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391.

Noradrenergic Modulation of Spontaneous Inhibitory Postsynaptic Currents in the Hypothalamic Paraventricular Nucleus

LongHwaLee, WoneeChong, KihoLee, JinBongPark, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 2 71-80 (10 pages)

LongHwaLee, WoneeChong, KihoLee, JinBongPark, PanDongRyu 저
...
- 3,000원
value (4.4⁑0.8 Hz, p＜0.001). This effect was blocked by yohimbine (2∼20μM), an α2-adrenoceptor antagonist and mimicked by clonidine (50μM), an α2-adrenoceptor agonist. In contrast, NE increased sIPSC frequency to 248⁑32% of the control (3.06⁑0.37 Hz, p＜0.001) in 31 of 54 type II neurons, but decreased the frequency to 41⁑7% of the control (5.5⁑1.3 Hz) in the rest of type II neurons (p＜0.001). In both types of PVN neurons, NE did not affect the mean amplitude...
392.

Nimodipine as a Potential Pharmacological Tool for Characterizing R-Type Calcium Currents

SeogBaeOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 8 511-519 (9 pages)

SeogBaeOh 저
...
- 3,000원
Ca currents, blocked high-voltage-activated calcium channel currents by ∼38%. Interestingly, high concentrations of nimodipine (＞10μM) further reduced the "residual" currents in DRG neurons from α1E knock-out mice, after blocking L-, N- and P/Q-type Ca currents with 10μM nimodipine, 1μM ω-conotoxin GVIA and 200 nM ω-agatoxin IVA, indicating inhibitory effects of nimodipine on R-type Ca currents. Nimodipine (＞10μM) also produced the inhibition of both low-voltage-activated...
393.

Forward-Mode Na+-Ca2+ Exchange during Depolarization in the Rat Ventricular Myocytes with High EGTA

Eun-GiKim, ChangMannKo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 5 487-494 (8 pages)

Eun-GiKim, ChangMannKo 저
...
- 3,000원
The I∼V relationship of the caffeine-induced current elicited inward current from ⁣45 mV to ⁢3 mV with the peak at ⁣25 mV. Taken together, it is concluded that, during activation of the rat ventricular myocyte, forward-mode Na⁢-Ca2⁢ exchange extrudes a fraction of Ca2⁢ released from sarcoplasmic reticulum mainly by voltage-sensitive release mechanism in a micro-domain in the t-tubule, which is functionally separable from global Ca2⁢i by EGTA.
394.

The Inhibitory Effect of Opioid on the Hyperpolarization-Activated Cation Currents in Rat Substantia Gelatinosa Neurons

GeunHeeSeol, JunKim, SunHeeCho, WonKiKim, JongWhanKim, SangJeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 2 373-380 (8 pages)

GeunHeeSeol, JunKim, SunHeeCho, WonKiKim, JongWhanKim, SangJeongKim 저
...
- 3,000원
cation current (Ih) in substantia gelatinosa neurons were investigated by using whole-cell voltage-clamp recording in rat spinal brain slices. Hyperpolarizing voltage steps revealed slowly activating currents in a subgroup of neurons. The half-maximal activation and the reversal potential of the current were compatible to neuronal Ih. DAMGO (1μM), a selective- opioid agonist, reduced the amplitude of Ih reversibly. This reduction was dose-dependent and was blocked by CTOP (2μM), a selective...
395.

Activation of ATP-sensitive Potassium Channels by the Predominant Metabolite of Isoflurane in Rabbit Ventricular Myocytes

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 7 165-175 (11 pages)

JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 저
...
- 4,000원
Background: Recent in vivo experimental evidence suggests that isoflurane-induced cardioprotection may involve KATP channel activation. However, it was demonstrated that isoflurane inhibited KATP channel activities in the inside-out patch mode. To explain this discrepancy, the present investigation tested the hypothesis that a metabolite of isoflurane, trifluoroacetic acid (TFA), contributes to isoflurnae-induced cardioprotection via KATP channel activation during myocardial ischemia and...
396.

Altered Delayed Rectifier K+ Current of Rabbit Coronary Arterial Myocytes in Isoproterenol-Induced Hypertrophy

NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 5 33-40 (8 pages)

NariKim, JinHan, EuiyongKim 저
...
- 3,000원
The aim of present study was to define the cellular mechanisms underlying changes in delayed rectifier K⁢ (KDR) channel function in isoproterenol-induced hypertrophy. It has been proposed that KDR channels play a role in regulation of vascular tone by limiting membrane depolarization in arterial smooth muscle cells. The alterations of the properties of coronary KDR channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present...
397.

N-Type Calcium Channels

KeithS.Elmslie 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 12 525-530 (6 pages)

KeithS.Elmslie 저
...
- 3,000원
The early studies of cardiac and smooth muscle cells provided evidence for two different calcium channels, the L-type (also called high-voltage activated [HVA]) and the T-type (low-voltage activated [LVA]). These calcium channels provided calcium for muscle contractions and pace-making activities. As might be expected, the number of different calcium channels increased when researchers studied neurons and the identification of the neuronal calcium channel has proven to be much more difficult...
398.

The Effect of Carbon Monoxide on Contraction, Cytosolic Ca2+ Level and Ionic Currents in Guinea Pig Ileal Smooth Muscle

SeongChunKwon, SeungSooChung, YunSukKim, TaickSangNam 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 6 471-477 (7 pages)

SeongChunKwon, SeungSooChung, YunSukKim, TaickSangNam 저
...
- 3,000원
a holding potential of ⁣60 mV, we found that CO had little effect on the peak Ba currents (IBa) when voltage was stepped from ⁣60 mV to 0 mV. In addition, CO showed no effect on the depolarization-activated outward K⁢ currents in the all potential ranges. We conclude that CO inhibits smooth muscle contraction mainly by decreasing the Ca2⁢ sensitivity of contractile elements via a cGMP-dependent pathway, not by involving L-type Ca2⁢ and outward-potassium currents in...
399.

Zn2+ Modulates the Responses of Rat Dorsal Horn Neuron to C-Fiber Stimulation and Excitatory Amino Acids

ChangHoonAhn, HongKeeShin, JinHyukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 3 445-453 (9 pages)

ChangHoonAhn, HongKeeShin, JinHyukKim 저
...
- 3,000원
Zinc contained in the neurons of central nervous system is activity-dependently released and then attenuates NMDA (N-methyl-D-aspartate)-induced neurotoxicity while augmenting non-NMDA-induced neurodegeneration. Zinc also has been reported to produce antinociceptive action on the inflammation- and nerve injury-induced hyperalgesia in the behavioral test. In this study, we investigated the effects of zinc on the responses of dorsal horn cells to NMDA, kainate and graded electrical stimulation of...
400.

Stationary Outward and Transient Ca2+-Dependent Currents in Hamster Oocytes

Yang-MiKim, Jae-HeeHan, Jong-SuKim, Seong-GeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 9 403-408 (6 pages)

Yang-MiKim, Jae-HeeHan, Jong-SuKim, Seong-GeunHong 저
...
- 3,000원
inward Ca2⁢ current (ICa), and its current-voltage (I-V) relation was a mirror image of that of ICa. Either blockade of ICa by Co2⁢ or replacement of Ca2⁢ with Sr2⁢ abolished Ito without change in I∞. Intracellular EGTA (10 mM) inhibited Ito but not I∞. suggesting strongly that generation of Ito requires intracellular Ca2⁢. Apamin (1 nM) abolished selectively Ito, indicating that Ito is Ca2⁢-dependent K⁢ current. On the other hand, I∞ was Ca2⁢-...

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