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461.

Activation of G Proteins by Aluminum Fluoride Enhances RANKL- Mediated Osteoclastogenesis

BoryungPark, Yu-MiYang, Byung-JaiChoi, MinSeukKim, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 8 427-433 (7 pages)

BoryungPark, Yu-MiYang, Byung-JaiChoi, MinSeukKim, DongMinShin 저
...
- 3,000원
Receptor activator of NF-ՊB ligand (RANKL)-induced osteoclastogenesis is accompanied by intra-cellular Ca2＋ mobilization in a form of oscillations, which plays essential roles by activating sequen-tially Ca2＋/calmodulin-dependent protein kinase, calcineurin and NFATc1, necessary in the osteoclast differentiation. However, it is not known whether Ca2＋ mobilization which is evoked in RANKL-in-dependent way induces to differentiate into osteoclasts. In present study, we investigated Ca2＋...
462.

Ineffective Doses of Dexmedetomidine Potentiates the Antinoci-ception Induced by Morphine and Fentanyl in Acute Pain Model

MuminUnal, SinanGursoy, AhmetAltun, CevdetDuger, IclalOzdemirKol, KenanKaygusuz, IhsanBagcivan, CanerMimaroglu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 6 417-422 (6 pages)

MuminUnal, SinanGursoy, AhmetAltun, CevdetDuger, IclalOzdemirKol, KenanKaygusuz, IhsanBagcivan, CanerMimaroglu 저
...
- 3,000원
The aim of this study was to evaluate the synergistic potentiation effect of ineffective doses of dexmedetomidine on antinociception induced by morphine and fentanyl in acute pain model in rats. Seventy albino Wistar rats were separated into 7 groups. Data for the control and sham groups were recorded. The ineffective dose of dexmedetomidine was investigated and found to be 3 Ռg/kg. Each group was administered the following medications: 3 mg/kg morphine (intraperitoneal) to Group 3, 5...
463.

Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M. gerbils

Young-NaHur, JoonLee, Seung-ChanSohn, Chung-GilWon, Hyung-HaLee, Dong-HoonKim, Sang-HyunChoi, Kyung-HoShin, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 4 405-409 (5 pages)

Young-NaHur, JoonLee, Seung-ChanSohn, Chung-GilWon, Hyung-HaLee, Dong-HoonKim, Sang-HyunChoi, Kyung-HoShin, Boe-GwunChun 저
...
- 1,500원
We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5 mg/kg: NT-0.5) slightly reduced ePSA in males but markedly augmented that in females. Acute NT (5.0 mg/kg) markedly increased the ePSA in all gerbils. Unlike acute NT-0.5, repeated NT-0.5 injection (twice a day for 7 days) significantly increased the ePSA in males and slightly affected the NT-0.5...
464.

Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats

BombiLee, BongjunSur, JinheePark, Sung-HunKim, SunohKwon, MijungYeom, InsopShim, HyejungLee, Dae-hyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 3 393-403 (11 pages)

BombiLee, BongjunSur, JinheePark, Sung-HunKim, SunohKwon, MijungYeom, InsopShim, HyejungLee, Dae-hyunHahm 저
...
- 4,000원
Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated that repeated restraint stress disrupts the activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. The behavioral and neurochemical basis of the BA effect on depression remain unclear. The present study used the forced swimming test...
465.

Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

SeungHwaHong, RohyunSung, YoungChulKim, HikaruSuzuki, WoongChoi, YeonJinPark, IllWoonJi, ChanHyungKim, SunChulMyung6, MooYeolLee, TongMook 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 14 359-365 (7 pages)

SeungHwaHong, RohyunSung, YoungChulKim, HikaruSuzuki, WoongChoi, YeonJinPark, IllWoonJi, ChanHyungKim, SunChulMyung6, MooYeolLee, TongMook 저
...
- 3,000원
Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K＋ channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K＋ conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular...
466.

Effect of Lutein on L-NAME-Induced Hypertensive Rats

JiHoonSung, YoungSooJo, SuJinKim, JeongSooRyu, MyungChulKim, HyunJuKo, SangSooSim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 12 339-345 (7 pages)

JiHoonSung, YoungSooJo, SuJinKim, JeongSooRyu, MyungChulKim, HyunJuKo, SangSooSim 저
...
- 3,000원
We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3±9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were...
467.

Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment

Soo-JeongKim, Jun-HoLee, Hwan-SuckChung, Joo-HyunSong, JoohunHa, HyunsuBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 11 331-338 (8 pages)

Soo-JeongKim, Jun-HoLee, Hwan-SuckChung, Joo-HyunSong, JoohunHa, HyunsuBae 저
...
- 3,000원
AMP-activated protein kinase (AMPK), an important regulator of energy metabolism, is activated in response to cellular stress when intracellular levels of AMP increase. We investigated the neuroprotective effects of AMPK against scopolamine-induced memory impairment in vivo and glutamate-induced cytotoxicity in vitro. An adenovirus expressing AMPK wild type alpha subunit (WT) or a dominant negative form (DN) was injected into the hippocampus of rats using a stereotaxic apparatus. The AMPK...
468.

Expression and Activity of the Na-K ATPase in Ischemic Injury of Primary Cultured Astrocytes

MiJungKim, JinyoungHur, In-HyeHam, HyeJinYang, YounghoonKim, SeungjoonPark, Young-WukCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 4 275-281 (7 pages)

MiJungKim, JinyoungHur, In-HyeHam, HyeJinYang, YounghoonKim, SeungjoonPark, Young-WukCho 저
...
- 3,000원
Astrocytes are reported to have critical functions in ischemic brain injury including protective effects against ischemia-induced neuronal dysfunction. Na-K ATPase maintains ionic gradients in astrocytes and is suggested as an indicator of ischemic injury in glial cells. Here, we examined the role of the Na-K ATPase in the pathologic process of ischemic injury of primary cultured astrocytes. Chemical ischemia was induced by sodium azide and glucose deprivation. Lactate dehydrogenase assays...
469.

Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs

YuJiCho, ChinOkYi, ByeongTakJeon, YiYeongJeong, GiMunKang, JungEunLee, GuSeobRoh, JongDeogLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 3 267-274 (8 pages)

YuJiCho, ChinOkYi, ByeongTakJeon, YiYeongJeong, GiMunKang, JungEunLee, GuSeobRoh, JongDeogLee 저
...
- 3,000원
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage...
470.

(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion

NadaAl-Ajmi, MayAl-Maghrebi, WaleedMohammedRenno 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 2 259-265 (7 pages)

NadaAl-Ajmi, MayAl-Maghrebi, WaleedMohammedRenno 저
...
- 3,000원
The anti-apoptotic effect of (-)-epigallocatechin-3-gallate (EGCG) during unilateral testicular torsion and detorsion (TT/D) was established in our previous study. In mice, the smallest inhibitor of apoptosis, survivin, is alternatively spliced into three variants, each suggested to have a unique function. Here, we assessed how EGCG exerts its protective effect through the expression of the different survivin splice variants and determined its effect on the morphology of the seminiferous tubules...

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