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Proteomic Analysis of Differentially Expressed Proteins in Bovine Endometrium with Endometritis
ChangyongChoe, Jeong-WonPark, Eun-SukKim, Sung-GyuLee, Sun-YoungPark, Jeong-SoonLee, Myung-JeCho, KeeRyeonKang, JaeheeHan, DawonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.4 2 205-212 (8 pages)
Endometritis is one of the primary reasons for reproductive failure. In order to investigate endometritis-associated marker proteins, proteomic analysis was performed on bovine endometrium with endometritis. In bovine endometritis, desmin, Ձ-actin-2, heat-shock protein (HSP) 27, peroxiredoxin-6, luteinizing hormone receptor isoform 1, collectin-43 precursor, deoxyribonuclease-I (DNase-I), and MHC class I heavy chain (MHC-Ih) were up-regulated. In contrast, transferrin, interleukin-2... -
Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice
HyunJeongKim, Ji-InJung, YoungkyungKim, Jae-SeonLee, YoungWookYoon, JunesunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 7 157-161 (5 pages)
Heat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in hsp70.1 knockout (KO) mice and their wild-type (WT) mice via the Basso, Beattie and Bresnahan (BBB)... -
Pyrithione-zinc Prevents UVB-induced Epidermal Hyperplasia by Inducing HIF-1α
Young-SukCho, Kyung-HoonLee, Jong-WanPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 5 91-97 (7 pages)
Epidermal keratinocytes overgrow in response to ultraviolet-B (UVB), which may be associated with skin photoaging and cancer development. Recently, we found that HIF-1Ձ controls the keratinocyte cell cycle and thereby contributes to epidermal homeostasis. A further study demonstrated that HIF-1Ձ is down-regulated by UVB and that this process is involved in UVB-induced skin hyperplasia. Therefore, we hypothesized that the forced expression of HIF-1Ձ in keratinocytes would... -
Roles of ERK and NF-κB in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells
Seung-HunKang, Ji-HyukLee, Kyung-HaChoi, Byung-YongRhim, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 7 171-176 (6 pages)
Heat shock proteins (HSPs) serve as molecular chaperones and play a role in cell protection from damage in response to stress stimuli. The aim of this article is to investigate whether HSP22 affects IL-8 expression in vascular smooth muscle cells (VSMCs), and which cellular factors are involved in the HSP-mediated IL-8 induction in that cell type in terms of mitogen activated protein kinase (MAPK) and transcription element. Exposure of aortic smooth muscle cells (AoSMCs) to HSP22 not only... -
정신분열병 환자에서 항정신병약 투여에 의한 Heat Shock Protein 70 및 90항체의 변화
김재현, 이수정 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 2001, 제 40권 제 1호 15 142-150 (9 pages)
환자군에서의 HSP70 항체 발현을 감소시켰으나, HSP90 항 체에 대해서는 영향이 없었다. 한편, 정신분열병의 임상양상 중에서는 증상의 심각도(BPRS)만이 약물치료 전 환자군에서의 HSP70 항체의 발현과 유의한 관련이 있었다. 결 론： 정신분열병환자에서의 HSP 항체 증가와 항정신병약에 의한 HSP 항체 발현 감소를 보여준 본 연구의 결 과는, HSP 또는 HSP항체가 정신분열병의 병태생리와 관련되어 있을 가능성을 제시하는 것이다. 또한 정신 분열병에서의 HSP70 및 HSP90 항체의 차별적인 발현양상은 정신분열병에서의 HSP의 역할이... -
정신분열병과 Heat Shock Protein 70 유전자 다형성과의 관련
김정진, 이경욱, 이수정, 권오주, 이창욱, 이철, 백인호, 한진희 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 2002, 제 41권 제 5호 9 814-822 (9 pages)
연구목적： 정신분열병의 발병 원인은 아직 명확히 밝혀져 있지 않으나, 유전적, 환경적, 내분비적 병인 등이 보고되어 왔다. 이 중에는 태아의 발육과정에서 임신 중반기의 산모의 감염, 자가 면역 질환 등 여러 가지 병적 자극들이 정상적인 신경계 발달에 장애를 가져오고 정신분열병을 일으킨다는 신경 발달 가 설이 포함되는데, 최근 이 가설을 지지하는 연구결과들이 증가하고 있다. Heat shock protein(HSP) 은 세포를 보호하는 분자 보호자로서의 역할을 하는 것으로 알려져 있는데, 특히 HSP70에 대한 항체 가 정신분열병... -
A Histone Deacetylase, MoHDA1 Regulates Asexual Development and Virulence in the Rice Blast Fungus
Taehyun Kim, Song Hee Lee, Young Taek Oh, Junhyun Jeon 한국식물병리학회 The Plant Pathology Journal 9 Pages
한국식물병리학회 The Plant Pathology Journal 2020, 36권 4호 2 314-322 (9 pages)
Interplay between histone acetylation and deacetylation is one of the key components in epigenetic regulation of transcription. Here we report the requirement of Mo- HDA1-mediated histone deacetylation during asexual development and pathogenesis for the rice blast fungus, Magnaporthe oryzae. Structural similarity and phylogenetic analysis suggested that MoHDA1 is an ortholog of Saccharomyces cerevisiae Hda1, which is a representative member of class II histone deacetylases. Targeted deletion of... -
Transcriptomic Analysis of Oryza sativa Leaves Reveals Key Changes in Response to Magnaporthe oryzae MSP1
Qingfeng Meng, Ravi Gupta, Soon Jae Kwon, Yiming Wang, Ganesh Kumar Agrawal, Randeep Rakwal, Sang-Ryeol Park, Sun Tae Kim 한국식물병리학회 The Plant Pathology Journal 12 Pages
한국식물병리학회 The Plant Pathology Journal 2018, 34권 4호 1 257-268 (12 pages)
Rice blast disease, caused by Magnaporthe oryzae, results in an extensive loss of rice productivity. Previously, we identified a novel M. oryzae secreted protein, termed MSP1 which causes cell death and pathogen-associated molecular pattern (PAMP)-triggered immune (PTI) responses in rice. Here, we report the transcriptome profile of MSP1-induced response in rice, which led to the identification of 21,619 genes, among which 4,386 showed significant changes (P < 0.05 and fold change > 2 or < 1/2)... -
Heat Shock Proteins: A Review of the Molecular Chaperones for Plant Immunity
한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2015, 31권 4호 1 323-333 (11 pages)
As sessile organisms, plants are exposed to persistently changing stresses and have to be able to interpret and respond to them. The stresses, drought, salinity, chemicals, cold and hot temperatures, and various pathogen attacks have interconnected effects on plants, resulting in the disruption of protein homeostasis. Maintenance of proteins in their functional native conformations and preventing aggregation of non-native proteins are important for cell survival under stress. Heat shock proteins... -
Development of a Selective Medium for the Fungal Pathogen Cylindrocarpon destructans Using Radicicol
한국식물병리학회 The Plant Pathology Journal 5 Pages
한국식물병리학회 The Plant Pathology Journal 2014, 30권 4호 11 432-436 (5 pages)
The soil-borne ascomycete fungus Cylindrocarpon destructans causes ginseng root rot disease and produces various secondary metabolites such as brefeldin A and radicicol. The slow growth of this fungus compared with other plant pathogenic and saprophytic fungi in soil disturbs isolation of this fungus from soil and infected ginseng. In this study, we developed a selective medium for C. destructans using radicicol produced by this fungus. Supplementing 50 mg/L of radicicol to medium inhibited the...
