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Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders
LeeyupChung, AlexraL.Bey, Yong-HuiJiang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 1 369-378 (10 pages)
Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and to find therapeutic targets. Abnormalities of specific types of synaptic plasticity have been revealed in numerous genetically modified mice that have molecular construct validity to human autism spectrum disorders. Constrained by the feasibility of technique, the common regions... -
5-Hydroxytryptamine Inhibits Glutamatergic Synaptic Transmission in Rat Corticostriatal Brain Slice
HyeongSeokCho, SeJoonChoi, Ki-JungKim, HyunHoLee, SeongYunKim, YoungJinCho, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 1 255-262 (8 pages)
Striatum is involved in the control of movement and habitual memory. It receives glutamatergic input from wide area of the cerebral cortex as well as an extensive serotonergic (5-hydroxytryptamine, 5-HT) input from the raphe nuclei. In our study, the effects of 5-HT on synaptic transmission were studied in the rat corticostriatal brain slice using in vitro whole-cell recording technique. 5-HT inhibited the amplitude as well as frequency of spontaneous excitatory postsynaptic currents (sEPSC)... -
Correlation between mEPSC Amplitude and Rise Time upon the Blockade of AMPA Receptor Desensitization at Hippocampal Synapses
SuHyunJung, SukwooChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 3 81-86 (6 pages)
Conventional views of synaptic transmission generally overlook the possibility of "postfusional- control" the regulation of the speed or completeness of transmitter release upon vesicular fusion. However, such regulation often occurs in non-neuronal cells where the dynamics of fusion-pore opening is critical for the speed of transmitter release. In case of synapses, the slower the transmitter release, the smaller the size and rate-of-rise of postsynaptic responses would be expected if... -
정신과 질환에서의 광범위 유전체 연합연구
김세주, 홍경수 대한신경정신의학회 신경정신의학 19 Pages
대한신경정신의학회 신경정신의학 2011, 제 50권 제 1호 4 20-38 (19 pages)
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토끼심장의 전기적 활동에 대한 갑상선 호르몬의 영향
홍성근(Hong, Seong-Geun), 권종국(Kwun, Jong-Kuk), 정순일(Chung, Soon-Il) 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1986, 제 20권 제 1호 3 17-30 (14 pages)
갑상선 호르몬의 표적기관(target organ) 중의 하나인 심장이 hyperthyroid상태에서 심박동수의 증가, 부정맥 그리고 세포 수들에서 sodium, potassium pump기능이 항진되는 것으로 보고되고 있다. 증진된 Pump기능과 더불어 positive chronotropic effect는 심장의 향도잡이로 알려진 동방결절 과 심방근에 어떤 변화에 의하여 발현되는지 알아보기 위하여 3 ~ 6개월령의 토끼 (체중 약 1.5kg내외)에 3,3 ,5-l-triiodothyronine(T3)을 투여하며 실험적으로 hyperthyroid상태를 유도한 다음 심장세포 내에 유리미세전극을 삽입하여 기록한...


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