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471.

Effect of Doxorubicin on Catecholamine Release in the Isolated Perfused Rat Adrenal Gland

Dong-YoonLim, Song-HoonOh, Yoo-SeungSeoh, Eun-SookLee, Il-HwanKim, Seong-HoJo, Soon-PyoHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 7 215-224 (10 pages)

Dong-YoonLim, Song-HoonOh, Yoo-SeungSeoh, Eun-SookLee, Il-HwanKim, Seong-HoJo, Soon-PyoHong 저
...
- 3,000원
The present study was undertaken to investigate the effect of doxorubicin (DX) on secretion of catecholamines (CA) evoked by ACh, high K⁢, DMPP and McN-A-343 from the isolated perfused rat adrenal gland and to establish the mechanism of its action. DX (10⁣7∼10⁣6 M) perfused into an adrenal vein for 60 min produced relatively dose- and time-dependent inhibition of CA secretory responses evoked by ACh (5.32⁓10⁣3 M), DMPP (10⁣4 M) and McN-A-343 (10⁣4 M)....
472.

Influence of Tacrine on Catecholamine Secretion in the Perfused Rat Adrenal Gland

Seok-JeongJang, Won-HoYang, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 6 207-214 (8 pages)

Seok-JeongJang, Won-HoYang, Dong-YoonLim 저
...
- 3,000원
The present study was designed to clarify whether tacrine affects the release of catecholamines (CA) from the isolated perfused model of rat adrenal gland or not and to elucidate the mechanism of its action. Tacrine (3⁓10⁣5∼3⁓10⁣4 M) perfused into an adrenal vein for 60 min inhibited CA secretory responses evoked by ACh (5.32⁓10⁣3 M), DMPP (a selective neuronal nicotinic agonist, 10⁣4 M for 2 min) and McN-A-343 (a selective muscarinic M1-agonist,...
473.

Changes in the Expressional Levels of Sarcoplasmic Reticulum Ca2+-regulatory Proteins in the Postnatal Developing Rat Heart

EunHeeLee, SooSungPark, JaeSungLee, YoungJuSeo, Young-HoonKim, HaeWonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 6 101-108 (8 pages)

EunHeeLee, SooSungPark, JaeSungLee, YoungJuSeo, Young-HoonKim, HaeWonKim 저
...
- 3,000원
In the present study, the postnatal developmental changes in the expressional levels of cardiac sarcoplasmic reticulum (SR) Ca2⁢ regulatory proteins, i.e. Ca2⁢-ATPase, phospholamban, and Ca2⁢ release channel, were investigated. Both SR Ca2⁢-ATPase and phospholamban mRNA levels were about 35% of adult levels at birth and gradually increased to adult levels. Protein levels of both SR Ca2⁢-ATPase and phospholamban, which were measured by quantitative immunoblotting,...
474.

Noradrenergic Modulation of Spontaneous Inhibitory Postsynaptic Currents in the Hypothalamic Paraventricular Nucleus

LongHwaLee, WoneeChong, KihoLee, JinBongPark, PanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 2 71-80 (10 pages)

LongHwaLee, WoneeChong, KihoLee, JinBongPark, PanDongRyu 저
...
- 3,000원
Previous studies have suggested that brain stem noradrenergic inputs differentially modulate neurons in the paraventricular nucleus (PVN). Here, we compared the effects of norepinephrine (NE) on spontaneous GABAergic inhibitory postsynaptic currents (sIPSCs) in identified PVN neurons using slice patch technique. In 17 of 18 type I neurons, NE (30∼100μM) reversibly decreased sIPSC frequency to 41⁑7% of the baseline value (4.4⁑0.8 Hz, p＜0.001). This effect was blocked by yohimbine...
475.

Unchanged Protein Level of Ryanodine Receptor but Reduced [3H] Ryanodine Binding of Cardiac Sarcoplasmic Reticulum from Diabetic Cardiomyopathy Rats

EunHeeLee, YoungJuSeo, Young-HoonKim, HaeWonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 5 397-405 (9 pages)

EunHeeLee, YoungJuSeo, Young-HoonKim, HaeWonKim 저
...
- 3,000원
The ryanodine receptor, a Ca2⁢ release channel of the sarcoplasmic reticulum (SR), is responsible for the rapid release of Ca2⁢ that activates cardiac muscle contraction. In the excitation-contraction coupling cascade, activation of SR Ca2⁢ release channel is initiated by the activity of sarcolemmal Ca2⁢ channels, the dihydropyridine receptors. Previous study showed that the relaxation defect of diabetic heart was due to the changes of the expressional levels of SR...
476.

G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle

UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)

UyDongSohn, DongSeokKim, KarnamSMurthy 저
...
- 4,000원
Contraction of smooth muscle is initiated by an increase in cytosolic Ca2⁢ leading to activation of Ca2⁢/ calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of Ca2⁢ and the kinetic of Ca2⁢ mobilization. Ca2⁢ mobilizing agonists stimulate different...
477.

Role of Protein Kinases on NF-κB Activation and Cell Death in Bovine Cerebral Endothelial Cells

YoungSooAhn, ChulHoonKim, JooHeeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 2 11-18 (8 pages)

YoungSooAhn, ChulHoonKim, JooHeeKim 저
...
- 3,000원
Nuclear factor κB (NF-κB) activation is modulated by various protein kinases. Activation of NF-κB is known to be important in the regulation of cell viability. The present study investigated the effect of inhibitors of protein tyrosine kinase (PTK), protein kinase C (PKC) and protein kinase A (PKA) on NF-κB activity and the viability of bovine cerebral endothelial cells (BCECs). In serum-deprivation-induced BCEC death, low doses of TNFα showed a protective effect. TNFα induced NF-κB...
478.

Modulation of ATP-Induced Activation of the Muscarinic K+ Channel Activity by Protein Kinase C

Yang-MiKim, Hong-KiPark, Jae-HeeHan, Choon-OkPark, Seong-GeunHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 11 743-753 (11 pages)

Yang-MiKim, Hong-KiPark, Jae-HeeHan, Choon-OkPark, Seong-GeunHong 저
...
- 4,000원
The atrial acetylcholine-activated K⁢ (KACh) channel is gated by the pertussis toxin-sensitive inhibitory G (GK) protein. Earlier studies revealed that ATP alone can activate the KACh channel via transphosphorylation mediated by nucleoside-diphosphate kinase (NDPK) in atrial cells of rabbit and guinea pig. This channel can be activated by various agonists and also modulated its function by phosphorylation. ATP-induced KACh channel activation (AIKA) was maintained in the presence of the...
479.

Increased Activity of Large Conductance Ca2+-Activated K+ Channels in Negatively-Charged Lipid Membranes

JinBongParkPanDongRyu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 15 529-539 (11 pages)

JinBongParkPanDongRyu 저
...
- 4,000원
The effects of membrane surface charge originated from lipid head groups on ion channels were tested by analyzing the activity of single large conductance Ca2⁢-activated K⁢ (maxi K) channel from rat skeletal muscle. The conductances and open-state probability (Po) of single maxi K channels were compared in three types of planar lipid bilayers formed from a neutral phosphatidylethanolamine (PE) or two negatively-charged phospholipids, phosphatidylserine (PS) and phosphatidylinositol...
480.

Mechanism of Vasoactive Intestinal Polypeptide-Induced Catecholamine Secretion from the Rat Adrenal Medulla

Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 6 443-454 (12 pages)

Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 저
...
- 4,100원
The present study was attempted to investigate the effect of vasoactive intestinal polypeptide (VIP) on secretion of catecholamines (CA) and to establish whether there is the existence of a noncholinergic mechanism in adrenomedullary CA secretion from the isolated perfused rat adrenal gland. The perfusion into an adrenal vein of VIP (3⁓10⁣6 M) for 5 min or the injection of acetylcholine (ACh, 5.32⁓10⁣3 M) resulted in great increases in CA secretion. Tachyphylaxis to...

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