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681.

Influence of ω-Conotoxin GVIA, Nifedipine and Cilnidipine on Catecholamine Release in the Rat Adrenal Medulla

Byung-SikYu, Byeong-CheolKim, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 4 21-30 (10 pages)

Byung-SikYu, Byeong-CheolKim, Dong-YoonLim 저
...
- 3,000원
The present study was designed to establish comparatively the inhibitory effects of cilnidipine (CNP), nifedipine (NIF), and ω-conotoxin GVIA (CTX) on the release of CA evoked by cholinergic stimulation and membrane depolarization from the isolated perfused model of the rat adrenal medulla. CNP (3 μM), NIF (3μM), and CTX (3μM) perfused into an adrenal vein for 60 min produced greatly inhibition in CA secretory responses evoked by ACh (5.32⁓10⁣3 M), DMPP (10⁣4 M for 2 min),...
682.

Effects of Phosphodiesterase 5 Inhibition with Sildenafil on Atrial Contractile and Secretory Function

HeXiuQuan, SunYoungKim, XuanShunJin, JongKwanPark, SungZooKim, KyungWooCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 6 149-154 (6 pages)

HeXiuQuan, SunYoungKim, XuanShunJin, JongKwanPark, SungZooKim, KyungWooCho 저
...
- 3,000원
Selective inhibition of phosphodiesterase (PDE) 5 opened a new therapeutic approach for cardiovascular disorders. Therefore, the effect of PDE5 inhibition on the cardiac function should thoroughly be defined. The purpose of the present study was to define the effects of sildenafil, a selective inhibitor of PDE5, on the atrial cGMP efflux, atrial dynamics, and the release of atrial natriuretic peptide (ANP). By perfusing rabbit left atria to allow atrial pacing, changes in atrial stroke volume...
683.

Effects of Phenylephrine on the Excitability of Medial Vestibular Nuclear Neurons in Rats

Han-SeongJeong, HaeRyongHuh, Myung-JooJang, Seol-HeeHong, SujeongJang, JinPark, Seung-HanLee, Jae-HaKim, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 3 131-136 (6 pages)

Han-SeongJeong, HaeRyongHuh, Myung-JooJang, Seol-HeeHong, SujeongJang, JinPark, Seung-HanLee, Jae-HaKim, Jong-SeongPark 저
...
- 3,000원
Coeruleo-vestibular pathway which connects locus coeruleus and vestibular nuclei is noradrenergic. This study was designed to elucidate the effects of phenylephrine on the spontaneous activity of acutely isolated medial vestibular nuclear neurons of rat by whole-cell patch-clamp technique. Sprague-Dawley rats, aged 14 to 16 days, were used. After enzymatic digestion, dissociated medial vestibular neurons were transferred to a recording chamber mounted on an inverted microscope, and spontaneous...
684.

Effects of Zinc on Spontaneous Miniature GABA Release in Rat Hippocampal CA3 Pyramidal Neurons

Byung-JuChoi, Il-SungJang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 1 59-64 (6 pages)

Byung-JuChoi, Il-SungJang 저
...
- 3,000원
The effects of Zn2⁢ on spontaneous glutamate and GABA release were tested in mechanically dissociated rat CA3 pyramidal neurons which retained functional presynaptic nerve terminals. The spontaneous miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs, respectively) were pharmacologically isolated and recorded using whole-cell patch clamp technique under voltage-clamp conditions. Zn2⁢ at a lower concentration (30μM) increased GABAergic mIPSC frequency without...
685.

Fluoxetine Modulates Corticostriatal Synaptic Transmission through Postsynaptic Mechanism

HyeongSeokCho, SeJoonChoi, Ki-JungKim, HyunHoLee, YoungJinCho, SeongYunKim, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 6 31-38 (8 pages)

HyeongSeokCho, SeJoonChoi, Ki-JungKim, HyunHoLee, YoungJinCho, SeongYunKim, Ki-WugSung 저
...
- 3,000원
Fluoxetine, widely used for the treatment of depression, is known to be a selective serotonin reuptake inhibitor (SSRI), however, there are also reports that fluoxetine has direct effects on several receptors. Employing whole-cell patch clamp techniques in rat brain slice, we studied the effects of fluoxetine on corticostriatal synaptic transmission by measuring the change in spontaneous excitatory postsynaptic currents (sEPSC). Acute treatment of rat brain slice with fluoxetine (10μM)...
686.

Direct Block of Cloned K+ Channels, Kv1.5 and Kv1.3, by Cyclosporin A, Independent of Calcineurin Inhibition

BokHeeChoi, SangJuneHahn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 7 353-362 (10 pages)

BokHeeChoi, SangJuneHahn 저
...
- 3,000원
The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique. CsA reversibly blocked Kv1.5 currents at ⁢50 mV in a reversible concentration- dependent manner with an apparent IC50 of 1.0μM. Other calcineurin inhibitors (cypermethrin, autoinhibitory peptide) had no effect on Kv1.5 and did not prevent the inhibitory effect of CsA....
687.

Effects of a δ-opioid Agonist on the Brainstem Vestibular Nuclear Neuronal Activity of Rats

Tae-SunKim, MeiHuang, Myung-JooJang, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 1 137-142 (6 pages)

Tae-SunKim, MeiHuang, Myung-JooJang, Han-SeongJeong, Jong-SeongPark 저
...
- 3,000원
This study was undertaken to investigate the effects of [D-Ala2, D-Leu5]-enkephalin (DADLE) on the spontaneous activity of medial vestibular nuclear neurons of the rat. Sprague-Dawley rats, aged 14 to 16 days, were anesthetized with ether and decapitated. After enzymatic digestion, the brain stem portion of medial vestibular nuclear neuron was obtained by micropunching. The dissociated neurons were transferred to a recording chamber mounted on an inverted microscope, and spontaneous action...
688.

Effects of PCB Congeners in Rodent Neuronal Cells in Culture

Sun-YoungKimJae-HoYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 2 9-16 (8 pages)

Sun-YoungKimJae-HoYang 저
...
- 3,000원
We attempted to analyze the mechanism of polychlorinated biphenyl (PCB)-induced neurotoxicity and identify the target molecules in the neuronal cells for PCBs.Since the developing neuron is particularly sensitive to PCB-induced neurotoxicity, we isolated cerebellar granule cells derived from 7-day old Sprague Dawley (SD) rats and grew cells in culture for additional 7 days to mimic PND-14 conditions. Only non-coplanar PCBs at a high dose showed a significant increase of total protein kinase C...
689.

Postischemic Treatment with Aminoguanidine Inhibits Peroxynitrite Production in the Peroxynitrite Production in the Rat Hippocampus Following Transient Forebrain Ischemia

Yun-SikChoi, Yeo-HongYoon, JuEunLee, Kyung-OkCho, SeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 1 1-5 (5 pages)

Yun-SikChoi, Yeo-HongYoon, JuEunLee, Kyung-OkCho, SeongYunKim 저
...
- 1,500원
Transient forebrain ischemia results in the delayed neuronal death in the CA1 area of the hippocampus. The present study was performed to determine effects of aminoguanidine, a selective iNOS inhibitor, on the generation of peroxynitrite and delayed neuronal death occurring in the hippocampus following transient forebrain ischemia. Transient forebrain ischemia was produced in the conscious rats by four-vessel occlusion for 10 min. Treatment with aminoguanidine (100 mg/kg or 200 mg/kg, i.p.) or...
690.

Dietary Ascorbate Supplementation Reduces Oxidative Tissue Damage and Expression of iNOS in the Kidney of Streptozotocin Induced Diabetic Rats

MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 8 39-45 (7 pages)

MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 저
...
- 3,000원
Reactive oxygen species (ROS) have been suggested to be contributory factors in complications of diabetes mellitus. In the present study, we investigated the generation of superoxide, the lipid peroxide level measured as thiobarbituric acid reactive substances, the vasorelaxation of isolated thoracic aorta and the iNOS expression in kidney of streptozotocin induced diabetic rats. Sprague Dawley rats were divided into four groups: control, ascorbate (400 mg/kg rat weight daily in drinking water),...

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