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새로운 Platinum (II) Complex ([Pt (II)(trans-1-dach)(DPPP)] (NO3)2와 [Pt (II)(trans-1-dach)(DPPE)] (NO3)2의 항암효과 및 신독성에 관한연구
정지창(Jee-Chang Jung), 윤진희(Chin-Hee Yoon), 장성구(Sung-Goo Chang), 이경태(Kyung-Tae Lee), 노영수(Young-Soo Rho) 대한약리학회 대한약리학잡지 13 Pages
대한약리학회 대한약리학잡지 1993, 제 29권 제 2호 14 283-295 (13 pages)
일부 malignant tumor에 Pt-complex의 임상 응용 과정에서 신장독성등의 심한 부작용이 문제점으로 지적되고 있다. 이 연구에서는 기존의 cisplatin보다 항암효과는 우수하면서, 부작용을 감소시킨 새로운 Pt-complex의 개발에 역점을 두었다. 본 연구에서는 합성한 Pt (II) complex는 carrier ligand로서 1, 2-diaminocyclohexane (dach)을 사용하였고, leaving group으로는 diphosphine류인 1, 3-bis (diphenylphosphine)의 propane (DPPP) 및 ethane (DPPE)을 도입하였으며, 물에 대한 용해도를 높이기 위해 dinitrate로 만들었다.... -
Procainamide와 그 대사산물(N-acetylprocainamide)의 약동학적 분석에 관한 연구
장인진(In-Jin Chang), 신재국(Jae-Gook Shin), 신상구(Sang-Goo Shin), 박찬웅(Chan-Woong Park), 임정규(Jung-Kyoo Lim) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1989, 제 25권 제 1호 12 101-108 (8 pages)
Procainamide를 투여후 이 약물 및 활성형 대사산물인 N-acetylprocainamide (NAPA)의 약동학적 성상을 알아보기 위해 숫컷 성견 5마리에 procainamide 및 NAPA를 교차 투여하여 얻은 혈장농도 data를 2-compartmental model에 의해 약동학적 분석을 시행하여 다음과 같은 결과를 얻었다. 1. 10mg/kg의 procainamide를 1회 15분간 정주후 혈장 procainamide 농도변화는 명백한 분포기와 소실기를 보였으며 생성된 NAPA의 혈장농도는 시간경과에 따라 최고혈장농도는 0.124μg/ml 이하이었으며 정주 직후 조직분포에 따른 혈장농도의... -
A Cultural-Historical View of Child Development: Key Concepts for Going Beyond a Universal View of the Child
Marilyn Fleer 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 19 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2015, Vol.9 No.1 2 19-37 (19 pages)
A developmental view of child development with its biological imperatives has been extensively critiqued over the years and found to be wanting from a range of cultural (Rogoff, 2003; Howes, 2010), social (Qvortrup, Corsaro & Honig, 2009) and even health (Bendelow, 2009; Rogoff, 2011) reasons. But what has been missing from these debates has been a theoretically robust presentation of another way of conceptualizing children’s development (Hedegaard & Fleer, 2013). In drawing upon... -
Metacognition in 3-6 Years Old:Evidence from a Kindergarten in Hong Kong
Vicky Wong Wing Kei 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 29 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2013, Vol.7 No.1 1 1-29 (29 pages)
The study explores metacognition in young children of 3-6 years old. It presents finding from a study exploring the development of self-regulatory and metacognitive abilities in young children. The study takes the form of a descriptive, interpretative investigation using both quantitative and qualitative research methods. It involved 60 children in a local kindergarten in Hong Kong to participate in three different activities. Children participated in the activities were either done without any... -
Examining the Quality of Part-Day and Full-Day Kindergartens in Looking at Children’s Academic Outcomes
Jennifer A. Vu, Myae Han, Martha J. Buell 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 27 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2012, Vol.6 No.2 1 1-27 (27 pages)
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Re-thinking Human Rights-Based Approach in the Context of Refugee Education
Yeo Subin Sarah, Yoo Sung-Sang 경인교육대학교 교육연구원 교육논총 20 Pages
경인교육대학교 교육연구원 교육논총 제 41권 특별호 4 63-82 (20 pages)
The study aims to critically explore whether the characteristics of the Human Rights-Based Approach (HRBA) are embedded in day-to-day practices and perspectives of stakeholders in the context of refugee education. While scholarly work on refugee education has focused on the refugee population resettled in industrialized countries, the study explores how, and to what extent, the HRBA to education goals set out by the UN are being implemented in the so-called global South contexts where the... -
NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts
VuThiThu, HyoungKyuKim, LeThanhLong, ToThanhThuy, NguyenQuangHuy, SoonHaKim, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 10 305-314 (10 pages)
Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart from ischemia-reperfusion injury. The aim of this study was to further define the role and mechanism of action of NecroX-5 in regulating infl ammation and fi brosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide... -
Awareness and satisfaction of therapeutic goals on functional status in persons with hemiparetic stroke
Si-Nae Ahn, Jeong-Weon Lee, Su-jin Hwang 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2018, 제 7권 제 1호 1 1-5 (5 pages)
Objective: Setting therapeutic goals assist to identify patient priorities and predict problem that may arise in performing daily and functional activities. Goal setting is associated with improved rehabilitation outcomes in individuals with hemiparetic stroke. This study was conducted to assess the effects of having awareness and satisfaction of goals on the functional status of individuals with hemiparetic stroke. Design: Cross-sectional study. Methods: Eighty-one people who had been diagnosed... -
Plyometrics and vibration: no clear winner on efficacy
R. Jeremy Hubbard, Jerrold S. Petrofsky, Everett Lohman, Lee Berk, Donna Thorpe 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 2호 2 86-92 (7 pages)
Objective: Whole body vibration (WBV) and plyometrics are common training techniques which increase strength, blood flow, and lower body force and power. The effects these techniques have on sedentary population is unknown. It is our aim to assess the effectiveness of WBV and plyometrics on sedentary population. Design: Experimental study. Methods: Twenty-seven sedentary subjects were assigned to either the control group, jumping only group, or jumping with vibration group. Jump height (myotest...


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