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전체 선택해제
총 732건 검색
본문검색 결과만 보기
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Regulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice
ChorongJang, JiHeeLim, CheolWheePark, Young-JinCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 8 299-306 (8 pages)
Calcineurin (CaN) is activated in diabetes and plays a role in glomerular hypertrophy and extracellular matrix (ECM) accumulation. Here, kidneys from diabetic model mice were investigated for the expression of the regulator of CaN 1 (RCAN1) isoform 4 (RCAN1.4) which had been shown to be transcriptionally upregulated by CaN activation. We found the increased immunoreactivity for RCAN1 in the glomerular cells of db/db mice and streptozotocin-induced diabetic mice. In concordance, the expression of... -
Inhibition of Angiotensin II-Induced Vascular Smooth Muscle Cell Hypertrophy by Different Catechins
YingZheng, HyeJinSong, SeokHeeYun, YeonJeongChae, HaoJia, ChanHyungKim, TaeSunHa, AgapiosSachinidis, HeeYulAhn, SraT.Davidge 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.2 7 117-124 (8 pages)
A cumulative evidence indicates that consumption of tea catechin, flavan-3-ol derived from green tea leaves, lowers the risk of cardiovascular diseases. However, a precise mechanism for this cardiovascular action has not yet been fully understood. In the present study, we investigated the effects of different green tea catechins, such as epigallocatechin-3 gallate (EGCG), epigallocatechin (EGC), epicatechin-3 gallate (ECG), and epicatechin (EC), on angiotensin II (Ang II)-induced hypertrophy in... -
Upregulation of Heat Shock Proteins in the Kidney in Hypertension
GeonLee, YoonWhaOh, JongUnLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 5 147-152 (6 pages)
The present study was undertaken to determine the regulation of heat shock proteins (HSP) in the kidney in hypertension. Two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA)-salt hypertension was induced in male Sprague-Dawley rats. At weeks 1 and 4 after inducing the hypertension, the expression of HSP70, HSP32 and HSP25 was determined in the kidney by Western blot analysis. In 2K1C hypertension, the expression of HSP70, HSP32 and HSP25 was increased in the clipped kidney at both... -
Role of Calmodulin in the Generation of Reactive Oxygen Species and Apoptosis Induced by Tamoxifen in HepG2 Human Hepatoma Cells
YongSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.4 3 187-192 (6 pages)
Tamoxifen, an antiestrogen, has previously been shown to induce apoptosis in HepG2 human hepatoblastoma cells through activation of the pathways independent of estrogen receptors, i.e., intracellular Ca2 increase and generation of reactive oxygen species (ROS). However, the mechanism of tamoxifen to link increased intracellular Ca2 to ROS generation is currently unknown. Thus, in this study we investigated the possible involvement of calmodulin, a Ca2 activated protein, and... -
Ethanol Prevents from Acetaminophen Inducible Hepatic Necrosis by Inhibiting its Metabolic Activation in Mice
Sun-MeeLee, Tai-SoonCho, Young-NamCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 15 261-269 (9 pages)
Concomitant administration of a single acute dose of ethanol (4 g/kg) protected mice from the hepatocellular injury observed upon administration of a large dose of acetaminophen (400 mg/kg). This was evidenced by the normal histological appearances of liver sections and by the lowered serum aminotransferase activities in mice treated with ethanol and acetaminophen together. In the mice treated with acetaminophen alone, along with the hepatic necrosis, the hepatic microsomal aminopyrine... -
한국인 알코올 의존 환자의 제2알데히드탈수소효소 유전자형 빈도
백인호, 이철, 이수정, 이창욱, 김정진, 전태연, 한상익, 함웅 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 1호 13 149-158 (10 pages)
연구목적：본 연구는 알코올의 대사과정에서 중요한 제2알데히드 탈수소효소(aldehyde dehydrogenase (ALDH)2)의 유전자형이 알코올 의존의 발병이나 임상 변인과 어떠한 연관성을 갖는지 알아보기 위하여 시 행되었다. 방 법：141명의 알코올의존증환자와 144명의 대조군에서 ALDH2 유전자형을 제한효소법에 의하여 형벌 하고 비교하였으며 환자군에서 ALDH2 유전자형 빈도에 따른 임상 양상의 차이를 조사하였다. 결 과： 1) 알코올 의존증 환자군은 대조군보다 유의하게 ALDH2*1/1의 빈도가 높고 변이형 ALDH2인 ALDH2*1/2 와... -
할로페리돌로 유도한 신경세포 고사에 대한 신경성장인자 및 인슐린 유사 성장인자의 억제효과
강효정, 강지윤, 곽병주, 정영기, 노재성 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 5호 12 920-927 (8 pages)
연구목적： 본 연구는 생쥐 태자의 대뇌피질 세포 일차 배양을 이용하여 할로페리돌로 유도한 신경세포의 사멸에 대 해 신경 성장인자인 brain-dervied neurotrophic factor(BDNF), Neurotrophin 4/5(NT 4/5)와 인슐린 유 사 성장인자인 insulin-like growth factor Ⅰ(IGF-Ⅰ) 및 IGF-Ⅱ의 조절효과를 실험한 것이다. 방 법： 생쥐 태자의 신경세포를 배양한 후 할로페리돌을 처리하여 신경세포의 사멸을 유도하고 이에 대한 성장인 자의 효과를 정량적으로 분석하였다. 결 과： 30 M의 할로페리돌을 배양한 일차 대뇌 피질 신경세포에... -
알코올 사용장애의 내과적 합병증 및 치료 - 알코올성 간질환을 중심으로 -
대한신경정신의학회 신경정신의학 2004, 제 43권 제 6호 4 638-645 (8 pages)
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폐쇄성 수면무호흡증 환자에서 신경인지기능 이상과 수면요인과의 관련성
김성재, 이정희 대한신경정신의학회 신경정신의학 12 Pages
대한신경정신의학회 신경정신의학 2006, 제 45권 제 4호 1 295-306 (12 pages)
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Platelet-Activating Factor Potentiates the Activity of Respiratory Burst and Interleukin-1 in Rat Alveolar Macrophages
Lee, Ji-Hee 대한생리학회 대한생리학회지 8 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 7 251-258 (8 pages)
The objective of the present study was to test the effect of platelet-activating factor (PAF) on rat alveolar macrophages. PAF alone did not stimulate superoxide secretion from alveolar macrophages. However, PAF (10-5 M) significantly enhanced phagocytic activator zymosan-induced superoxide secretion from alveolar macrophages. This enhancement of PAF plus zymosan was 30% above the sum of the separate effects of PAF and zymosan. Similarly, PAF 1.3 X (10-5 M) was not a direct stimulant of...
