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591.

Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial Cells

HeeJin, HyeEunYoon, Jae-SeonLee, Jae-KyungKim, SungHoMyung, Yun-SilLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 6 119-124 (6 pages)

HeeJin, HyeEunYoon, Jae-SeonLee, Jae-KyungKim, SungHoMyung, Yun-SilLee 저
...
- 3,000원
The aim of the present study was to assess whether exposure to the combination of an extremely low frequency magnetic field (ELF-MF; 60 Hz, 1 mT or 2 mT) with a stress factor, such as ionizing radiation (IR) or H2O2, results in genomic instability in non-tumorigenic human lung epithelial L132 cells. To this end, the percentages of G2/M-arrested cells and aneuploid cells were examined. Exposure to 0.5 Gy IR or 0.05 mM H2O2 for 9 h resulted in the highest levels of aneuploidy; however, no cells...
592.

Long Term Effect of High Glucose and Phosphate Levels on the OPG/RANK/RANKL/TRAIL System in the Progression of Vascular Calcification in rat Aortic Smooth Muscle Cells

YangHoKang, JungSookJin, SeokManSon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 5 111-118 (8 pages)

YangHoKang, JungSookJin, SeokManSon 저
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- 3,000원
Osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL)/receptor activator of NF-κB (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high glucose (HG) and phosphate (HP) condition for a long-term period (more than 2 weeks) have not been fully determined. In this study, we evaluated the effects of HG and HP levels over 2 or 4 weeks on the progression of vascular...
593.

Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model

LiQinZhu, JianWeiYang, YuanZhang, YongMingWang, JianLeiZhang, YuanYuanZhao, WeiLinDong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 3 99-104 (6 pages)

LiQinZhu, JianWeiYang, YuanZhang, YongMingWang, JianLeiZhang, YuanYuanZhao, WeiLinDong 저
...
- 3,000원
spleen, muscle tissues in human with intra-abdominal infection. The predicted tissue to plasma concentration ratios in abdominal viscera were between 1.1 and 2.2. When rat plasma con-centrations were known, extrapolation of a PBPK model was a method to predict drug pharmacokinetics and penetration in human. Moxifloxacin has a good penetration into liver, kidney, spleen, as well as other tissues in intra-abdominal infected human. Close monitoring are necessary when using moxifloxacin due to its...
594.

Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration

ZhenzhenHu, Eun-HyeOh, YeonBokChung, JinTaeHong, Ki-WanOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 2 89-97 (9 pages)

ZhenzhenHu, Eun-HyeOh, YeonBokChung, JinTaeHong, Ki-WanOh 저
...
- 3,000원
The aim of this study was to investigate the involvement of dopaminergic receptors (DR) in behavioral sensitization, as measured by locomotor activity, and the over-expression of cocaine- and amphetamine-regulated transcript (CART) peptides after repeated administration of cocaine in mice. Repeated administrations of cocaine induced behavioral sensitization and CART over-expression in mice. The levels of striatal CART mRNA were significantly increased on the 3rd day. CART peptides were...
595.

Airway Smooth Muscle Sensitivity to Methacholine in Precision-Cut Lung Slices (PCLS) from Ovalbumin-induced Asthmatic Mice

HaeJinKim, YeryungKim, SuJungPark, BoramBae, Hye-RyunKang, Sang-HeonCho, HaeYoungYoo, JooHyunNam, WooKyungKim, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 10 65-72 (8 pages)

HaeJinKim, YeryungKim, SuJungPark, BoramBae, Hye-RyunKang, Sang-HeonCho, HaeYoungYoo, JooHyunNam, WooKyungKim, SungJoonKim 저
...
- 3,000원
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR) and reversible airway obstruction. Methacholine (MCh) is widely used in broncho-provocation test to evaluate airway resistance. For experimental investigation, ovalbumin-induced sensitization is fre-quently used in rodents (Ova-asthma). However, albeit the inflammatory histology and AHR in vivo, it remains unclear whether the MCh sensitivity of airway smooth muscle isolated from Ova-asthma is persistently...
596.

Pectin Micro- and Nano-capsules of Retinyl Palmitate as Cosmeceutical Carriers for Stabilized Skin Transport

JieunRo, YeongseokKim, HyeongminKim, KyungheePark, Kwon-EunLee, PrakashKhadka, GyiaeYun, JuhyunPark, SukTaiChang, JonghwiLee, JiHoonJeong, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 9 59-64 (6 pages)

JieunRo, YeongseokKim, HyeongminKim, KyungheePark, Kwon-EunLee, PrakashKhadka, GyiaeYun, JuhyunPark, SukTaiChang, JonghwiLee, JiHoonJeong, 저
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- 3,000원
Retinyl palmitate (RP)-loaded pectinate micro- and nano-particles (PMP and PNP) were designed for stabilization of RP that is widely used as an anti-wrinkle agent in anti-aging cosmeceuticals. PMP/PNP were prepared with an ionotropic gelation method, and anti-oxidative activity of the particles was measured with a DPPH assay. The stability of RP in the particles along with pectin gel and ethanolic solution was then evaluated. In vitro release and skin permeation studies were performed using...
597.

Anti-inflammatory Effects of Flavonoids on TNBS-induced Colitis of Rats

MinjaeJoo, HanSangKim, TaeHoonKwon, AlishaPalikhe, TinSarZaw, JiHoonJeong, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 7 43-50 (8 pages)

MinjaeJoo, HanSangKim, TaeHoonKwon, AlishaPalikhe, TinSarZaw, JiHoonJeong, UyDongSohn 저
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- 3,000원
It has been shown that the extracts including eupatilin and quercetin-3-β-D-glucuronopyranoside had mucoprotective effects on the esophagus and stomach through their antioxidant activities. This study was designed to investigate the anti-inflammatory effect of these flavonoid compounds in an animal model of inflammatory bowel disease induced by 2,4,6-trinitrobenzene sulfonic acid. Experimental colitis was induced by intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid. Extracts...
598.

Isolation and In Vitro Culture of Vascular Endothelial Cells from Mice

ShinkyuChoi, JiAeeKim, KwanChangKim, SukHyoSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 6 35-42 (8 pages)

ShinkyuChoi, JiAeeKim, KwanChangKim, SukHyoSuh 저
...
- 3,000원
culture, we applied shearing stress and anti-fibroblast antibody. EC were characterized by a monolayer cobble stone appearance, positive staining with acetylated low density lipoprotein labeled with 1,1’-dioctadecyl-3,3,3’,3’-tetramethyl-indocarbocyanine perchlorate, RT-PCR using primers for von-Willebrand factor, and determination of the protein level endothelial nitric oxide synthase. Our simple, efficient method would facilitate in vitro functional investigations of EC from mouse vessels.
599.

Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.

Wan-SuKim, WooJinChoi, SunwooLee, WooJoongKim, DongChaeLee, , UyDongSohn, Hyoung-ShikShin, WonyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 4 21-28 (8 pages)

Wan-SuKim, WooJinChoi, SunwooLee, WooJoongKim, DongChaeLee, , UyDongSohn, Hyoung-ShikShin, WonyongKim 저
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- 3,000원
The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin- containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and pro- inflammatory cytokine (IL-1β, IL-6, and IL-10) production. Antioxidant activity evaluations revealed...
600.

Berberine Prevents Intestinal Mucosal Barrier Damage During Early Phase of Sepsis in Rat through the Toll-Like Receptors Signaling Pathway

Guo-xunLi, Xi-moWang, TaoJiang, Jian-fengGong, Ling-yingNiu, NingLi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 1 1-8 (8 pages)

Guo-xunLi, Xi-moWang, TaoJiang, Jian-fengGong, Ling-yingNiu, NingLi 저
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- 3,000원
Our previous study has shown berberine prevents damage to the intestinal mucosal barrier during early phase of sepsis in rat through mechanisms independent of the NOD-like receptors signaling pathway. In this study, we explored the regulatory effects of berberine on Toll-like receptors during the intestinal mucosal damaging process in rats. Male Sprague-Dawlay (SD) rats were treated with berberine for 5 d before undergoing cecal ligation and puncture (CLP) to induce polymicrobial sepsis. The...

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