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381.

Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Interleukin-6 Release and Expression in Primary Neonatal Cardiomyocytes

Han-JungChae, Hyun-KiKim, Wan-KuLee, Soo-WanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 7 319-325 (7 pages)

Han-JungChae, Hyun-KiKim, Wan-KuLee, Soo-WanChae 저
...
- 3,000원
The induction of interleukin-6 (IL-6) using combined proinflammatory agents (LPS/IFN-γ or TNF-α/ IFN-γ) was studied in relation to p38 mitogen-activated protein kinase (MAPK) and NF-κB transcriptional factor in primary neonatal cardiomyocytes. When added to cultures of cardiomyocytes, the combined agents (LPS/IFN-γ or TNF-α/IFN-γ) had stimulatory effect on the production of IL-6 and the elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB203580 inhibited...
382.

Effects of Interleukin-1β and Tumor Necrosis Factor-α on the Release of Collagenase and Gelatinase from Osteoblasts

Jong-GabEun, Dong-HeonBaek, Se-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 6 269-274 (6 pages)

Jong-GabEun, Dong-HeonBaek, Se-WonKim 저
...
- 3,000원
by gel substrate analysis (zymography) after electrophoresis of conditioned media of osteoblastic cell culture. IL-1β increased the collagenase activity in ROS17/2.8 and HOS cell culture. TNF-α also increased the collagenase activity of osteoblastic cells. When two kinds of cytokines were treated simultaneously in the culture of osteoblastic cells, synergistic increase of collagenase activity was seen in ROS17/2.8 cells. IL-1β and TNF-α significantly increased the collagenase activity after...
383.

Noradrenergic Modulation of Spontaneous Inhibitory Postsynaptic Currents in the Hypothalamic Paraventricular Nucleus

LongHwaLee, WoneeChong, KihoLee, JinBongPark, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 2 71-80 (10 pages)

LongHwaLee, WoneeChong, KihoLee, JinBongPark, PanDongRyu 저
...
- 3,000원
Previous studies have suggested that brain stem noradrenergic inputs differentially modulate neurons in the paraventricular nucleus (PVN). Here, we compared the effects of norepinephrine (NE) on spontaneous GABAergic inhibitory postsynaptic currents (sIPSCs) in identified PVN neurons using slice patch technique. In 17 of 18 type I neurons, NE (30∼100μM) reversibly decreased sIPSC frequency to 41⁑7% of the baseline value (4.4⁑0.8 Hz, p＜0.001). This effect was blocked by yohimbine...
384.

Congenital LQT Syndromes From Gene to Torsade de Pointes

EdwardCarmeliet 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.1 1 1-8 (8 pages)

EdwardCarmeliet 저
...
- 3,000원
Congenital Long QT syndrome (LQTs) is a relatively rare pathologic disorder but results frequently in sudden cardiac death. Of the six LQTs that have been clinically described, five have been worked out for their genetic and biophysical profile. Most are generated by mutations which cause a loss of function in two delayed K⁢currents, iKs and iKr. One syndrome is generated by mutations in the Na⁢ channel which causes essentially a gain of function in the channel. Clinically the...
385.

Molecular Aspects of Organic Ion Transporters in the Kidney

SeokHoChaHitoshiEndou 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 1 107-122 (16 pages)

SeokHoChaHitoshiEndou 저
...
- 4,500원
A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the body from harmful substances. The renal proximal tubule is the primary site of carrier-mediated transport from blood into urine. During the last decade, molecular cloning has identified several families of multispecific organic anion and cation transporters, such as organic anion transporter...
386.

Changes of Afferent Transmission to the SI Cortex by Transient Co-Stimulation of Receptive Field Center and Outside in Anesthetized Rats

Yu-MiYang, SabinaLim, Chung-KilWon, Hyung-CheulShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 4 27-32 (6 pages)

Yu-MiYang, SabinaLim, Chung-KilWon, Hyung-CheulShin 저
...
- 3,000원
We have characterized the aftereffects of impulse activities on the transmission of afferent sensory to the primary somatosensory (SI) cortex of the anesthetized rats (n=22). Following conditioning stimulation (CS, 10 sec, either 5 Hz or 200 Hz) to the receptive field (RF), quantitative determination of the changes of afferent sensory transmission was done by generating post-stimulus time histogram of unit response to the testing stimulation (TS, at 0.5 Hz) to the RF center (RFC) for 60 min. In...
387.

Changes of the Level of G Protein α-subunit mRNA by Withdrawal from Morphine and Butorphanol

SeikwanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 4 291-299 (9 pages)

SeikwanOh 저
...
- 3,000원
Morphine or butorphanol was continuously infused into cerebroventricle (i.c.v.) with the rate of 26 nmol/ μl/h for 3 days, and the withdrawal from opioid was rendered 7 hrs after the stopping of infusion. The expression of physical dependence produced by these opioids was evaluated by measuring the naloxone- precipitated withdrawal signs. The withdrawal signs produced in animals dependent on butorphanol (kappa opioid receptor agonist) were similar to those of morphine (mu opioid receptor...
388.

Effects of p-Chlorophenylalanine on the Synthesis of Pancreatic Amylase in Rats

HyeokYilKwon, WonSikEum, HyunWooJang, YunLyulLee, HyoungJinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.2 7 129-135 (7 pages)

HyeokYilKwon, WonSikEum, HyunWooJang, YunLyulLee, HyoungJinPark 저
...
- 3,000원
that p-chlorophenylalanine (PCPA), a serotonin depletor, profoundly increased pancreatic fluid and bicarbonate secretion but remarkably inhibited pancreatic amylase secretion in anesthetized rats. The present study was performed to verify the detailed effects of PCPA on pancreatic amylase synthesis that is directly related to amylase exocrine secretion. PCPA significantly decreased pancreatic RNA and protein contents as well as the amylase activity. However, pancreatic DNA content, trypsin and...
389.

Effect of Capsaicin on Delayed Rectifier K+ Current in Adult Rat Dorsal Root Ganglion Neurons

JunghyunHahn, SungkwonChung, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 2 9-14 (6 pages)

JunghyunHahn, SungkwonChung, HyoweonBang 저
...
- 3,000원
K⁢ currents play multiple roles in the excitability of dorsal root ganglion (DRG) neurons. Influences on these currents change the shape of the action potential, its firing threshold and the resting membrane potential. In this study, whole cell configuration of patch clamp technique had been applied to record the blocking effect of capsaicin, a lipophilic alkaloid, on the delayed rectifier K⁢ current in cultured small diameter DRG neurons of adult rat. Capsaicin reduced the...
390.

Role of Protein Kinases on NF-κB Activation and Cell Death in Bovine Cerebral Endothelial Cells

YoungSooAhn, ChulHoonKim, JooHeeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 2 11-18 (8 pages)

YoungSooAhn, ChulHoonKim, JooHeeKim 저
...
- 3,000원
Nuclear factor κB (NF-κB) activation is modulated by various protein kinases. Activation of NF-κB is known to be important in the regulation of cell viability. The present study investigated the effect of inhibitors of protein tyrosine kinase (PTK), protein kinase C (PKC) and protein kinase A (PKA) on NF-κB activity and the viability of bovine cerebral endothelial cells (BCECs). In serum-deprivation-induced BCEC death, low doses of TNFα showed a protective effect. TNFα induced NF-κB...

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