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521.

GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition

HwaOkLee, YuJeongByun, Kyung-OkCho, SeongYunKim, Seong-BeomLee, Ho-ShikKim, Oh-JooKwon, Seong-WhanJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 5 149-156 (8 pages)

HwaOkLee, YuJeongByun, Kyung-OkCho, SeongYunKim, Seong-BeomLee, Ho-ShikKim, Oh-JooKwon, Seong-WhanJeong 저
...
- 3,000원
Golgi SNAP receptor complex 1 (GS28) has been implicated in vesicular transport between intra-Golgi networks and between endoplasmic reticulum (ER) and Golgi. Additional role(s) of GS28 within cells have not been well characterized. We observed decreased expression of GS28 in rat ischemic hippocampus. In this study, we examined the role of GS28 and its molecular mechanisms in neuronal (SK-N-SH) cell death induced by hydrogen peroxide (H2O2). GS28 siRNA-transfected cells treated with H2O2 showed...
522.

5-Hydroxytryptamine Generates Tonic Inward Currents on Pacemaker Activity of Interstitial Cells of Cajal from Mouse Small Intestine

PawanKumarShahi, SeokChoi, DongChuanZuo, CheolHoYeum, PyungJinYoon, JunLee, YoungDaeKim, ChanGukPark, ManYooKim, HyeRangShin, HyunJungOh, J 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 2 129-135 (7 pages)

PawanKumarShahi, SeokChoi, DongChuanZuo, CheolHoYeum, PyungJinYoon, JunLee, YoungDaeKim, ChanGukPark, ManYooKim, HyeRangShin, HyunJungOh, J 저
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- 3,000원
In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions of 5-HT on pacemaker activities were investigated using a whole-cell patch-clamp technique, intracellular Ca2＋ ([Ca2＋]i) analysis, and RT-PCR in ICC. Exogenously-treated 5-HT showed tonic inward currents on pacemaker currents in ICC under the voltage-clamp mode in a dose-dependent manner. Based on RT-PCR...
523.

Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase

WoosungShin, ToDaoCuong, JeongHyungLee, ByungsunMin, ByeongHwaJeon, HyunKyoLim, SungwooRyoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 1 123-128 (6 pages)

WoosungShin, ToDaoCuong, JeongHyungLee, ByungsunMin, ByeongHwaJeon, HyunKyoLim, SungwooRyoo 저
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- 3,000원
Caesalpinia sappan (C. sappan) is a medicinal plant used for promoting blood circulation and removing stasis. During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of C. sappan (CLE) showed inhibitory activity on arginase which has recently been reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. CLE inhibited arginase II activity prepared from kidney lysate in a dose-dependent manner. In HUVECs,...
524.

Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

Song-InKim, Won-KiLee, Sang-SooKang, Sue-YoungLee, Myeong-JaJeong, HeeJaeLee, Sung-SooKim, GallV.W.Johnson, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 6 107-114 (8 pages)

Song-InKim, Won-KiLee, Sang-SooKang, Sue-YoungLee, Myeong-JaJeong, HeeJaeLee, Sung-SooKim, GallV.W.Johnson, WanjooChun 저
...
- 3,000원
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3Ղ has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate the aggregate formation of tau. The present study examined the role of GSK3Ղ-mediated phosphorylation of tau species on their autophagic degradation. We transfected wild type tau (T4), caspase-3-cleaved tau at Asp421 (T4C3), or pseudophosphorylated tau at Ser396/Ser404 (T4-2EC) in the...
525.

Characterization and Immunopotentiating Effects of the Glycoprotein Isolated from Dioscorea Batatas

PhamThiThuHuong, Chan-HoLee, MeiHongLi, MinYoungLee, Joon-KiKim, Sun-MeeLee, Jong-HeumSeon, Dong-CheolLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 5 101-106 (6 pages)

PhamThiThuHuong, Chan-HoLee, MeiHongLi, MinYoungLee, Joon-KiKim, Sun-MeeLee, Jong-HeumSeon, Dong-CheolLee, YoungJinJeon 저
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- 3,000원
We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages, lymphocytes, neutrophils, and monocytes into the peritoneal cavity. Treatment of spleen cells isolated from C57BL/6 mice with GDB significantly increased the proliferation of B cells and T cells induced by LPS and ConA,...
526.

Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring

JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 1 67-82 (16 pages)

JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 저
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- 4,500원
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the...
527.

Inhibitory Effects of Corni Fructus Extract on Angiogenesis and Adipogenesis

Jae-HoHwang, Jong-DeogKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 7 43-52 (10 pages)

Jae-HoHwang, Jong-DeogKim 저
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- 3,000원
Natural products in Chonnam, Korea were screened via anti-angiogenesis experiments, and 1 candidate product was identified, Corni fructus, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. C. fructus extract (CFE) exhibits an angiogenesis inhibi</I>tory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and adipogenesis-related signal molecules in the western blotting was reduced by increasing...
528.

Microarray Analysis of Gene Expression Profiles in Response to Treatment with Melatonin in Lipopolysaccharide Activated RAW 264.7 Cells

JuYeonBan, BumSikKim, SooCheolKim, DongHwanKim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 4 23-30 (8 pages)

JuYeonBan, BumSikKim, SooCheolKim, DongHwanKim, Joo-HoChung 저
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- 3,000원
Melatonin, which is the main product of the pineal gland, has well documented antioxidant and immune-modulatory effects. Macrophages produce molecules that are known to play roles in inflammatory responses. We conducted microarray analysis to evaluate the global gene expression profiles in response to treatment with melatonin in lipopolysaccharide (LPS) activated RAW 264.7 macrophage cells. In addition, eight genes were subjected to real-time reverse transcription polymerase chain reaction...
529.

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated from Rhus verniciflua in LPS-stimulated BV2 Microglial Cells

Jae-WonLee, Il-YoungCheong, Hae-SungKim, JaeJunLee, Yong-SukLee, Yong-SooKwon, Myong-JoKim, HeeJaeLee, Sung-SooKim, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 2 9-16 (8 pages)

Jae-WonLee, Il-YoungCheong, Hae-SungKim, JaeJunLee, Yong-SukLee, Yong-SooKwon, Myong-JoKim, HeeJaeLee, Sung-SooKim, WanjooChun 저
...
- 3,000원
Although various derivatives of caffeic acid have been reported to possess a wide variety of biological activities such as protection of neuronal cells against excitotoxicity, the biological activity of 1-docosanoyl cafferate (DC) has not been examined. The objective of the present study was to evaluate the anti-inflammatory effects of DC, isolated from the stem bark of Rhus verniciflua, on lipopoly</I>saccharide (LPS)-stimulated BV2 microglial cells. Pretreatment of cells with DC...
530.

Involvement of ROS in Curcumin-induced Autophagic Cell Death

YounJuLee, Nam-YiKim, Young-AhSuh, ChuHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.1 1 1-8 (8 pages)

YounJuLee, Nam-YiKim, Young-AhSuh, ChuHeeLee 저
...
- 3,000원
Many anticancer agents as well as ionizing radiation have been shown to induce autophagy which is originally described as a protein recycling process and recently reported to play a crucial role in various disorders. In HCT116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and degradation of sequestome-1 (SQSTM1) which is a...

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