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Antiapoptotic Effect of Paricalcitol in Gentamicin-induced Kidney Injury
SangHeonSuh, KoEunLee, JeongWooPark, InJinKim, OkKim, ChangSeongKim, JoonSeokChoi, EunHuiBae, SeongKwonMa, JongUnLee, SooWanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 9 435-440 (6 pages)
While the anti-apoptotic effect of paricalcitol has been demonstrated in various animal models, it is not yet clear whether paricalcitol attenuates the apoptosis in gentamicin (GM)-induced kidney injury. We investigated the effect of paricalcitol on apoptotic pathways in rat kidneys damaged by GM. Rats were randomly divided into three groups: 1) Control group (n=8), where only vehicle was delivered, 2) GM group (n=10), where rats were treated with GM (150 mg/kg/day) for 7 days, 3) PARI group... -
A Review on Renal Toxicity Profile of Common Abusive Drugs
VarunParkashSingh, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 13 347-357 (11 pages)
of these drugs are very common. Morphine, heroin, cocaine, nicotine and alcohol are the most commonly abused drugs, and their use is associated with various types of renal toxicity. The renal complications include a wide range of glomerular, interstitial and vascular diseases leading to acute or chronic renal failure. The present review discusses the renal toxicity profile and possible mechanisms of commonly abused drugs including morphine, heroin, cocaine, nicotine, caffeine and alcohol. -
Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
RaviKant, AnjanaBali, NirmalSingh, AmteshwarSinghJaggi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 1 111-120 (10 pages)
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the... -
Cigarette Smoke Extract-induced Reduction in Migration and Contraction in Normal Human Bronchial Smooth Muscle Cells
ChulHoYoon, Hye-JinPark, Young-WooCho, Eun-JinKim, JongDeogLee, KeeRyeonKang, JaeheeHan, DawonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 11 397-404 (8 pages)
as asthma, chronic obstruction pulmonary disease, and cancer. These events can be modulated by a number of factors, including cigarette smoke extract (CSE). CSE-induced alterations in the viability, migration, and contractile abilities of normal human airway cells remain unclear. This study investigated the effect of CSE on cell viability, migration, tumor necrosis factor (TNF)-Ձ secretion, and contraction in normal human bronchial smooth muscle cells (HBSMCs). Treatment of HBSMCs with 10%... -
Effects of Pharmacological Modulators of Ca2+-activated K+ Channels on Proliferation of Human Dermal Fibroblast
JihyunYun, TaehoKim, SoonchulMyung, HyoweonBang, InjaLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 6 95-100 (6 pages)
Employing electrophysiological and cell proliferation assay techniques, we studied the effects of Ca2- activated K channel modulators on the proliferation of human dermal fibroblasts, which is important in wound healing. Macroscopic voltage-dependent outward K currents were found at about 40 mV stepped from a holding potential of 70 mV. The amplitude of K current was increased by NS1619, a specific large-conductance Ca2-activated K (BK)... -
Molecular Mechanism of Pancreatic Bicarbonate Secretion
MinGooLee, JeWooKim, KyungHwanKim, ShmuelMuallem 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.3 1 131-138 (8 pages)
Thanks to recent progress in availability of molecular and functional techniques it became possible to search for the basic molecular and cellular processes that mediate and control HCO3 and fluid secretion by the pancreatic duct. The coordinated action of various transporters on the luminal and basolateral membranes of polarized epithelial cells mediates the transepithelial HCO3 transport, which involves HCO3 absorption in the resting state and HCO3 secretion in the... -
Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia
Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Kim, Seok Woo Moon, Jae Young 대한신경정신의학회 Psychiatry Investigation 8 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 4 767-774 (8 pages)
Objective_Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from the Korean Health Industry Development Institute to investigate the epidemiology, biopsychosocial risk factors, and outcomes of dementia and dementia-related conditions. Methods_The KLOSCAD is the first nationwide multi-center population-based prospective cohort study.... -
폐 기능 검사에 의뢰된 환자에서의 공황발작의 빈도와 특성
정건, 고정선 대한신경정신의학회 신경정신의학 7 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 6호 16 1167-1173 (7 pages)
연구목적: 저자들은 폐 기능 검사에 의뢰된 내과 환자들에서 공황발작의 빈도를 알아보고 공황발작과 불안의 민감도 그리고 폐 기능과의 연관성을 알아보려 하였다. 방 법: 종합병원에서 폐 기능 검사에 의뢰된 대상자들에게 공황발작 설문지와 Beck의 불안검사, 그리고 특성불안 검사의 설문지를 작성케 하였다. 결 과: 55명의 폐 기능 검사를 받은 대상자중 16명(29.1%)이 공황발작을 경험하였다. 공황발작을 경험한 집단 이 경험하지 못한 집단보다 Beck의 불안검사 점수와 특성 불안검사 점수가 모두 의미 있게 높았다. 폐 기능... -
혈액투석요법 환자의 우울, 불안 및 수면장애에 대한 연구
윤석준, 양창국, 한홍무 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1999, 제 38권 제 5호 7 997-1005 (9 pages)
연구목적: 혈액투석요법을 받는 말기 신부전증 환자들은 불안이나 우울 등의 심인증상 외에도 여러가지 수면장애를 호 소할 수 있다. 말기 신부전증 환자에서 심인증상과 수면장애가 많을수록 삶의 질에 장애를 초래하며 혈액투석요 법 도중 탈락이 높다. 저자는 본 연구에서 혈액투석요법 중인 환자의 우울, 불안 및 수면장애 등을 조사하여 향후 환자가료에 활용하고자 하였다. 방 법: 부산시내 4곳의 혈액투석요법기관에서 혈액투석요법을 받는 말기 신부전증 환자 153명(남 87, 여 66)과 정 신적, 신체적으로 건강한 동아대학교병원...


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