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Effects of Anticonvulsants on Acute and Tonic Pains in the Rat
Shin, Hong-Kee 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 10 97-104 (8 pages)
days at the dose of 20 mg/Kg/day. Also studied were the effects of strychnine and picrotoxin (1 mg/Kg, i.p.) on the CBZ-produced changes in the formalin-induced pain behaviors. The tail flick and hot plate ltencies were not changes after administration of DPH and CBZ. However DPH strongly suppressed the formalin-induced tonic pain. A single and the repeated administration of CBZ inhibited both the early phasic and the late tonic pain responses to formalin in n similar manner. On the other hand,... -
Effects of Adenosine on the Ionic Channel Activated by Metabolic Inhibition in Rabbit Ventricular Myocytes
Han, Jin, Kim, Eui-Yong, Ho, Won-Kyung, Earm, Yung-E 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1996, 제 30권 제 1호 1 1-10 (10 pages)
The objective of the present study was to characterize the role of adenosine in regulation of ATP-sensitive K+ channel (KATP channel) activity in isolated rabbit ventricular myocytes using the patch clamp technique. Internal adenosine had little effects on KaTr channel activity. In an outside-out patch with intrapipette GTP and ATP, external adenosine stimulated KATP channel activity. In an inside-out Patch with intrapipette adenosine, ATP reduced KATP channel activity, and GTP stimulated KATP... -
Enhanced Efficacy of the Commissural Transmission between Lateral Giants in the Sensitization of Crayfish Escape Behavior
C.Lee, Sun-Hee 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 11 291-300 (10 pages)
Lateral giant (LG)-mediated escape response of crayfish is sensitized by natural traumatic events. Such sensitization has previously been shown to be associated with increased transmission between primary afferents and sensory interneurons at the cholinergic synapse of LG escape reflex circuit. In the present study, it was firstly investigated as to whether transmission is also altered at other synapses of the LG-escape reflex circuit by traumatic shock-induced sensitization. Evidence that... -
Inositol 1,4,5-Trisphosphate-induced Increase in Ca2+-ATPase Activity in the Microsomes of Tracheal Epithelial Cells
Cho, Hyoung-Jin, Park, Sung-Shin, Kim, Young-Kee 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 9 269-278 (10 pages)
Membrane vesicles were prepared by differential centrifugation from epithelial cells of porcine trachea. Total activity of microsomal ATPases was measured spectrophotometrically by a coupled enzyme assay. The steady-state activity of the enzyme was 329±10 nmol/min mg protein. Thapsigargin, a specific antagonist of intracellular Ca2+-ATPase, inhibited about 50% of the activity, leaving 178±18 nmol/min .mg protein (n=6), indicating that the Ca2+-ATPase is one of the major microsomal ATPases.... -
Effects of Ethanol on Neurohumoral Mechanisms for Blood Pressure Regulation in Hemorrhaged Conscious Rats
Park, Yoon-Yub, Park, Jae-Sik, Lee, Won-Jung 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 9 91-102 (12 pages)
to the normal level, but this was markedly retarded by prolactin injection. 5. Direction of Li+ movement was correlated with the change in [Na+] but it always moved out of the amniotic sac even when the [Na+] increased in vasopressin injected AF. From the above results, it is suggested that vasopressin in the AF triggers the fetus to urinate, and then the membranes surrounding the AF regulate osmolarity by efflux of Na+. We suggest that prolactin facilitates water outflow across the amniotic... -
Properties of Single K+ Channels of Skeletal Muscle Incorporated into Planar Lipid Bilayer
Park, Jin-Bong, Kim, Hee-Jeong, Cho, Myung-Haing, Lee, Hang, Park, Hong-Ki, Lee, Mun-Han, Ryu, Pan-Dong 대한생리학회 대한생리학회지 16 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 2 13-28 (16 pages)
single K+ channels of skeletal muscle from the rat and frog were into planar lipid bilayers and their properties were studied. Fusion was induced by an osmotic gradient. Of the four types of K+ channels recorded, the two most frequently observed were a voltage and Ca2+-activated K+ channel and a K+ channel with a prominent conductance substate. The first K+ channel was identified as the large Ca2+-activated K+ (BK) channel because the open-state probability was increased with depolarization... -
Calcium Current in the Unfertilized Egg of the Hamster
Haan, Jae-Hee, Cho, Soo-Wan, Yang, Young-Sun, Park, Young-Geun, Park, Hong-Gi, Chang, Gyeong-Jae, Kim, Yang-Mi, Park, Choon-Ok, Hong, Se 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 12 215-224 (10 pages)
The presence of a calcium current (iCa2+) passed via a specific channel was examined in the unfertilized hamster egg using the whole-cell voltage clamp technique. Pure inward current was isolated using a Ca2+-rich pipette solution containing 10 mM TEA. This current was independent of external Na+ and was highly sensitive to the Ca2+ concentration in the bathing solution, indicating that the inward current is carried by Ca2+. The maximal amplitude was -4.12±0.58nA (n=12) with 10mM Ca2+ at -3OmV... -
Effect of pH on the Vascular Tone and 45Ca Uptake in the Aorta of Spontaneously Hypertensive Rats
Chang, Seok-Jong, Jeon, Byeong-Hwa, Kim, Se-Hoon, Kim, Hoe-Suk, Park, Hae-Kun 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 2호 7 169-180 (12 pages)
~ 8.3 was estimated by comparison with the level of vascular tone at pH 7.4. Contraction was induced below pHo 6.5 in WKY, pHo 7.1 in SHR, and over pHo 8.0 on both strains. The amplitude of contraction induced by high pHo (over pHo 7.7) was similar in SHR and WKY, but that induced by low pHo (below pHo 7.1) in SHR was greater than that in WKY. Either high pHo- or low pHo-induced contractions in WKY and SHR were not induced in the Ca-free Tyrode s solution and were induced by the addition of Ca.... -
Effects of Lemakalim, a Potassium Channel Opener, on the Contractility and Electrical Activity of the Antral Circular Muscle in Guinea-Pig Stomach
Kim, Sung-Joon, Jun, Jae-Yeoul, Choi, Youn-Baik, Kim, Ki-Whan, Kim, Woo-Gyeum 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 1호 4 37-50 (14 pages)
Synthetic potassium channel openers (KCOs) are agents capable of opening K-channels in excitable cells. These agents are known to have their maximal potency in the smooth muscle tissue, especially in the vascular smooth muscle. Much attention has been focused on the type of K-channel that is responsible for mediating the effects of KCOs. As the KCO-induced changes are antagonized by glibenclamide, an KATP (ATP-sensitive K-channel) blocker in the pancreatic β-cell, KATP was suggested to be the... -
Ca-dependent Alteration in Basal Tone, Basal 45Ca Uptake and 3H-nitrendipine Binding in the Aorta of Spontaneously Hypertensive Rats
Chang, Seok-Jong, Jeon, Byeong-Hwa, Kim, Hoe-Suk 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1994, 제 28권 제 1호 3 27-36 (10 pages)
We investigated the alterations in basal tone of aortic strips by changing the Ca concentration, basal 45Ca uptake and 3H-nitrendipine binding of the single cells of aortic smooth muscles in the spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. While the basal tone of the aortic strips in WKY rats was not affected by alteration of Ca concentration, that in SHR was decreased by the removal of Ca from the bath solution and was recovered by the restoration of Ca to normal levels....


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