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71.

Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1b in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 11 447-453 (7 pages)

KeunsooWon, Sun-MiKim, Sae-ALee, Byung-YongRhim, Seong-KugEo, KoanhoiKim 저
...
- 3,000원
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to understand mechanisms of action of TLR6 in inflammatory responses, we investigated the effects of FSL-1, the TLR6 ligand, on expression of chemokine CCL2 and cytokine IL-1Ղ and determined cellular factors involved in FSL-1-mediated expression of CCL2 and IL-1Ղ in mononuclear cells. Exposure of human monocytic...
72.

Plasminogen Activator Inhibitor-1 Antisense Oligodeoxynucleotides Abrogate Mesangial Fibronectin Accumulation

JehyunPark, JiYeonSeo, HunjooHa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 6 385-390 (6 pages)

JehyunPark, JiYeonSeo, HunjooHa 저
...
- 3,000원
Excessive extracellular matrix (ECM) accumulation is the main feature of chronic renal disease including diabetic nephropathy. Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of plasmin generation and matrix metalloproteinase (MMP) activation. The present study examined the effect of PAI-1 antisense oligodeoxynucleotide (ODN) on fibronectin upregulation and plasmin/MMP suppression in primary mesangial cells cultured...
73.

Activation of PPARα Attenuates IFNγ and IL-1β-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway

Jin-KooLee, Eun-MinSeo, Sang-SooLee, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Seon-MiKim, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 11 185-189 (5 pages)

Jin-KooLee, Eun-MinSeo, Sang-SooLee, Soo-HyunPark, Yun-BeomSim, Jun-SubJung, Seon-MiKim, Hong-WonSuh 저
...
- 1,500원
The present study demonstrates the effect of fibrates, agonists of PPARՁ on cytokines-induced proliferation in primary cultured astrocytes. Alone or combination treatment with cytokines, such as IL-1Ղ (10 ng/ml), IFNՃ (10 ng/ml), and TNF-Ձ (10 ng/ml) cause a significant increase of cell proliferation in a time-dependent manner. Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and 10 ՌM) reduced the IFNՃ and IL-1Ղ-induced cell proliferation...
74.

Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells

DaeGoonYoo, CukSeongKim, SangKiLee, HyoShinKim, EunJungCho, MyoungSooPark, SangDoLee, JinBongPark, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 4 139-144 (6 pages)

DaeGoonYoo, CukSeongKim, SangKiLee, HyoShinKim, EunJungCho, MyoungSooPark, SangDoLee, JinBongPark, ByeongHwaJeon 저
...
- 3,000원
In this study, we evaluated the role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the tumor necrosis factor-Ձ (TNF-Ձ) induced cyclooxygenase-2 (COX-2) expression using A549 lung adenocarcinoma cells. TNF-Ձ induced the expression of COX-2 in A549 cells, but did not induce BEAS-2B expression. The expression of COX-2 in A549 cells was TNF-Ձ dose-dependent (5∼100 ng/ml). TNF-Ձ-stimulated A549 cells evidenced increased Ref-1 expression in a...
75.

p38 MAPK Participates in Muscle-Specific RING Finger 1-Mediated Atrophy in Cast-Immobilized Rat Gastrocnemius Muscle

JunghwanKim, Kyung-JongWon, HwanMyungLee, Byong-YongHwang, Young-MinBae, WhanSooChoi, HyukSong, KiWonLim, Chang-KwonLee, BokyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 13 491-496 (6 pages)

JunghwanKim, Kyung-JongWon, HwanMyungLee, Byong-YongHwang, Young-MinBae, WhanSooChoi, HyukSong, KiWonLim, Chang-KwonLee, BokyungKim 저
...
- 3,000원
Skeletal muscle atrophy is a common phenomenon during the prolonged muscle disuse caused by cast immobilization, extended aging states, bed rest, space flight, or other factors. However, the cellular mechanisms of the atrophic process are poorly understood. In this study, we investigated the involvement of mitogen-activated protein kinase (MAPK) in the expression of muscle-specific RING finger 1 (MuRF1) during atrophy of the rat gastrocnemius muscle. Histological analysis revealed that cast...
76.

Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase

KwonHoLee, SangKiLee, HyoShinKim, EunJungCho, HeeKyoungJoo, EunJiLee, JiYoungLee, MyoungSooPark, SeokJongChang, Chung-HyunCho, JinBongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 4 431-436 (6 pages)

KwonHoLee, SangKiLee, HyoShinKim, EunJungCho, HeeKyoungJoo, EunJiLee, JiYoungLee, MyoungSooPark, SeokJongChang, Chung-HyunCho, JinBongPark 저
...
- 3,000원
The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen...
77.

Role of Caveolin-1 in Indomethacin-induced Death of Human Hepatoadenocarcinoma SK-Hep1 Cells

Kyung-NamKim, Ju-HeeKang, Sung-VinYim, Chang-ShinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 3 143-148 (6 pages)

Kyung-NamKim, Ju-HeeKang, Sung-VinYim, Chang-ShinPark 저
...
- 3,000원
Caveolin-1 (CAV1) is an integral membrane protein that may function as a scaffold for plasma membrane proteins and acts as a tumor suppressor protein. One causative factor of chemotherapy- resistant cancers is P-plycoprotein (P-gp), the product of the multidrug resistance-1 gene (MDR1), which is localized in the caveolar structure. Currently, the interactive roles of CAV1 and MDR1 expression in the death of cancer cells remain controversial. In this study, we investigated the effects of...
78.

Effects of TGF-β;1 Ribbon Antisense on CCl4-induced Liver Fibrosis

Kyung-OhDoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.1 1 1-6 (6 pages)

Kyung-OhDoh 저
...
- 3,000원
Ribbon-type antisense oligonucleotide to TGF-Ղ1 (TGF-Ղ1 RiAS) was designed and tested to prevent or resolve the fibrotic changes induced by CCl4 injection. When Hepa1c1c7 cells were transfected with TGF-Ղ1 RiAS, the level of TGF-Ղ1 mRNA was effectively reduced. TGF-Ղ1 RiAS, mismatched RiAS, and normal saline were each injected...
79.

Protein Kinase C-mediated Neuroprotective Action of (－)-epigallocatechin-3-gallate against Aβ1-42-induced Apoptotic Cell Death in SH-SY5Y Neuroblastoma Cells

SujeongJang, KyoungWanYou, Song-HeeKim, SungJunPark, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 1 163-169 (7 pages)

SujeongJang, KyoungWanYou, Song-HeeKim, SungJunPark, Han-SeongJeong, Jong-SeongPark 저
...
- 3,000원
The neurotoxicity of amyloid β (Aβ) is associated with an increased production of reactive oxygen species and apoptosis, and it has been implicated in the development of Alzheimer's disease. While (-)-epigallocatechin-3-gallate (EGCG) suppresses Aβ-induced apoptosis, the mechanisms underlying this process have yet to be completely clarified. This study was designed to investigate whether EGCG plays a neuroprotective role by activating cell survival system such as protein kinase C (PKC),...
80.

Short-Term High Expression of Interferon-Alpha Modulates Progression of Type 1 Diabetes in NOD Mice

Mi-KyoungPark, Su-YeongSeo, Sook-HeeHong, Hye-JinKim, Eun-JinPark, DukKyuKim, Hye-JeongLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 7 39-44 (6 pages)

Mi-KyoungPark, Su-YeongSeo, Sook-HeeHong, Hye-JinKim, Eun-JinPark, DukKyuKim, Hye-JeongLee 저
...
- 3,000원
Type I diabetes (T1D) is an organ-specific autoimmune disease caused by the T cell-mediated destruction of the insulin-producing β cells in the pancreatic islets. The onset of T1D is the consequence of a progressive destruction of islet β cells mediated by an imbalance between effector CD4⁢ T helper (Th)1 and regulatory CD4⁢ Th2 cell function. Since interferon-alpha (IFN-α) has been known to modulate immune function and autoimmunity, we investigated whether administration of...

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