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전체 선택해제
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본문검색 결과만 보기
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Provinol Inhibits Catecholamine Secretion from the Rat Adrenal Medulla
Jung-HeeLee, Yu-SeungSeo, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 14 229-239 (11 pages)
(a voltage-dependent L-type dihydropyridine Ca2＋ channel activator, 10ՌM), cyclopiazonic acid (a cytoplasmic Ca2＋-ATPase inhibitor, 10ՌM) and veratridine (an activator of voltage-dependent Na＋ channels, 10ՌM) were significantly reduced. Interestingly, in the simultaneous presence of provinol (1Ռg/ml) plus L-NAME (a selective inhibitor of NO synthase, 30ՌM), the CA secretory responses evoked by ACh, high K＋, DMPP, McN-A-343, Bay-K-8644 and cyclpiazonic acid... -
Influence of Ketamine on Catecholamine Secretion in the Perfused Rat Adrenal Medulla
Young-YeobKo, Yong-HoonJeong, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.3 3 101-110 (10 pages)
activator, 100ՌM), Bay-K-8644 (an L-type dihydropyridine Ca2＋ channel activator, 10ՌM), and cyclopiazonic acid (a cytoplasmic Ca2＋-ATPase inhibitor, 10ՌM) were significantly reduced, respectively. Interestingly, thiopental sodium (100ՌM) also caused the inhibitory effects on the CA secretory responses evoked by ACh, high K＋, DMPP, McN-A-343, veratridine, Bay-K-8644, and cyclopiazonic acid. Collectively, these experimental results demonstrate that ketamine inhibits the... -
Glycyrrhizin and Morroniside Stimulate Mucin Secretion from Cultured Airway Epithelial Cells
HoJinHeo, HyunJaeLee, CheolsuKim, KunHoSon, YoungChoongKim, YoungSikKim, SamSikKang, YangChunPark, YunHeeKim, UnKyoSeo, JeongHoSeok, Choong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 4 317-322 (6 pages)
assess the effects on 3H-mucin secretion. The results were as follows: 1) glycyrrhizin and morroniside increased basal mucin secretion from airway; 2) prunetin did not affect basal mucin secretion; 3) glycyrrhizin did not inhibit ATP-induced mucin secretion. We conclude that glycyrrhizin and morroniside can increase basal mucin secretion, by directly acting on airway mucin-secreting cells and suggest that two compounds be further investigated for the possible use as mild expectorants during the... -
Inhibition of Adenosine Triphosphate-stimulated Mucin Secretion from Airway Epithelial Cells by Schizandrin
HoJinHeo, HyunJaeLee, CheolsuKim, KiHwanBae, YoungSikKim, SamSikKang, YangChunPark, YunHeeKim, UnKyoSeo, JeongHoSeok, ChoongJaeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 5 251-254 (4 pages)
the effects on 3H-mucin secretion. The results were as follows: 1) schizandrin significantly inhibited ATP-induced mucin secretion; 2) However, schizandrin-A and gomisin-A did not affect ATP-induced mucin secretion, significantly. We conclude that schizandrin can inhibit ATP- induced mucin secretion by directly acting on airway mucin-secreting cells. Therefore, schizandrin should further be investigated for the possible use as mucoregulators in the treatment of inflammatory airway diseases. -
Naltrexone Inhibits Catecholamine Secretion Evoked by Nicotinic Receptor Stimulation in the Perfused Rat Adrenal Medulla
Byung-SikYu, Seon-YoungMin, Yoo-SeokSeo, Cheol-HeeChoi, Eun-HwaLee, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 6 223-230 (8 pages)
L-type Ca2 channels and cyclopiazonic acid, an inhibitor of cytoplasmic Ca2-ATPase, were also inhibited. However, in the presence of met-enkephalin (5⁓106 M), a well-known opioid agonist, the CA secretory responses evoked by ACh, high K, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were also significantly inhibited. Collectively, these experimental results demonstrate that naltrexone inhibits greatly CA secretion evoked by stimulation of cholinergic (both... -
Helicobacter pylori Vacuolating Toxin Exhibits Polar Activity of Cl- Secretion and Secretory Response to Carbachol in T84 Cells
NanGeJin, YongRiJin, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 8 289-293 (5 pages)
were monitored. Mucosal addition of low pH-pretreated VacA increased short circuit current (Isc). The effect was time- and dose-dependent and saturable. The time-to-peak Isc was concentration-dependent. Chloride channel inhibitors, niflumic acid or 5- nitro-2-(3-phenylpropylamino)-benzoate (NPPB), inhibited VacA-stimulated Isc. Carbachol (CCh)-induced increase of Isc was prolonged by the addition of VacA to the mucosal side only. The effect was unaltered by the addition of niflumic acid. VacA... -
Mechanism of Leptin-Induced Potentiation of Catecholamine Secretion Evoked by Cholinergic Stimulation in the Rat Adrenal Medulla
Dong-YoonLim, Deok-HoChoi, Moo-JinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.4 9 227-235 (9 pages)
of the dihydropyridine L-type Ca2 channels, and cyclopiazonic acid, an inhibitor of cytoplasmic Ca2 ATPase. However, in the presence of U0126 (1μM), an inhibitor of mitogen-activated protein kinase (MAPK), leptin no longer enhanced the CA secretion evoked by ACh and DMPP. Furthermore, in the presence of anti-leptin (10 ng/ml), an antagonist of Ob receptor, leptin (10 ng/ml) also no longer potentiated the CA secretory responses evoked by DMPP and Bay-K-8644. Collectively, these... -
Curcumin Attenuates Glial Cell Activation But Cannot Suppress Hippocampal CA3 Neuronal Cell Death in i.c.v. Kanic Acid Injection Model
JaeyoungCho, Pil-JaeKong, WanjooChun, Yeo-OkMoon, Yee-TaePark, So-YoungLim, Sung-SooKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 3 307-310 (4 pages)
Kainic acid (KA) is a structural analogue of glutamate that interacts with specific presynaptic and postsynaptic receptors to potentiate the release and excitatory actions of glutamate. Systemic or intracerebroventricular (i.c.v.) administration of KA to experimental animals elicits multifocal seizures with a predominantly limbic localization, and results in neuronal death of cornu ammonia 1 (CA1), reactive gliosis and biochemical changes in the hippocampus and other limbic structures. Several... -
Roles of Gonadal Steroids on Exocrine Secretion of Isolated Perfused Rat Pancreas
HyungSeoPark, SeHoonKim, HyoungJinPark, MeeYoungLee, YoungHeeHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 5 217-221 (5 pages)
effect of secretin. Estradiol-17β failed to change the secretin-induced fluid and amylase secretion. Both progesterone and estradiol-17β did not exert any influence on CCK-induced fluid and amylase secretion. Acetylcholine-induced exocrine secretion of isolated perfused pancreas also was not affected by intra-arterial infusion of progesterone or estradiol-17β. It is concluded from the above results that progesterone could enhance the spontaneous pancreatic fluid and amylase secretion of... -
Influence of Tacrine on Catecholamine Secretion in the Perfused Rat Adrenal Gland
Seok-JeongJang, Won-HoYang, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 6 207-214 (8 pages)
by cyclopiazonic acid (an inhibitor of cytoplasmic Ca2-ATPase, 104 M), was relatively time-dependently attenuated. Also, physostigmine (104 M), given into the adrenal gland for 60 min, depressed CA secretory responses evoked by ACh, McN-A-343 and DMPP while did not affect that evoked by high K. Collectively, these results obtained from the present study demonstrate that tacrine greatly inhibits CA secretion from the perfused rat adrenal gland evoked by stimulation of...
