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- 대한신경정신의학회(379)
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- 신경정신의학(378)
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YKP1447, A Novel Potential Atypical Antipsychotic Agent
SeonMinDong, YongGilKim, JoonHeo, MiKyungJi, JeongWooCho, ByongSungKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 1 71-78 (8 pages)
(S)-Carbamic acid 2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-1-phenyl-ethyl ester hydrochloride (YKP1447) is a novel "atypical" antipsychotic drug which selectively binds to serotonin (5-HT2A, Ki=0.61 nM, 5-HT2C, Ki=20.7 nM) and dopamine (D2, Ki=45.9 nM, D3, Ki=42.1 nM) receptors with over 10∼100-fold selectivity over the various receptors which exist in the brain. In the behavioral studies using mice, YKP1447 antagonized the apomorphine-induced cage climbing (ED50=0.93 mg/kg) and DOI-induced head... -
Roles of Dopaminergic D1 and D2 Receptors in Catecholamine Release from the Rat Adrenal Medulla
YoungJooBaek, YooSeongSeo, DongYoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.1 3 13-24 (12 pages)
The aim of the present study was designed to establish comparatively the inhibitory effects of D1-like and D2-like dopaminergic receptor agonists, SKF81297 and R(-)-TNPA on the release of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused model of the rat adrenal medulla. SKF81297 (30ՌM) and R-(-)-TNPA (30ՌM) perfused into an adrenal vein for 60 min, produced great inhibition in the CA secretory responses evoked by ACh... -
Influence of SKF81297 on Catecholamine Release from the Perfused Rat Adrenal Medulla
Deok-HoChoi, Jong-HeeCha, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 6 197-206 (10 pages)
The aim of the present study was to investigate the effects of 6-chloro-7,8-dihydroxy-1-phenyl-2,3, 4,5-tetrahydro-1H-3-benzazepine (SKF81297), a selective agonist of dopaminergic D1 receptor, on the secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane-depolarization in the isolated perfused rat adrenal gland, and also to elucidate the mechanism involved. SKF81297 (10∼100μM) perfused into an adrenal vein for 60 min produced dose- and time-dependent inhibition of CA... -
R-(-)-TNPA, a Dopaminergic D2 Receptor Agonist, Inhibits Catecholamine Release from the Rat Adrenal Medulla
Soon-PyoHong, Hong-JooSeo, Dong-YoonLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 8 273-282 (10 pages)
The aim of the present study was to investigate the effects of R-()-2,10,11-trihydroxy-N-propylnoraporphine [R-()-TNPA], a selective agonist of dopaminergic D2 receptor and S()-raclopride, a selective antagonist of dopaminergic D2 receptor, on the secretion of catecholamines (CA) evoked by cholinergic stimulation and membrane-depolarization in the isolated perfused model of the rat adrenal gland, and also to establish its mechanism of action. R-()-TNPA (10∼100μM)... -
Dopamine Modulates Corticostriatal Synaptic Transmission through Both D1 and D2 Receptor Subtypes in Rat Brain
HyunHoLee, SeJoonChoi, Ki-JungKim, HyeongSeokCho, SeongYunKim, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 2 263-268 (6 pages)
Striatum has important roles in motor control, habitual learning and memory. It receives glutamatergic inputs from neocortex and thalamus, and dopaminergic inputs from substantia nigra. We examined effects of dopamine (DA) on the corticostriatal synaptic transmission using in vitro extracellular recording technique in rat brain corticostriatal slices. Synaptic responses were elicited by stimulation of cortical glutamatergic inputs on the corpus callosum and recorded in the dorsal striatum.... -
Differential Effects of Typical and Atypical Antipsychotics on MK- 801-induced EEG Changes in Rats
JeeSookKwon, KiMinKim, SuMinChang, Choong-YoungKim, TaiHoChung, Byung-JuChoi, MaanGeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.1 3 17-22 (6 pages)
(5 mg/kg, i.p.) and haloperidol (0.5 mg/kg, i.p.) were differ from that by atypical antipsychotic clozapine (5 mg/kg, i.p.) in the rats treated with or without MK-801 treatment (0.2 mg/kg, i.p.) which produce behavioral abnormalities like hyperlocomotion and stereotypy. The dissimilarity between the states produced by antipsychotics and the control state was examined with the distance of the location of the canonical variables calculated by stepwise discriminant analysis with the relative band... -
Electroencephalographic Effects of Chlorpromazine in Rats
JeongEYunMaanGeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 2 245-250 (6 pages)
The effects of an antipsychotic, chlorpromazine, on the electroencephalogram (EEG) were observed while rats were awake but immobile. The time course and the dose-dependency of the EEG changes were examined. The method of the power spectrum analysis was used to examine the EEG changes by the drug. The bands were divided into delta (1∼3.5 Hz), theta (3.5∼8 Hz), alpha (8∼13 Hz), beta1 (13∼21 Hz), beta2 (21∼30 Hz) and gamma (30∼50 Hz). In rats, the low dose of chlropromazine (1 mg/kg, i.p.)... -
Dopaminergic Inhibition of Dorsal Horn Cell Activity in the Cat
KyungChulKim, HongKeeShin, KeeSoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 2 661-670 (10 pages)
Dopamine has been generally known to exert antinociceptive action in behavioral pain test, such as tail flick and hot plate test, but there appears to be a great variance in the reports on the antinociceptive effect of dopamine depending on the dosage and route of drug administration and type of animal preparation. In the present study, the effects of dopamine on the responses of wide dynamic range (WDR) cells to mechanical, thermal and graded electrical stimuli were investigated, and the... -
치료 저항성 조현병의 이해와 치료
김의태(Euitae Kim) 대한신경정신의학회 신경정신의학 5 Pages
대한신경정신의학회 신경정신의학 2018, 제 57권 제 3호 4 230-234 (5 pages)
