (10 mg/kg B.W). The animals were treated with test compounds by oral... -
Effect of fever on pharmacokinetics and dosage regimen of intramuscularly administered amikacin in goats
A. K. Agrawal, S. D. Singh, C. Jayachandran 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2001, 제 2권 제 2호 4 91-96 (6 pages)
A comparative pharmacokinetic study of amikacin (10 mg/kg intramuscular) by microbiological assay method in normal and experimentally induced febrile goats revealed that the plasma drug concentrations were significantly higher in febrile condition at most of the time intervals. Various pharmacokinetic parameters like t(1/2), AUC, AUMC, MRT and Vd(area) were significantly higher whereas total body clearance (Cl(B)) was significantly lower in febrile goats as compared to normal goats. Absorption... -
청소년의 음악문화활동, 교우 및 교사관계, 자아효능감이 음악교과 흥미와 성취에 미치는 효과
한수정(Su Jeong Han), 한경훈(Kyung Hoon Han) 한국음악교육학회 음악교육연구 28 Pages
한국음악교육학회 음악교육연구 2014, 제 43권 제 4호 10 211-238 (28 pages)
본 연구는 청소년의 음악문화활동, 교우관계, 교사관계, 자아효능감이 음악교과의 흥미 및 성취에 미치는 인과관계의 효과를 탐색한 것이다. 연구의 대상은 한국교육고용패널(KEEP) 1차 조사 자료의 중학교 3학년 1,995명이며, 수집된 자료는 각 변인들 간의 관계를 파악하기 위해 상관분석, 구조방정식모형 분석을 활용하였다. 분석결과, 학생의 음악문화활동은 교우관계, 교사관계에 유의한 영향을 미치며, 교우관계, 교사관계, 자아효능감은 음악교과 흥미 및 성취에 영향을 미치는 중요한 매개요인임이 확인되었다. 이러한 결과는... -
Developmental changes in GABAA tonic inhibition are compromised by multiple mechanisms in preadolescent dentate gyrus granule cells
SudipPit, GyuSeungLee, JinBongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 15 695-702 (8 pages)
The sustained tonic currents (Itonic) generated by γ-aminobutyric acid A receptors (GABAARs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating Itonic in the hippocampus are known, their combined role in Itonic regulation is not well understood in different age groups. In this study, we demonstrated that a developmental increase in GABA transporter (GAT) expression, combined with gradual decrease in GABAAR α5 subunit, resulted in various Itonic in the... -
Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice
MinhCongNguyen, SungwooRyoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 10 83-90 (8 pages)
Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the activity of endothelial nitric oxide synthase (eNOS) and limits NO generation. Hence, arginase inhibition is suggested to be vasoprotective in aging. In this study, we examined the effects of intravenous injection of Piceatannol, an arginase inhibitor, on aged mice. Our results show that Piceatannol... -
Anti-inflammatory Effects of Flavonoids on TNBS-induced Colitis of Rats
MinjaeJoo, HanSangKim, TaeHoonKwon, AlishaPalikhe, TinSarZaw, JiHoonJeong, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 7 43-50 (8 pages)
It has been shown that the extracts including eupatilin and quercetin-3-β-D-glucuronopyranoside had mucoprotective effects on the esophagus and stomach through their antioxidant activities. This study was designed to investigate the anti-inflammatory effect of these flavonoid compounds in an animal model of inflammatory bowel disease induced by 2,4,6-trinitrobenzene sulfonic acid. Experimental colitis was induced by intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid. Extracts... -
Yoga Training Improves Metabolic Parameters in Obese Boys
DaeYunSeo, SungRyulLee, ArturoFigueroa, HyoungKyuKim, YeongHoBaek, YiSubKwak, NariKim, TaeHoonChoi, ByoungDooRhee, KyungSooKo, ByungJooPar 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 4 175-180 (6 pages)
Yoga has been known to have stimulatory or inhibitory effects on the metabolic parameters and to be uncomplicated therapy for obesity. The purpose of the present study was to test the effect of an 8-week of yoga-asana training on body composition, lipid profile, and insulin resistance (IR) in obese adolescent boys. Twenty volunteers with body mass index (BMI) greater than the 95th percentile were randomly assigned to yoga (age 14.7±0.5 years, n=10) and control groups (age 14.6±1.0 years,... -
Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells
Sun-YoungLee, Kyoung-WonKo, Won-KyungKang, Yun-JeongChoe, Yoon-HyoungKim, In-KyungKim, JinKim, Ho-ShikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 9 407-412 (6 pages)
3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced intrinsic apoptotic pathway. DZA activated typical caspase-dependent apoptosis in HL-60 cells, as demonstrated by an accumulation of hypo-diploidic cells, the processing of multiple procaspases and an inhibitory effect of z-VAD-Fmk on this cell death. During... -
Regional Differences in Mitochondrial Anti-oxidant State during Ischemic Preconditioning in Rat Heart
VuThiThu, DangVanCuong, NariKim, JaeBoumYoum, MohamadWarda, WonSunPark, JaeHongKo, EuiyongKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 3 57-64 (8 pages)
Ischemic preconditioning (IPC) is known to protect the heart against ischemia/reperfusion (IR)-induced injuries, and regional differences in the mitochondrial antioxidant state during IR or IPC may promote the death or survival of viable and infarcted cardiac tissues under oxidative stress. To date, however, the interplay between the mitochondrial antioxidant enzyme system and the level of reactive oxygen species (ROS) in the body has not yet been resolved. In the present study, we examined the...
