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391.

Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains

Keun-SungLee, Jin-KooLee, Hyung-GunKim, HakRimKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 13 89-97 (9 pages)

Keun-SungLee, Jin-KooLee, Hyung-GunKim, HakRimKim 저
...
- 3,000원
Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before human application. However, which of the plethora of experimental animal species to use in model development can be perplexing. Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a very well known method to induce the symptoms of Parkinson's disease in mice. But, there is very limited...
392.

Protective Effect of ECQ on Rat Reflux Esophagitis Model

Hyeon-SoonJang, JeongHoonHan, JunYeongJeong, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 12 455-462 (8 pages)

Hyeon-SoonJang, JeongHoonHan, JunYeongJeong, UyDongSohn 저
...
- 3,000원
This study was designed to determine the protective effect of Rumex Aquaticus Herba extracts containing quercetin-3-Ղ-D-glucuronopyranoside (ECQ) on experimental reflux esophagitis. Reflux esophagitis was induced by surgical procedure. The rats were divided into seven groups, namely normal group, control group, ECQ (1, 3, 10, 30 mg/kg) group and omeprazole (30 mg/kg) group. ECQ and omeprazole groups received intraduodenal administration. The Rats were starved for 24 hours before the...
393.

Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1b in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 11 447-453 (7 pages)

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 저
...
- 3,000원
activated protein kinases and activation of protein kinase C. Treatment with pharmacological inhibitors, including SB202190, SP6001250, U0126, Akt inhibitor IV, LY294002, GF109203X, and RO318220 resulted in significantly attenuated FSL-1-mediated upregulation of CCL2 and IL-1Ղ. Our results indicate that activation of TLR6 will trigger inflammatory responses by upregulating expression of CCL2 and IL-1Ղ via TLR-2/4, protein kinase C, PI3K-Akt, and mitogen-activated protein kinases.
394.

Mechanisms of Motility Change on Trinitrobenzenesulfonic Acid- Induced Colonic Inflammation in Mice

GabJinCheon, YuanCui, Dong-SooYeon, Seong-ChunKwon, Byong-GonPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 10 437-446 (10 pages)

GabJinCheon, YuanCui, Dong-SooYeon, Seong-ChunKwon, Byong-GonPark 저
...
- 3,000원
Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by recurrent episodes of colonic inflammation and tissue degeneration in human or animal models. The contractile force generated by the smooth muscle is significantly attenuated, resulting in altered motility leading to diarrhea or constipation in IBD. The aim of this study is to clarify the altered contractility of circular and longitudinal smooth muscle layers in proximal colon of trinitrobenzen sulfonic acid...
395.

Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats

JiSooChoi, JoongWooLeem, KyungHeeLee, Sung-SooKim, HaeyoungSuh-Kim, SeJungJung, UnJengKim, BaeHwanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 6 405-411 (7 pages)

JiSooChoi, JoongWooLeem, KyungHeeLee, Sung-SooKim, HaeyoungSuh-Kim, SeJungJung, UnJengKim, BaeHwanLee 저
...
- 3,000원
The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration that avoids the ethical issues associated with embryonic stem cell transplantation. As SCI is a complex pathological entity, the treatment of SCI requires a multipronged approach. The purpose of the present study was to investigate the functional recovery and therapeutic...
396.

Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase

Hyun-eLee, Eun-HyunKim, Hye-RyungChoi, UyDongSohn, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Kyoung-ChanPark, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 9 287-291 (5 pages)

Hyun-eLee, Eun-HyunKim, Hye-RyungChoi, UyDongSohn, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Kyoung-ChanPark, Dong-SeokKim 저
...
- 1,500원
study also described here, the effects of these dipeptides on melanogenesis-related signal transduction were quantified. Specifically, PS and VS induced ERK phosphorylation, though they had no effect on phosphorylation of the cAMP response element binding protein (CREB). These data suggest that PS and VS inhibit melanogenesis through ERK phosphorylation and subsequent down-regulation of MITF and tyrosinase. Properties of these dipeptides are compatible with application as skin-whitening agents.
397.

Comparison of Neurite Outgrowth Induced by Erythropoietin (EPO) and Carbamylated Erythropoietin (CEPO) in Hippocampal Neural Progenitor Cells

DongHoonOh, InYoungLee, MiyeonChoi, SeokHyeonKim, HyeonSon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 8 281-285 (5 pages)

DongHoonOh, InYoungLee, MiyeonChoi, SeokHyeonKim, HyeonSon 저
...
- 1,500원
the subgranular zone (SGZ) compared to that in vehicle-treated controls. Functional differentiation studies using dissociated hippocampal cultures revealed that EPO treatment also increased the number of double-labeled BrdU/microtubule- associated protein 2 (MAP2) neurons compared to those in vehicle-treated controls. Both EPO and CEPO treatment significantly increased the length of neurites and spine density in MAP2(+) cells. In summary, these results provide evidences that EPO and CEPO promote...
398.

Yoga Training Improves Metabolic Parameters in Obese Boys

DaeYunSeo, SungRyulLee, ArturoFigueroa, HyoungKyuKim, YeongHoBaek, YiSubKwak, NariKim, TaeHoonChoi, ByoungDooRhee, KyungSooKo, ByungJooPar 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 4 175-180 (6 pages)

DaeYunSeo, SungRyulLee, ArturoFigueroa, HyoungKyuKim, YeongHoBaek, YiSubKwak, NariKim, TaeHoonChoi, ByoungDooRhee, KyungSooKo, ByungJooPar 저
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- 3,000원
Yoga has been known to have stimulatory or inhibitory effects on the metabolic parameters and to be uncomplicated therapy for obesity. The purpose of the present study was to test the effect of an 8-week of yoga-asana training on body composition, lipid profile, and insulin resistance (IR) in obese adolescent boys. Twenty volunteers with body mass index (BMI) greater than the 95th percentile were randomly assigned to yoga (age 14.7±0.5 years, n=10) and control groups (age 14.6±1.0 years,...
399.

Cilostazol Decreases Ethanol-Mediated TNFalpha Expression in RAW264.7 Murine Macrophage and in Liver from Binge Drinking Mice

YounJuLee, JongRyeolEun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 8 131-138 (8 pages)

YounJuLee, JongRyeolEun 저
...
- 3,000원
LPS-stimulated TNFՁ mRNA and protein with a similar degree to that by pentoxifylline. Cilostazol increased the basal AMP- activated protein kinase (AMPK) activity as well as normalized the decreased AMPK by LPS. AICAR, an AMPK activator and db-cAMP also significantly decreased TNFՁ production in RAW264.7 cells, but cilostazol did not affect the levels of intracellular cAMP and reactive oxygen species (ROS) production. The in vivo effect of cilostazol was examined using ethanol binge...
400.

Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex

Sung-WonPark, Hyun-JongJang, Kwang-HyunCho, , Myung-JunKim, ShinHeeYoon, Duck-JooRhie 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 10 65-70 (6 pages)

Sung-WonPark, Hyun-JongJang, Kwang-HyunCho, , Myung-JunKim, ShinHeeYoon, Duck-JooRhie 저
...
- 3,000원
Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP and LTD during the critical period of the rat visual cortex (postnatal 3∼5 weeks). However, in adult rats, the increase in 5-HT level in the brain by the administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine reinstates ocular dominance plasticity...

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