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Renal Handling of Sodium and Potassium in Cadmium Exposed Rats
YungKyuKimYangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 12 503-510 (8 pages)
Effects of cadmium exposure on renal Na and K transports were studied in rats. During the course of cadmium treatment (2 mg Cd/kg/day, s.c. injections for 3 weeks) renal tubular transports of Na and K were evaluated by lithium clearance technique. During the early phase (first week) of cadmium treatment, urinary Na excretion decreased drastically and this was due to an increased Na reabsorption both in the proximal and distal nephrons. During the late... -
Interaction of 17β-Estradiol with EGF and IGF-I on Proliferation and Pi Uptake in Primary Cultured Rabbit Renal Proximal Tubular Cells
HoJaeHanYeunHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 11 493-501 (9 pages)
causes the neoplastic transformation of renal cortical cells is yet to be uncovered. The present study was designed to evaluate interaction of 17-estradiol (E2) with epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) on proliferation and Pi uptake in primary cultured rabbit renal proximal tubular cells in phenol red-free, hormonally defined-medium. [3H]-thymidine incorporation increased markedly by about 133% and 141% more in the presence of 109 and 106... -
Altered Renal Nitric Oxide System in Experimental Hypertensive Rats
EunSukYang, JongUnLee, DaeGillKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 7 455-460 (6 pages)
expression of both bNOS and ecNOS was decreased, along with tissue contents of nitrites. In 2K1C hypertension, the nitrite content of the clipped kidney was decreased along with ecNOS levels, whereas neither the nitrite content nor the expression of NOS isoforms was significantly altered in the contralateral non-clipped kidney. These results suggest that the development of hypertension is associated with an altered renal expression of NOS and nitric oxide generation in DOCA-salt and 2K1C rats. -
Changes of Renal Peripheral Benzodiazepine Receptor in the Stress/ Anxiety Response
Jeoung-HeeHa, Kwang-HunLee, Seung-DoukCheung, Hyung-BaePark, Maan-GeeLee, Hyoung-ChulChoi, Uy-DongSohn, Kwang-YounLee, Won-JoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 7 523-528 (6 pages)
analysis of the results showed that the increase in the density of PBR and the affinity of the PBR remained unchanged. Forced swim stress increased anxiety on the plus maze in both groups of rats. In contrast to control, diazepam progenies did not show further upregulation of renal PBR immediately after swimming stress, but still higher than control. From the above results, it may be concluded that upregulation of renal PBR is associated with chronic anxiety as well as stress-induced response. -
Regulatory Mechanisms of Angiotensin II on the Na+/H+ Antiport System in Rabbit Renal Proximal Tubule Cells. II. Inhibitory Effects of ANG II on Na+ Uptake
HoJaeHan, SooHyunPark, HyunJuKoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 9 425-434 (10 pages)
of primary cultured rabbit renal proximal tubule cells(PTCs) in hormonally defined serum-free medium. High concentrations of ANG II (>10-9 M) inhibited Na+ uptake and increased [Ca2+]i level in the PTCs. However, low concentrations of (<10-11 ANG II) stimulated Na+ uptake and did not affect [Ca2+]i level. 8-(N, N-diethylamino)-octyl-3,3,5- trimethoxybenzoate (TMB-8), ethylene glycol-bis(β-amino ethyl ether)-N,N,N', N'-tetra acetic acid (EGTA), and nifedifine partially blocked the inhibitory... -
Regulatory Mechanisms of Angiotensin II on the Na+/H+ Antiport System in Rabbit Renal Proximal Tubule Cells. I. Stimulatory Effects of ANG II on Na+ Uptake
HoJaeHan, HyunJuKoh, SooHyunPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 8 413-423 (11 pages)
a major role in the development of hypertension. Among these factors angiotensin II (ANG II) is closely involved in renal hypertension development since it directly regulates Na+ reabsorption in the renal proximal tubule. Thus the aim of the present study was to examine signaling pathways of low dose of ANG II on the Na+ uptake of primary cultured rabbit renal proximal tubule cells (PTCs) in hormonally defined serum-free medium. The results were as follows: 1) 10-11 M ANG II has a significant... -
Changes in Renal Brush-Border Sodium-Dependent Transport Systems in Gentamicin-Treated Rats
SoongYongSuhl, DoWhanAhn, KyoungRyongKim, JeeYeunKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 7 403-411 (9 pages)
To elucidate the mechanism of gentamicin induced renal dysfunction, renal functions and activities of various proximal tubular transport systems were studied in gentamicin-treated rats (Fisher 344). Gentamicin nephrotoxicity was induced by injecting gentamicin sulfate subcutaneously at a dose of 100 mg/kg·day for 7 days. The gentamicin injection resulted in a marked polyuria, hyposthenuria, proteinuria, glycosuria, aminoaciduria, phosphaturia, natriuresis, and kaliuresis, characteristics of... -
Adenosine 수용체 작동제 장기 투여의 신장효과 Renal Effects of Chronic Treatment of Adenosine Analogues
김택희, 김선희, 허종, 조경우, TackHeeKim, SuhnHeeKim, JongHuh, KyungWooCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.3 11 325-335 (11 pages)
osmolarity and free water reabsorption. This phenomenon was reversible and repeatable. Administration of adenosine (40 mg/kg/day) produced no apparent effect on the renal function, whereas PIA (2 mg/kg/day) produced an similar effect to CHA on the renal function. Systemic adminstration of NECA, 0.025, 0.05 and 0.25 mg/kg/day, for 3 days caused a dose-dependent increase in urine volume and dose-dependent increases in excreted amount of creatinine, urinary osmolarity and free water reabsorption....


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