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361.

Comparison of the Determinants in the Differences in Force- Frequency Relationships between Rat and Rabbit Left Atria

ChangMannKoSoon-JinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 11 417-425 (9 pages)

ChangMannKoSoon-JinKim 저
...
- 3,000원
The underlying mechanism commonly applicable for both the positive and negative force-frequency relationships (FFR) was pursued in left atria (LA) of rat and rabbit. The species differences in the roles of Na⁢/Ca2⁢ exchanger and sarcoplasmic reticulum (SR), which are major intracellular Ca2⁢ regulatory mechanisms in the heart, were examined in the amplitude accommodation to the frequency that changed from 3 Hz to the variable test frequencies for 5 minutes in the electrically...
362.

Neurotensin Enhances Gastric Motility in Antral Circular Muscle Strip of Guinea-pig

TaeYongKoh, SungJoonKim, SangJinLee, TongMookKang, JaeYeoulJun, JaeHoonSim, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 7 227-234 (8 pages)

TaeYongKoh, SungJoonKim, SangJinLee, TongMookKang, JaeYeoulJun, JaeHoonSim, InsukSo, KiWhanKim 저
...
- 3,000원
Many reports suggest that neurotensin (NT) in the gastrointestinal tract may play a possible role as a neurotransmitter, a circulating hormone, or a modulator of motor activity. NT exerts various actions in the intestine; it produces contractile and relaxant responses in intestinal smooth muscle. This study was designed to investigate the effect of NT on motility of antral circular muscle strips in guinea-pig stomach. To assess the role of Ca2⁢ influx in underlying mechanism, slow waves...
363.

Relatoinship between Sarcoplasmic Reticular Calcium Release and Na+-Ca2+ Exchange in the Rat Myocardial Contraction

Eun-GiKim, SoonJinKim, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 4 197-210 (14 pages)

Eun-GiKim, SoonJinKim, ChangMannKo 저
...
- 4,300원
14 mM EGTA. Finally, the Na⁢ current-dependent fraction of the inward current was increased in a stimulation frequency-dependent manner. From these results, it is concluded that the Ca2⁢ exit-mode (forward-mode) Na⁢-Ca2⁢ exchange suppresses the LA tension by extruding Ca2⁢ out of the cell right after its release from sarcoplasmic reticulum (SR) in a frequency-dependent manner during contraction, resulting in the negative frequency-force relationship in the rat LA.
364.

Changes in the Endothelin-1-induced Contraction of Aorta in Streptozotocin-induced Diabetic Rats

HyunJooCheong, EunJinKim, SuJinKim, SunHeeLee, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 3 185-195 (11 pages)

HyunJooCheong, EunJinKim, SuJinKim, SunHeeLee, ByungYongRhim 저
...
- 4,000원
Vascular diseases are significant complications of diabetes mellitus (DM), and the endothelial cells may play a pivotal role in the development of vascular disease in DM. Endothelin-1 (ET-1) released from endothelium is a potent vasoconstrictor peptide and circulating level of ET-1 is increased in a variety of disease states. The purpose of this study was to determine the changes of responsiveness to ET-1 in DM, and we experimented on the changes in the ET-1-induced contraction, levels of...
365.

Influence of Staurosporine on Catecholamine Release Evoked by Cholinergic Stimulation and Membrane Depolarization from the Rat Adrenal Gland

Dong-YoonLim, Yeon-SooChoi, Won-HoYang, Yong-KyoonLee, YongLim, Cheol-HeeChoi, Byung-SikYu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 10 149-158 (10 pages)

Dong-YoonLim, Yeon-SooChoi, Won-HoYang, Yong-KyoonLee, YongLim, Cheol-HeeChoi, Byung-SikYu 저
...
- 3,000원
of the control release as compared to those in the presence of STS only. These results demonstrate that STS causes the marked inhibition of CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization, indicating strongly that this effect may be mediated by inhibiting influx of extracellular calcium and release in intracellular calcium in the rat adrenomedullary chromaffin cells through preventing activation of protein kinases....
366.

The Effect of NO Donor on Contraction, Cytosolic Ca2+ Level and Ionic Currents in Guinea-pig Ileal Smooth Muscle

Seong-ChunKwon, Ki-YoungPark, Duck-SunAhn, Young-HoLee, Bok-SoonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 5 33-40 (8 pages)

Seong-ChunKwon, Ki-YoungPark, Duck-SunAhn, Young-HoLee, Bok-SoonKang 저
...
- 3,000원
This study was designed to clarify the mechanism of the inhibitory action of a nitric oxide (NO) donor, 3-morpholino-sydnonimine (SIN-1), on contraction, cytosolic Ca2⁢ level ([Ca2⁢]i), and ionic currents in guinea-pig ileum. SIN-1 (0.01∼100μM) inhibited 25 mM KCl- or histamine (10μM)-induced contraction in a concentration-dependent manner. SIN-1 reduced both the 25 mM KCl- and the histamine-stimulated increases in muscle tension in parallel with decreased [Ca2⁢]i. Using...
367.

Enhancement of Cyclosporine-Induced Oxidative Damage of Kidney Mitochondria by Iron

Yoon-YoungJang, Eun-SookHan, Chung-SooLee, Young-KiKim, Jin-HoSong, Yong-KyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 12 631-640 (10 pages)

Yoon-YoungJang, Eun-SookHan, Chung-SooLee, Young-KiKim, Jin-HoSong, Yong-KyooShin 저
...
- 3,000원
The present study investigated the stimulatory effects of iron (or ascorbate) on cyclosporine-induced kidney mitochondrial damage. Damaging effect of 50 μM cyclosporine plus 20 μM Fe2⁢ on mitochondrial lipids and proteins of rat kidney and hyaluronic acid was greater than the summation of oxidizing action of each compound alone, except sulfhydryl oxidation. Cyclosporine and 100 μM ascorbate showed an enhanced damaging effect on lipids but not on proteins. The peroxidative action of...
368.

Hemorrhage- and Restraint-induced Analgesia in Male and Female Conscious Rats

SungYunOh, HeeSeokHan, DongKukAhn, JaeSikPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.6 3 555-563 (9 pages)

SungYunOh, HeeSeokHan, DongKukAhn, JaeSikPark 저
...
- 3,000원
It is well known that stress induces analgesia. This study was designed to demonstrate the stress-induced analgesia by employing hemorrhage and restraint and to investigate its mechanism and sex difference. The degree of pain was assessed by measuring the magnitude of jaw opening reflex produced by a noxious electrical stimulation in the dental pulp and by measuring the latency to withdraw the tail from a heat ray. Restraint showed an antinociceptive response. A significant increase in pain...
369.

Enhanced Expression of Inducible Nitric Oxide Synthase May Be Responsible for Altered Vascular Reactivity in Streptozotocin-induced Diabetic Rats

JaeKwonJang, YoungJinKang, HanGeukSeo, SookJaeSeo, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 2 375-382 (8 pages)

JaeKwonJang, YoungJinKang, HanGeukSeo, SookJaeSeo, KiChurlChang 저
...
- 3,000원
nitrotyrosine, a specific foot print of peroxynitrite, was significantly increased in endothelial cells and smooth muscle layers in STZ-induced diabetic aorta. Taken together, the present findings indicate that enhanced release of NO by iNOS along with increased lipid peroxidation in diabetic conditions may be responsible, at least in part, for the augmented contractility, possibly through the modification of endothelial integrity or ecNOS activity of endothelium in STZ-diabetic rat aorta.
370.

Tissue-Specific Regulation of Angiotensinogen and Angiotensin II Receptor Gene Expression in Deoxycorticosterone Acetate-Salt Hypertensive Rats

JongUnLeeMiRaAn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 9 315-320 (6 pages)

JongUnLeeMiRaAn 저
...
- 3,000원
Molecular regulation of the renin-angiotensin system (RAS) was investigated in deoxycorticosterone acetate (DOCA)-salt hypertension. The expression of renin, angiotensinogen and angiotensin II receptor genes in the kidney and liver was determined by Northern blot analysis in rats which were made DOCA-salt hypertensive over the period of 2 or 4 weeks. Along with the hypertension, renin mRNA was decreased in the remnant kidney. The expression of angiotensinogen gene was not significantly altered...

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