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561.

Intestinal Absorption of Fibrinolytic and Proteolytic Lumbrokinase Extracted from Earthworm, Eisenia andrei

XiangMeiYan, Chung-HyoKim, ChulKyuLee, JangSikShin, IlHwanCho, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 2 71-75 (5 pages)

XiangMeiYan, Chung-HyoKim, ChulKyuLee, JangSikShin, IlHwanCho, UyDongSohn 저
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- 1,500원
method. We extracted lumbrokinase from Eisenia andrei, and then raised polyclonal antibody against lumbrokinase. Fibrinolytic activity and proteolytic activity in the serosal side of rat everted gut sacs incubated with lumbrokinase showed dose- and time-dependent patterns. Immunological results obtained by western blotting serosal side solution using rat everted gut sacs method showed that lumbrokinase proteins between 33.6 and 54.7 kDa are absorbed mostly by the intestinal epithelium....
562.

Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-κB DNA-binding Activity in RAW 264.7 Cells

SeongKeunKim, YoungMiKim, ChungEunYeum, Song-HyoJin, GueTaeChae, Seong-BeomLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 11 475-482 (8 pages)

SeongKeunKim, YoungMiKim, ChungEunYeum, Song-HyoJin, GueTaeChae, Seong-BeomLee 저
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- 3,000원
Rifampicin is a macrocyclic antibiotic which is used extensively for treatment against Mycobacterium tuberculosis and other mycobacterial infections. Recently, a number of studies have focused on the immune-regulatory effects of rifampicin. Therefore, we hypothesized that rifampicin may influence the TLR2 expression in LPS-activated RAW 264.7 cells. In this study, we determined that rifampicin suppresses LPS-induced TLR2 mRNA expression. The down-regulation of TLR2 expression coincided with...
563.

The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats

YoungBaeKwon, YoungChanJeong, JungKeeKwon, JiSeonSon, KeeWonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 3 425-429 (5 pages)

YoungBaeKwon, YoungChanJeong, JungKeeKwon, JiSeonSon, KeeWonKim 저
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- 1,500원
which was significantly attenuated by BD1047 pretreatment. BD1047 consistently reduced capsaicin-induced Fos-like immunoreactivity (Fos-LI), a neuronal activator, in the TNC in a dose-dependent manner. Moreover, capsaicin- induced phosphorylation of N-methyl-D-aspartate receptor subunit 1 was reversed by BD1047 pretreatment in the TNC. These results indicate that the Sig-1R antagonist has an inhibitory effect on nociceptive activation of the TNC in the capsaicin-induced headache animal model.
564.

Altered Gene Expression in Cerulein-Stimulated Pancreatic Acinar Cells: Pathologic Mechanism of Acute Pancreatitis

JiHoonYu, JooWeonLim, HyeyoungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 1 409-416 (8 pages)

JiHoonYu, JooWeonLim, HyeyoungKim 저
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- 3,000원
Acute pancreatitis is a multifactorial disease associated with the premature activation of digestive enzymes. The genes expressed in pancreatic acinar cells determine the severity of the disease. The present study determined the differentially expressed genes in pancreatic acinar cells treated with cerulein as an in vitro model of acute pancreatitis. Pancreatic acinar AR42J cells were stimulated with 10−8 M cerulein for 4 h, and genes with altered expression were identified using a cDNA...
565.

Arachidonic Acid Activates K＋-Cl?-cotransport in HepG2 Human Hepatoblastoma Cells

YongSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 11 401-408 (8 pages)

YongSooLee 저
...
- 3,000원
in a dose-dependent manner, which was completely blocked by R-(＋)-[2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H- inden-5-yl]oxy]acetic acid (DIOA), a specific KCC inhibitor. N-Ethylmaleimide (NEM), a KCC activator- induced K＋ efflux was significantly suppressed by bromoenol lactone (BEL), an inhibitor of the calcium- independent PLA2 (iPLA2), whereas it was not significantly altered by arachidonyl trifluoromethylketone (AACOCF3) and p-bromophenacyl bromide (BPB), inhibitors of the...
566.

Preventing Extracellular Diffusion of Trigeminal Nitric Oxide Enhances Formalin-induced Orofacial Pain

Hwi-SeokJung, Hong-BinJeon, Ik-SungJeon, Bum-JunLee, Hyun-WooYoo, Dong-KukAhn, Dong-HoYoun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 8 379-383 (5 pages)

Hwi-SeokJung, Hong-BinJeon, Ik-SungJeon, Bum-JunLee, Hyun-WooYoo, Dong-KukAhn, Dong-HoYoun 저
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- 1,500원
Nitric oxide (NO), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information from periphery. In the spinal cord, it has been demonstrated that NO acts as pronociceptive or antinociceptive mediators, apparently in a concentration-dependent manner. However, the central role of NO in the trigeminal nucleus remains uncertain in support of processing the orofacial...
567.

Effects of Losartan on Catecholamine Release in the Isolated Rat Adrenal Gland

Hae-JeongNoh, Yoon-SungKang, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 10 327-335 (9 pages)

Hae-JeongNoh, Yoon-SungKang, Dong-YoonLim 저
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- 3,000원
90 min produced dose- and time-dependent inhibition of the CA secretory responses evoked by ACh (5.32 mM), high K＋ (56 mM, a direct membrane depolarizer), DMPP (100ՌM) and McN-A-343 (100ՌM). Losartan failed to affect basal CA output. Furthermore, in adrenal glands loaded with losartan (15 ՌM) for 90 min, the CA secretory responses evoked by Bay-K-8644 (10ՌM, an activator of L-type Ca2＋ channels), cyclopiazonic acid (10ՌM, an inhibitor of cytoplasmic Ca2＋-ATPase),...
568.

DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-κB Activity in LPS-treated Human Umbilical Vein Endothelial Cells

SoonAeLee, HyeJungKim, KiChurlChang, JongChulBaek, JiKwonPark, JeongKyuShin, WonJunChoi, JongHakLee, WonYoungPaik 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 6 301-307 (7 pages)

SoonAeLee, HyeJungKim, KiChurlChang, JongChulBaek, JiKwonPark, JeongKyuShin, WonJunChoi, JongHakLee, WonYoungPaik 저
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- 3,000원
NF-ՊB luciferase activity, and PGE2 and IL-6 production in a dose-dependent fashion. Interestingly, low doses (10ՌM) of DHA and EPA, but not troglitozone, significantly increased the activity of NF-ՊB in resting HUVECs. Our study suggests that while DHA, EPA, and troglitazone may be protective on HUVECs under inflammatory conditions in a dose-dependent manner. However there may be some negative effects when the concentrations are abnormally low, even in normal endothelium.
569.

The Inhibitory Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats

YoungSilMin, SeEunLee, SeungTaeHong, HyunSikKim, Byung-ChulChoi, SangSooSim, WanKyunWhang, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 5 295-300 (6 pages)

YoungSilMin, SeEunLee, SeungTaeHong, HyunSikKim, Byung-ChulChoi, SangSooSim, WanKyunWhang, UyDongSohn 저
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- 3,000원
It was evaluated the inhibitory action of quercetin-3-O-Ղ-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by...
570.

Kainic Acid-induced Neuronal Death is Attenuated by Aminoguanidine but Aggravated by L-NAME in Mouse Hippocampus

Jong-SeonByun, Sang-HyunLee, Seong-HoJeon, Yong-SooKwon, HeeJaeLee, Sung-SooKim, Young-MyeongKim, Myong-JoKim, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 1 265-271 (7 pages)

Jong-SeonByun, Sang-HyunLee, Seong-HoJeon, Yong-SooKwon, HeeJaeLee, Sung-SooKim, Young-MyeongKim, Myong-JoKim, WanjooChun 저
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- 3,000원
Nitric oxide (NO) has both neuroprotective and neurotoxic effects depending on its concentration and the experimental model. We tested the effects of NG-nitro-L-arginine methyl ester (L-NAME), a nonselective nitric oxide synthase (NOS) inhibitor, and aminoguanidine, a selective inducible NOS (iNOS) inhibitor, on kainic acid (KA)-induced seizures and hippocampal CA3 neuronal death. L-NAME (50 mg/kg, i.p.) and/or aminoguanidine (200 mg/kg, i.p.) were administered 1 h prior to the...

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