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751.

Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells

SangKiLee, JiYoungLee, HeeKyoungJoo, EunJungCho, CukSeongKim, SangDoLee, JinBongPark, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 8 199-204 (6 pages)

SangKiLee, JiYoungLee, HeeKyoungJoo, EunJungCho, CukSeongKim, SangDoLee, JinBongPark, ByeongHwaJeon 저
...
- 3,000원
We evaluated the role of Tat-mediated p66shc transduction on the activation of endothelial nitric oxide synthase in cultured mouse endothelial cells. To construct the Tat-p66shc fusion protein, human full length p66shc cDNA was fused with the Tat-protein transduction domain. Transduction of TAT-p66shc showed a concentration- and time-dependent manner in endothelial cells. Tat-mediated p66shc transduction showed increased hydrogen peroxide and superoxide production, compared with Tat-p66shc...
752.

Hop Extract Produces Antinociception by Acting on Opioid System in Mice

Soo-HyunPark, Yun-BeomSim, Yu-JungKang, Sung-SuKim, Chea-HaKim, Su-jinKim, Jee-YoungSeo, Su-MinLim, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 6 187-192 (6 pages)

Soo-HyunPark, Yun-BeomSim, Yu-JungKang, Sung-SuKim, Chea-HaKim, Su-jinKim, Jee-YoungSeo, Su-MinLim, Hong-WonSuh 저
...
- 3,000원
In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a dose- dependent manner as measured in the acetic acid-induced writhing test. Antinociceptive action of hop extract was maintained at least for 60 min. Moreover, cumulative response time of nociceptive behaviors induced with intraplantar formalin injection was reduced by hop extract treatment during the 2nd...
753.

Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines

InseokJang, ByeongTakJeon, EunAeJeong, Eun-JinKim, DawonKang, JongSilLee, BaekGeunJeong, JinHyunKim6, BongHoiChoi6, JungEunLee, JongWooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 2 159-165 (7 pages)

InseokJang, ByeongTakJeon, EunAeJeong, Eun-JinKim, DawonKang, JongSilLee, BaekGeunJeong, JinHyunKim6, BongHoiChoi6, JungEunLee, JongWooKim 저
...
- 3,000원
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung carcinoma (NSCLC). Although both SCCs and ACs have been characterized histologically and clinically, the precise mechanisms underlying their migration and invasion are not yet known. Here, we address the involvement in NSCLC of the p21-associated kinase1 (Pak1)/LIM kinase1 (LIMK1)/cofilin pathway, which recently has been reported to play a critical role in tumor migration and invasion....
754.

Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse

Soo-HyunPark, Yun-BeomSim, Yu-JungKang, Jin-KooLee, Soon-SungLim, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 6 119-123 (5 pages)

Soo-HyunPark, Yun-BeomSim, Yu-JungKang, Jin-KooLee, Soon-SungLim, Hong-WonSuh 저
...
- 1,500원
In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Agrimonia pilosa Ledeb extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 Ռg) was...
755.

Effects of Protopanaxatriol-Ginsenoside Metabolites on Rat N-Methyl-D-Aspartic Acid Receptor-Mediated Ion Currents

Tae-JoonShin, Sung-HeeHwang, Sun-HyeChoi, Byung-HwanLee, JiyeonKang, Hyeon-JoongKim, R.SuzanneZukin, HyewhonRhim, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 5 113-118 (6 pages)

Tae-JoonShin, Sung-HeeHwang, Sun-HyeChoi, Byung-HwanLee, JiyeonKang, Hyeon-JoongKim, R.SuzanneZukin, HyewhonRhim, Seung-YeolNah 저
...
- 3,000원
with cRNAs encoding NMDA receptor subunits, PPT, but not CK or PPD, reversibly inhibited INMDA in a concentration-dependent manner. The IC50 for PPT on INMDA was 48.1±4.6 ՌM, was non-competitive with NMDA, and was independent of the membrane holding potential. These results demonstrate the possibility that PPT interacts with the NMDA receptor, although not at the NMDA binding site, and that the inhibitory effects of PPT on INMDA could be related to ginseng-mediated neuroprotection.
756.

Altered Regulation of Renal Acid Base Transporters in Response to Ammonium Chloride Loading in Rats

EunYoungKim, JoonSeokChoi, KoEunLee, ChangSeongKim, EunHuiBae, SeongKwonMa, SuhnHeeKim, JongUnLee, SooWanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 2 91-95 (5 pages)

EunYoungKim, JoonSeokChoi, KoEunLee, ChangSeongKim, EunHuiBae, SeongKwonMa, SuhnHeeKim, JongUnLee, SooWanKim 저
...
- 1,500원
The role of the kidney in combating metabolic acidosis has been a subject of considerable interest for many years. The present study was aimed to determine whether there is an altered regulation of renal acid base transporters in acute and chronic acid loading. Male Sprague-Dawley rats were used. Metabolic acidosis was induced by administration of NH4Cl for 2 days (acute) and for 7days (chronic). The serum and urinary pH and bicarbonate were measured. The protein expression of renal acid base...
757.

Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex

Sung-WonPark, Hyun-JongJang, Kwang-HyunCho, , Myung-JunKim, ShinHeeYoon, Duck-JooRhie 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 10 65-70 (6 pages)

Sung-WonPark, Hyun-JongJang, Kwang-HyunCho, , Myung-JunKim, ShinHeeYoon, Duck-JooRhie 저
...
- 3,000원
Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP and LTD during the critical period of the rat visual cortex (postnatal 3∼5 weeks). However, in adult rats, the increase in 5-HT level in the brain by the administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine reinstates ocular dominance plasticity...
758.

A Novel Pathway Underlying the Inhibitory Effects of Melatonin on Isolated Rat Urinary Bladder Contraction

JuneHyunHan, InHoChang, SoonChulMyung, MooYeolLee, WonYongKim, SeoYeonLee, ShinYoungLee6, SeungWookLee, KyungDoKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 6 37-42 (6 pages)

JuneHyunHan, InHoChang, SoonChulMyung, MooYeolLee, WonYongKim, SeoYeonLee, ShinYoungLee6, SeungWookLee, KyungDoKim 저
...
- 3,000원
The aim of the present study was to elucidate the direct effects of melatonin on bladder activity and to determine the mechanisms responsible for the detrusor activity of melatonin in the isolated rat bladder. We evaluated the effects of melatonin on the contractions induced by phenylephrine (PE), acetylcholine (ACh), bethanechol (BCh), KCl, and electrical field stimulation (EFS) in 20 detrusor smooth muscle samples from Sprague-Dawley rats. To determine the mechanisms underlying the inhibitory...
759.

The Characteristics of Supramammillary Cells Projecting to the Hippocampus in Stress Response in the Rat

WoongKiChoi, DavidWirtshafter, Hyun-JungPark, , Mi-SookLee, , SongHer, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 3 17-24 (8 pages)

WoongKiChoi, DavidWirtshafter, Hyun-JungPark, , Mi-SookLee, , SongHer, InsopShim 저
...
- 3,000원
The hypothalamus-pituitary-adrenocortex (HPA) axis is the central mediator of the stress response. The supramammillary (SuM) region is relatively unique among the hypothalamic structures in that it sends a large, direct projection to the hippocampal formation. It has been shown that mild stress could activate the SuM cells that project to the hippocampus. However, the role of these cell populations in modulating the stress response is not known. The present study examined the effect of stress on...
760.

Regulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice

ChorongJang, JiHeeLim, CheolWheePark, Young-JinCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 8 299-306 (8 pages)

ChorongJang, JiHeeLim, CheolWheePark, Young-JinCho 저
...
- 3,000원
Calcineurin (CaN) is activated in diabetes and plays a role in glomerular hypertrophy and extracellular matrix (ECM) accumulation. Here, kidneys from diabetic model mice were investigated for the expression of the regulator of CaN 1 (RCAN1) isoform 4 (RCAN1.4) which had been shown to be transcriptionally upregulated by CaN activation. We found the increased immunoreactivity for RCAN1 in the glomerular cells of db/db mice and streptozotocin-induced diabetic mice. In concordance, the expression of...

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