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A 2-week Dose Range Finding Study of KMRC01, Salmonella flagellin-derived TLR 5 agonist, administered by intramuscular injection in Cynomolgus Monkeys
Hong Soo Lee, Son Il Pak, Doo Wan Cho, Woo Jong Lee, Chi Min Choi, Dong Hun Jung, Su Cheol Han 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 180 309-309 (1 pages)
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Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model
Joongsun Kim, Sunhoo Park, Byung-Suk Jeon, Won-Seok Jang, Sun-Joo Lee, Yeonghoon Son, Kyung-Jin Rhim, Soong In Lee, Seung-Sook L 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 4호 1 435-444 (10 pages)
a mini-pig model. Histological and clinical changes were observed five weeks after radiation exposure to the back (Co gamma-radiation, 50 Gy). Curcumin was applied topically to irradiated skin (200 mg/cm) twice a day for 35 days. Curcumin application decreased the epithelial desquamation after irradiation. Additionally, when compared to the vehicle-treated group, the curcumin-treated group showed reduced expression of cyclooxygenase-2 and nuclear factor-kappaB. Furthermore, irradiation prolonged... -
Differential expression of thymic DNA repair genes in low-dose-rate irradiated AKR/J mice
Jin Jong Bong, Yu Mi Kang, Suk Chul Shin, Seung Jin Choi, Kyung Mi Lee, Hee Sun Kim 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 6 271-279 (9 pages)
in a low-dose-rate (LDR) (Cs, 0.7 mGy/h, 2.1 Gy) γ-irradiation facility developed less spontaneous thymic lymphoma and survived longer than those receiving sham or high-dose-rate (HDR) (Cs, 0.8 Gy/min, 4.5 Gy) radiation. Interestingly, histopathological analysis showed a mild lymphomagenesis in the thymus of LDR-irradiated mice. Therefore, in this study, we investigated whether LDR irradiation could trigger the expression of thymic genes involved in the DNA repair process of AKR/J mice. The... -
Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line
Irene Flickinger*, Barbara C Rütgen, Wilhelm Gerner, Ivana Calice, Alexander Tichy, Armin Saalmüller, Miriam Kleiter 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 2호 13 207-214 (8 pages)
in a radiation dose dependent manner. VEGF was secreted constitutively and significant up-regulation was observed in the 8 and 10 Gy irradiated cells. In addition, a minor portion of TLM 1 cells expressed vascular endothelial growth factor receptor (VEGFR)-1 intracellularly. VEGFR-2 was detected in the cytoplasm and was down-regulated following radiation with increasing dosages. In TLM 1 cells, apoptosis plays an important role in radiation induced cell death. It has also been suggested that the... -
Protective effect of the isoflavone equol against DNA damage induced by ultraviolet radiation to hairless mouse skin
Sitarina Widyarini 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 3호 2 217-223 (7 pages)
protect not only against ultraviolet (UV) radiation-induced cutaneous inflammation and photoimmune suppression, but also have antiphotocarcinogenic properties in mice. Because the state of DNA damage has been correlated with suppression of the immune system and photocarcinogenesis, we have therefore examined the potential of equol to offer protection from solar-simulated UV (SSUV) radiation-induced DNA damage in hairless mice by the immunohistochemical approach using monoclonal antibody specific... -
Effect of ultraviolet radiation on the hatchability and survival of eggs and larvae of sheep nematode
Isaiah Oluwafemi Ademola and Janet Ayobami Ademola 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 1호 8 59-62 (4 pages)
gastrointestinal nematode eggs exposed to ultraviolet (UV) radiation and the activity of the hatched larvae were examined. Hatchability decreased with increasing exposure to radiation. The difference in hatchabilityof eggs irradiated for 15,30 and 60 minutes were highly significant (p < 0.01 dα = 3.07, 3.24 and 3.75) compared with the hatchability of the nonirradiated eggs. The life span of irradiated larvae was shortened, only 20% of those expose to UV radiation 60 minutes survive for 2... -
Clinical management of suspected intracranial meningioma in three dogs with pulsed high-dose hydroxyurea
Jae-Geum Cho, Kun-Ho Song, Kyoung-Won Seo 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 4 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2018, 제 58권 제 2호 7 103-106 (4 pages)
Two cases were tentatively diagnosed with intracranial meningioma based on magnetic resonance imaging, and one case was histopathologically confirmed as meningioma at necropsy. All dogs improved after initiation of pulsed high-dose hydroxyurea (HU) treatment. Clinical sign relapses were managed by repeating high-dose HU without obvious side effects. Pulsed high-dose HU can be applied when clinical signs are refractory to the traditionally recommended dosage for intracranial meningioma in dogs. -
Protective effect of the methanol extract of Polyopes Lancifolia (Harvey) kawaguchi et wang against ionizing radiation-induced mouse gastrointestinal injury
Sung Ho Kim , Tae Kyun Shin , Mee Jung Ahn , Jin Woo Jeong , Jin Won Hyun , Chang Jong Moon , Won Jun Yang , Ki Cheon Ki 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2011, 제 51권 제 3호 1 177-183 (7 pages)
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Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial Cells
HeeJin, HyeEunYoon, Jae-SeonLee, Jae-KyungKim, SungHoMyung, Yun-SilLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 6 119-124 (6 pages)
stress factor, such as ionizing radiation (IR) or H2O2, results in genomic instability in non-tumorigenic human lung epithelial L132 cells. To this end, the percentages of G2/M-arrested cells and aneuploid cells were examined. Exposure to 0.5 Gy IR or 0.05 mM H2O2 for 9 h resulted in the highest levels of aneuploidy; however, no cells were observed in the subG1 phase, which indicated the absence of apoptotic cell death. Exposure to an ELF-MF alone (1 mT or 2 mT) did not affect the percentages of... -
Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells
YunTaiKim, SooShinJo, YoungJunPark, MyungZaLee, ChangKookSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 10 509-516 (8 pages)
Radiation therapy for variety of human solid tumors utilizes mechanism of cell death after DNA damage caused by radiation. In response to DNA damage, cytochrome c was released from mitochondria by activation of pro-apoptotic Bcl-2 family proteins, and then elicits massive Ca2+ release from the ER that lead to cell death. It was also suggested that irradiation may cause the deregulation of Ca2+ homeostasis and trigger programmed cell death and regulate death specific enzymes. Thus, in this...


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