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51.

Blockade of Kv1.5 channels by the antidepressant drug sertraline

HyangMiLee, SangJuneHahn, BokHeeChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 8 193-200 (8 pages)

HyangMiLee, SangJuneHahn, BokHeeChoi 저
...
- 3,000원
manner, sertraline has been known to inhibit various voltage-dependent channels, which play an important role in regulation of cardiovascular system. In the present study, we investigated the action of sertraline on Kv1.5, which is one of cardiac ion channels. The effect of sertraline on the cloned neuronal rat Kv1.5 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Sertraline reduced Kv1.5 whole-cell currents in a reversible...
52.

Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization

Hyang-AeLee, Sung-AeHyun, Sung-GurlPark, Ki-SukKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 15 119-127 (9 pages)

Hyang-AeLee, Sung-AeHyun, Sung-GurlPark, Ki-SukKim, SungJoonKim 저
...
- 3,000원
Dihydropyridine (DHP) calcium channel blockers (CCBs) have been widely used to treat of several cardiovascular diseases. An excessive shortening of action potential duration (APD) due to the reduction of Ca2+ channel current (ICa) might increase the risk of arrhythmia. In this study we investigated the electrophysiologicaleffects of nicardipine (NIC), isradipine (ISR), and amlodipine (AML) on the cardiac APD in rabbit Purkinje fibers, voltage-gated K+ channel currents (IKr, IKs) and...
53.

Inducibility of human atrial fibrillation in an in silico model reflecting local acetylcholine distribution and concentration

MinkiHwang, Hyun-SeungLee, Hui-NamPak, EunBoShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 14 111-117 (7 pages)

MinkiHwang, Hyun-SeungLee, Hui-NamPak, EunBoShim 저
...
- 3,000원
human atrial action potential model with an ACh-dependent K+ current (IKAch) was used to examine the effect of vagal activation. A simulation of cardiac wave dynamics was performed in a realistic 3D model of the atrium. A model of the ganglionated plexus (GP) and nerve was developed based on the “octopus hypothesis”. The pattern of cardiac wave dynamics was examined by applying vagal activation to the GP areas or randomly. AF inducibility in the octopus hypothesis-based GP and nerve model was...
54.

Blockade of Kv1.5 by paroxetine, an antidepressant drug

HyangMiLee, SangJuneHahn, BokHeeChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 10 75-82 (8 pages)

HyangMiLee, SangJuneHahn, BokHeeChoi 저
...
- 3,000원
SSRI-independent manner. These results suggest that paroxetine may cause side effects on cardiac system. In this study, we investigated the effect of paroxetine on Kv1.5, which is one of cardiac ion channels. The action of paroxetine on the cloned neuronal rat Kv1.5 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Paroxetine reduced Kv1.5 whole-cell currents in a reversible concentration-dependent manner, with an IC50 value and...
55.

Characteristics of K+ Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week

JiWoongAhn, ShinWookKang, SeungCheolAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 11 383-388 (6 pages)

JiWoongAhn, ShinWookKang, SeungCheolAhn 저
...
- 3,000원
single first order Boltzmann equation in the homozygous (cir/cir) mice, while it was expressed by a sum of two first order Boltzmann equations in the heterozygous (+/cir) mice. The K+ current of homozygous (cir/cir) mice was more sensitive to TEA in the 1 to 10 mM range, while the 4-AP sensitivities were not different between the two genotypes. Removal of external Ca2+ did not affect the K+ currents in either genotype, indicating that the higher sensitivity of K+ current to TEA in the homozygous...
56.

Pectin Micro- and Nano-capsules of Retinyl Palmitate as Cosmeceutical Carriers for Stabilized Skin Transport

JieunRo, YeongseokKim, HyeongminKim, KyungheePark, Kwon-EunLee, PrakashKhadka, GyiaeYun, JuhyunPark, SukTaiChang, JonghwiLee, JiHoonJeong, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 9 59-64 (6 pages)

JieunRo, YeongseokKim, HyeongminKim, KyungheePark, Kwon-EunLee, PrakashKhadka, GyiaeYun, JuhyunPark, SukTaiChang, JonghwiLee, JiHoonJeong, 저
...
- 3,000원
Retinyl palmitate (RP)-loaded pectinate micro- and nano-particles (PMP and PNP) were designed for stabilization of RP that is widely used as an anti-wrinkle agent in anti-aging cosmeceuticals. PMP/PNP were prepared with an ionotropic gelation method, and anti-oxidative activity of the particles was measured with a DPPH assay. The stability of RP in the particles along with pectin gel and ethanolic solution was then evaluated. In vitro release and skin permeation studies were performed using...
57.

Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.

Wan-SuKim, WooJinChoi, SunwooLee, WooJoongKim, DongChaeLee, , UyDongSohn, Hyoung-ShikShin, WonyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 4 21-28 (8 pages)

Wan-SuKim, WooJinChoi, SunwooLee, WooJoongKim, DongChaeLee, , UyDongSohn, Hyoung-ShikShin, WonyongKim 저
...
- 3,000원
The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin- containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and pro- inflammatory cytokine (IL-1β, IL-6, and IL-10) production. Antioxidant activity evaluations revealed...
58.

Seasonal Acclimatization in Summer versus Winter to Changes in the Sweating Response during Passive Heating in Korean Young Adult Men

Jeong-BeomLee, Tae-WookKim, Young-KiMin, Hun-MoYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 2 9-14 (6 pages)

Jeong-BeomLee, Tae-WookKim, Young-KiMin, Hun-MoYang 저
...
- 3,000원
We investigated the sweating response during passive heating (partial submersion up to the umbilical line in 42±0.5oC water, 30 min) after summer and winter seasonal acclimatization (SA). Testing was performed in July during the summer, 2011 [summer-SA; temp, 25.6±1.8oC; relative humidity (RH), 82.1±8.2%] and in January during the winter, 2012 (winter-SA; temp, −2.7±2.9oC; RH, 65.0±13.1%) in Cheonan (126o52'N, 33.38'E), Republic of Korea. All experiments were carried out in an...
59.

Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men

HyunSeokBang, DaeYunSeo, YongMinChung, Kyoung-MoOh, JungJunPark, FigueroaArturo6, Seung-HunJeong, NariKim, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 13 441-446 (6 pages)

HyunSeokBang, DaeYunSeo, YongMinChung, Kyoung-MoOh, JungJunPark, FigueroaArturo6, Seung-HunJeong, NariKim, JinHan 저
...
- 3,000원
Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on skeletal muscle development and related factors in men. Sixteen healthy male participants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m2) were randomly assigned to RT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of intervention consisting of 5 sets of...
60.

Cyanidin-3-glucoside Inhibits ATP-induced Intracellular Free Ca2＋ Concentration, ROS Formation and Mitochondrial Depolarization in PC12 Cells

ShaziaPerveen, JiSeonYang, TaeJoungHa, ShinHeeYoon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 3 297-305 (9 pages)

ShaziaPerveen, JiSeonYang, TaeJoungHa, ShinHeeYoon 저
...
- 3,000원
Flavonoids have an ability to suppress various ion channels. We determined whether one of flavonoids, cyanidin-3-glucoside, affects adenosine 5'-triphosphate (ATP)-induced calcium signaling using digital imaging methods for intracellular free Ca2＋ concentration ([Ca2＋]i), reactive oxygen species (ROS) and mitochondrial membrane potential in PC12 cells. Treatment with ATP (100μM) for 90 sec induced [Ca2＋]i increases in PC12 cells. Pretreatment with cyanidin-3-glucoside (1μg/ml to 100μg/ml)...

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