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521.

Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene K+ Channels

JihyunYun, HyemiBae, SunEunChoi, Jung-HaKim, YoungWookChoi6, InjaLim, ChungSooLee, MinWonLee, Jae-HongKo, SeongJunSeo, HyoweonBang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 6 37-42 (6 pages)

JihyunYun, HyemiBae, SunEunChoi, Jung-HaKim, YoungWookChoi6, InjaLim, ChungSooLee, MinWonLee, Jae-HongKo, SeongJunSeo, HyoweonBang 저
...
- 3,000원
a whole-cell patch clamp technique. We found that taxifolin glycoside directly blocked hERG K+ current in a concentration-dependent manner (EC50=9.6±0.7ՌM). The activation curve of hERG K+ channels was negatively shifted by taxifolin glycoside. In addition, taxifolin glycoside accelerated the activation time constant and reduced the onset of the inactivation time constant. These results suggest that taxifolin glycoside blocks hERG K+ channels that function by facilitating activation and...
522.

Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse

Soo-HyunPark, Yun-BeomSim, Yu-JungKang, Jin-KooLee, Soon-SungLim, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 6 119-123 (5 pages)

Soo-HyunPark, Yun-BeomSim, Yu-JungKang, Jin-KooLee, Soon-SungLim, Hong-WonSuh 저
...
- 1,500원
In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Agrimonia pilosa Ledeb extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 Ռg) was...
523.

The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats

Hyun-JungPark, HyunSooShim, KyungSooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 3 333-338 (6 pages)

Hyun-JungPark, HyunSooShim, KyungSooKim, InsopShim 저
...
- 3,000원
Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the...
524.

Inhibitory Actions of HERG Currents by the Immunosuppressant Drug Cyclosporin A

SeungHoLee, SangJuneHahn, GyesikMin, JimokKim, Su-HyunJo, HanChoe, BokHeeChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 7 291-298 (8 pages)

SeungHoLee, SangJuneHahn, GyesikMin, JimokKim, Su-HyunJo, HanChoe, BokHeeChoi 저
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- 3,000원
The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique. CsA inhibited the HERG channel in a concentration-dependent manner, with an IC50 value and a Hill coefficient of 3.17ՌM and 0.89, respectively. Pretreatment with cypermethrine, a calcineurin inhibitor, had no effect on the CsA-induced inhibition of the HERG channel. The...
525.

Antinociception Effect and Mechanisms of Campanula Punctata Extract in the Mouse

Soo-HyunPark, Yun-BeomSim, Soon-SungLim, Jin-KyuKim, Jin-KooLee, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 6 285-289 (5 pages)

Soo-HyunPark, Yun-BeomSim, Soon-SungLim, Jin-KyuKim, Jin-KooLee, Hong-WonSuh 저
...
- 1,500원
In the present study, the antinociceptive profiles of Campanula punctata extract were examined in ICR mice. The Campanula punctata contain a large dose of saponin. Campanula punctata extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Campanula punctata extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.)...
526.

A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K＋ Channels in Rabbit Ventricular Myocytes

WonSunPark, YounKyoungSon, EunAKo, SeongWooChoi, NariKim, Tae-HoonChoi, HyunJooYoun, Su-HyunJo, DaHyeHong, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 1 119-125 (7 pages)

WonSunPark, YounKyoungSon, EunAKo, SeongWooChoi, NariKim, Tae-HoonChoi, HyunJooYoun, Su-HyunJo, DaHyeHong, JinHan 저
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- 3,000원
We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K＋ current (IK) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC50 value of 56.1±5.5Ռg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating IK without significantly altering the resting membrane...
527.

Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca2＋ Channels in Neonatal Rat Ventricular Cardiomyocytes

OlegV.Yarishkin, EunMiHwang, DonggyuKim, JaeChealYoo, SangSooKang, DeokRyoungKim, Jae-Hee-JungShin, Hye-JooChung, Ho-SangJeong, DawonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 5 437-442 (6 pages)

OlegV.Yarishkin, EunMiHwang, DonggyuKim, JaeChealYoo, SangSooKang, DeokRyoungKim, Jae-Hee-JungShin, Hye-JooChung, Ho-SangJeong, DawonKang 저
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- 3,000원
the L-type calcium channels which are essential to the E-C coupling at the level of single ventricular myocytes isolated from neonatal rat heart, using the whole-cell voltage-clamp technique. Only diclofenac of three NSAIDs, including naproxen and ibuprofen, significantly reduced inward whole cell currents. At concentrations higher than 3ՌM, diclofenac inhibited reversibly the Na＋ current and did irreversibly the L-type Ca2＋ channels-mediated inward current (IC50=12.89±0.43ՌM) in...
528.

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

TaeKyeongShin, MiSunKang, HoYounLee, MooSangSeo, SiGeunKim, ChiDaeKim, WonSukLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 17 257-263 (7 pages)

TaeKyeongShin, MiSunKang, HoYounLee, MooSangSeo, SiGeunKim, ChiDaeKim, WonSukLee 저
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- 3,000원
This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic...
529.

Testosterone Relaxes Rabbit Seminal Vesicle by Calcium Channel Inhibition

JongKokKim, WooHaHan, MooYeolLee, SoonChulMyung, SaeChulKim, MinKyKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.2 6 73-78 (6 pages)

JongKokKim, WooHaHan, MooYeolLee, SoonChulMyung, SaeChulKim, MinKyKim 저
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- 3,000원
in a rabbit model. The contractile responses of circular smooth muscle strips of rabbit seminal vesicles to norepinephrine (10ՌM), a high concentration of KCl (70 mM), and testosterone (10ՌM) were observed. Single vesicular myocytes of rabbit were isolated using proteolytic enzymes including collagenase and papain. Inside-out, attached, and whole-cell configurations were examined using the patch clamp technique. The applications of 10ՌM norepinephrine or 70 mM KCl induced tonic...
530.

Expression of Ca2+-activated K+ Channels and Their Role in Proliferation of Rat Cardiac Fibroblasts

SeyongChoi, WooseokLee, JihyunYun, JeongseokSeo, InjaLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.2 3 51-58 (8 pages)

SeyongChoi, WooseokLee, JihyunYun, JeongseokSeo, InjaLim 저
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- 3,000원
small conductance KCa (SK1∼4 subunits) channels. Thirdly, we recorded BK, IK, and SK channels by whole cell mode patch clamp technique using their specific blockers. Finally, we performed cell proliferation assay to evaluate the effects of the channels on cell proliferation, and found that the inhibition of IK channel increased the cell proliferation. These results showed the existence of BK, IK, and SK channels in rat ventricular fibroblasts and involvement of IK channel in cell proliferation.

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