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전체 선택해제
총 791건 검색
본문검색 결과만 보기
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DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-κB Activity in LPS-treated Human Umbilical Vein Endothelial Cells
SoonAeLee, HyeJungKim, KiChurlChang, JongChulBaek, JiKwonPark, JeongKyuShin, WonJunChoi, JongHakLee, WonYoungPaik 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 6 301-307 (7 pages)
of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on LPS-treated human umbilical vein endothelial cells (HUVECs) to evaluate their cardioprotective potential. Cells were pretreated with DHA, EPA, or troglitazone prior to activation with LPS. Expression of COX-2, prostaglandin E2 (PGE2) and IL-6 production, and NF-ՊB activity were measured by Western blot, ELISA, and luciferase activity, respectively. Results showed that EPA, DHA, or troglitazone significantly reduced COX-2... -
Protein Kinase C-mediated Neuroprotective Action of (－)-epigallocatechin-3-gallate against Aβ1-42-induced Apoptotic Cell Death in SH-SY5Y Neuroblastoma Cells
SujeongJang, KyoungWanYou, Song-HeeKim, SungJunPark, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 1 163-169 (7 pages)
The neurotoxicity of amyloid β (Aβ) is associated with an increased production of reactive oxygen species and apoptosis, and it has been implicated in the development of Alzheimer's disease. While (-)-epigallocatechin-3-gallate (EGCG) suppresses Aβ-induced apoptosis, the mechanisms underlying this process have yet to be completely clarified. This study was designed to investigate whether EGCG plays a neuroprotective role by activating cell survival system such as protein kinase C (PKC),... -
Modulation of Pituitary Somatostatin Receptor Subtype (sst1-5) mRNA Levels by Growth Hormone (GH)-Releasing Hormone in Purified Somatotropes
SeungjoonPark, HeesoonPark, MinaLee, SookjinSohn, EunheeKim, JeechangJung, LawrenceA.Frohman, RhondaD.Kineman 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 5 79-84 (6 pages)
We have previously reported that expression of the somatostatin receptor subtypes, sst1-5, is differentially regulated by growth hormone (GH)-releasing hormone (GHRH) and forskolin (FSK), in vitro. GHRH binds to membrane receptors selectively located on pituitary somatotropes, activates adenylyl cyclase (AC) and increases sst1 and sst2 and decreases sst5 mRNA levels, without significantly altering the expression of sst3 and sst4. In contrast FSK directly activates AC in all pituitary cell types... -
Effects of Acarbose on the Expression of Obese and Neuropeptide Y (NPY) Genes in Mice on High-Carbohydrate Diet
JiyeonKimSunghyunChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 8 433-438 (6 pages)
Two components of the neuroendocrine-hormonal response to long-term treatment of acarbose, adipose tissue-derived leptin and central neuropeptide Y (NPY), were investigated in the ICR mice on a high- carbohydrate diet. Acarbose, administered 5 or 50 mg per 100 g diet for four weeks, dose dependently suppressed body weight gain. The body weight gain was reduced along with the amount of daily food intake in 50 mg acarbose-treated group at 7th and 28th day. 5 or 50 mg acarbose treatment... -
Effects of Dexamethasone and DHEA on the Changes of Glutamate and Polyamine Uptake in Rat Astrocytes by Lipopolysaccharide and Antimycin A
Sang-HyunChoi, BumLee, Kyung-HoShin, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 3 137-146 (10 pages)
Interactions among dexamethasone, dehydroepiandrosterone (DHEA), lipopolysaccharide (LPS), and antimycin A on the glutamate uptake and the polyamine uptake were investigated in primary cultures of rat cerebral cortical astrocytes to examine the effects of dexamethasone and DHEA on the regulatory role of astrocytes in conditions of increased extracellular concentrations of glutamate or polyamines. 1. [3H]Glutamate uptake: LPS and antimycin A decreased Vmax, but both drugs had little effect on... -
Comparision of Regulatory Action of cAMP and cGMP on the Activation of Neutrophil Responses
Chang-HwangHan, Young-ChulYoon, Yong-KyooShin, Eun-SookHan, Chung-SooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 13 97-105 (9 pages)
The regulatory role of cyclic nucleotides in the expression of neutrophil responses has been examined. fMLP-stimulated superoxide production in neutrophils was inhibited by dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP), histamine, adenosinetheophylline, cAMP elevating agents, and 8-bromoguanosine 3',5'-cyclic monophosphate (8-BrcGMP) and sodium nitroprusside, cGMP elevating agents. Staurosporine, a protein kinase C inhibitor, genistein, a protein tyrosine kinase inhibitor and... -
알코올 의존 환자에서의 혈청 성호르몬, 성선자극호르몬, 코티졸 및 프로락틴
서동수, 박두병, 이길홍 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 3호 12 527-536 (10 pages)
연구목적： 알코올 의존 환자들에서 흔히 보이는 성기능장애는 신경병적 요인과 사회심리학적 요인을 배제할 수는 없지 만 내분비 기능의 이상에 의해 기인하는 것으로 알려져왔다. 이러한 내분비 이상을 밝히는 예비적 단계로써 알 코올 의존 환자에서 성호르몬, 성선 자극 호르몬, 코티졸과 프로락틴을 살펴보고자 본 연구를 시행하였다. 방 법： 알코올 의존을 가진 15명의 환자군에서 금단중과 금주후 21일후에 시상하부-뇌하수체-성선축 호르몬 (테스토스테론, 에스트라디올, 황체화 호르몬, 난포자극 호르몬)을 검사하였으며 이축에... -
알코올 의존과 파킨슨병 병태생리에서의 살소리놀(Salsolinol)
정인원, 정성훈, 김진영 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 2008, 제 47권 제 3호 1 217-224 (8 pages)
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정신분열증과 주요 우울장애에서 Natural Killer Cell 수와 백분율 변화
윤장봉, 이재우, 박두병 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1996, 제 35권 제 5호 7 1032-1040 (9 pages)
