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Korean Red Ginseng Water Extract Restores Impaired Endothelial Function by Inhibiting Arginase Activity in Aged Mice
KwanhoonChoi, JeongyeonYoon, HyunKyoLim, SungwooRyoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 2 95-102 (8 pages)
Cardiovascular disease is the prime cause of morbidity and mortality and the population ages that may contribute to increase in the occurrence of cardiovascular disease. Arginase upregulation is associated with impaired endothelial function in aged vascular system and thus may contribute to cardiovascular disease. According to recent research, Korean Red Ginseng water extract (KRGE) may reduce cardiovascular disease risk by improving vascular system health. The purpose of this study was to... -
A Computational Model of Cytosolic and Mitochondrial [Ca2+] in Paced Rat Ventricular Myocytes
JaeBoumYoum, SeongWooChoi, ChangHanJang, HyoungKyuKim, ChaeHunLeem, NariKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 23 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 5 217-239 (23 pages)
We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca2+ transients and compared the results with those from computer simulation. In rat ventricular myocytes, increasing the rate of stimulation (1∼3 Hz) made both the diastolic and systolic [Ca2+] bigger in mitochondria as well as in cytosol. As L-type Ca2+ channel has key influence on the amplitude of Ca2+-induced Ca2+ release, the relation between stimulus frequency and the... -
Myoplasmic [Ca2+], Crossbridge Phosphorylation and Latch in Rabbit Bladder Smooth Muscle
Young-DonKim, Min-HyungCho, Seong-ChunKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 8 171-177 (7 pages)
Tonic smooth muscle exhibit the latch phenomenon: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and cellular activation in phasic smooth muscle are unknown. The present study was to determine whether Ca2+-stimulated MRLC phosphorylation could suffice to explain the agonist- or high K+-induced contraction in a fast, phasic smooth muscle. We measured myoplasmic [Ca2+], MRLC... -
Dietary Ascorbate Supplementation Reduces Oxidative Tissue Damage and Expression of iNOS in the Kidney of Streptozotocin Induced Diabetic Rats
MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 8 39-45 (7 pages)
Reactive oxygen species (ROS) have been suggested to be contributory factors in complications of diabetes mellitus. In the present study, we investigated the generation of superoxide, the lipid peroxide level measured as thiobarbituric acid reactive substances, the vasorelaxation of isolated thoracic aorta and the iNOS expression in kidney of streptozotocin induced diabetic rats. Sprague Dawley rats were divided into four groups: control, ascorbate (400 mg/kg rat weight daily in drinking water),... -
Cardiac Response to Head-Out Water Immersion in Man
JangKyuChoi, Won-KunPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 10 253-261 (9 pages)
and the indices of peak velocity and peak acceleration of aortic blood flow were all increased by ∼30%, indicating that the left ventricular contractile force was enhanced by immersion. These results suggest that the increase in stroke volume during immersion is characterized by an increase in ventricular ejection time and aortic blood flow velocity, which may be primarily attributed to the increased cardiac preload and the muscle length-dependent increase in myocardial contractile force. -
Characteristics of Hypoxic Pulmonary Vasoconstriction of the Rat Study by the Vessel Size and Location in the Lung
Sang-JinLeeKiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 10 321-328 (8 pages)
Pulmonary blood vessels with diameters of 200∼400 μm produce considerably more force in response to vasoconstrictor drugs than those which are either smaller or larger. We have therefore investigated whether or not hypoxic pulmonary vasoconstriction (HPV) is more powerful in vessels of these diameters. We have also looked at the possibility that vessels from different regions of the lung respond differently. To do this we have grouped vessels according to their location within the lung as well... -
치매 선별을 위한 한국어판 간이 Blessed 검사의 신뢰도 및 타당도
이동영, 윤종철, 이강욱, 주진형, 김기웅, 이정희, 우종인 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 1999, 제 38권 제 6호 16 1365-1375 (11 pages)
연구목적: 저자들은 치매 환자의 임상 진료 및 역학적 조사 연구에서 간편하면서도 유용하게 사용될 수 있는 치매 선 별용 인지기능 검사 도구인 Short Blessed Test(SBT)를 한국어로 번안하고, 번안된 검사에 대한 신뢰도와 타당도를 검증함으로써 한국어판 SBT(SBT-K)를 개발하고자 하였다. 방 법: 번역-역번역의 과정을 거쳐 번안된 SBT-K를 The Korean Version of Blessed Dementia Scale-Activity of Daily Living(BDS-ADL-K) 및 Clinical Dementia Rating Scale(CDR)과 함께 치매환자 224명과 정상인 191명에게 시행하고, 이들 중... -
치매 선별을 위한 한국어판 하세가와 치매척도의 신뢰도와 타당도
김기웅, 이동영, 안소연, 주진형, 길영남 대한신경정신의학회 신경정신의학 12 Pages
대한신경정신의학회 신경정신의학 2002, 제 41권 제 3호 14 526-537 (12 pages)
연구목적: 치매 환자의 선별과 중증도 평가에 간편하면서도 유용하게 사용할 수 있는 인지기능 검사도구인 개 정 하세가와 치매척도(HDS-R)를 한국어로 반안하고, 번안된 검사에 대한 신뢰도와 타당도를 검증 하여 한국어판 하세가와 치매척도(HDS-K)를 개발하고자 하였다. 방 법: 원본인 HDS-R의 구성을 유지하여 HDS-K로 번안하여 174명의 치매 환자와 160명의 정상 노인 에게 시행하였다. 내적 일치도를 나타내는 Crohnbach alpha 계수와, 검사자간 신뢰도와 검사-재검사 신뢰도를 분석하였다. 또 MMSE-KC, SBT-K 및 CDR을 함께...


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