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71.

Role of inflammasomes in inflammatory autoimmune rheumatic diseases

Young-SuYi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 15 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 1 1-15 (15 pages)

Young-SuYi 저
...
- 4,400원
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin (IL)-1β and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such...
72.

CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model

Jong-SunYoo, Yun-JungLee, JooWonYoon, KyeongEunHyung, KwangWooHwang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 10 349-353 (5 pages)

Jong-SunYoo, Yun-JungLee, JooWonYoon, KyeongEunHyung, KwangWooHwang 저
...
- 1,500원
Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the inhibitory function of CTLA-4 may be attractive in settings of undesirable T cell responses such as autoimmunity or transplant rejection. We have tested the hypothesis that transgenic constitutive expression of CTLA-4 can further attenuate immune responses when compared with normal...
73.

3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells

Jae-WonLee, ChangJunBae, , Yong-JunChoi, Song-InKim, Nam-HoKim, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 4 107-112 (6 pages)

Jae-WonLee, ChangJunBae, , Yong-JunChoi, Song-InKim, Nam-HoKim, HeeJaeLee, Sung-SooKim, Yong-SooKwon, WanjooChun 저
...
- 3,000원
Although various derivatives of caffeic acid have been reported to possess a wide variety of biological activities such as neuronal protection against excitotoxicity and anti-inflammatory property, the biological activity of 3,4,5-trihydroxycinnamic acid (THC), a derivative of hydroxycinnamic acids, has not been clearly examined. The objective of the present study is to evaluate the anti-inflammatory effects of THC on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. THC significantly...
74.

Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring

JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 1 67-82 (16 pages)

JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 저
...
- 4,500원
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the...
75.

Comparison of Interleukin-8 Levels in Long-Distance Runners and Healthy Sedentary Non-Athletic Control Subjects

Young-OhShin, Jun-SangBae, Ji-WonMin, Jeong-BeomLee, Jung-KyuKim, Young-JuSong, Hun-MoYang, Young-KiMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.6 6 263-268 (6 pages)

Young-OhShin, Jun-SangBae, Ji-WonMin, Jeong-BeomLee, Jung-KyuKim, Young-JuSong, Hun-MoYang, Young-KiMin 저
...
- 3,000원
We have previously demonstrated that the level of leukocytes and neutrophils significantly increased immediately and 30 min after exercise. Interleukin-8 (IL-8) is an inflammatory cytokine that acts as a chemokine on neutrophils. In the present study, we evaluated the correlation between the number of neutrophils and leukocytes, and between the number of neutrophils and plasma IL-8 level. Long-distance trained runners (TRs, n = 10) and untrained sedentary control subjects (SEDs, n = 10) ran for...
76.

Natriuresis Induced by Intracerebroventricular Diazepam in Rabbits

Jeong-TaeKohYoung-JohngKook 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 3 555-563 (9 pages)

Jeong-TaeKohYoung-JohngKook 저
...
- 3,000원
The renal function is under regulatory influence of central nervous system (CNS), in which various neurotransmitter and neuromodulator systems take part. However, a possible role of central GABA- benzodiazepine system on the central regulation of renal function has not been explored. This study was undertaken to delineate the renal effects of diazepam. Diazepam, a benzodiazepine agonist, administered into a lateral ventricle (icv) of the rabbit brain in doses ranging from 10 to 100 ㄍg/kg,...
77.

Effects of Glutamate Receptor Antagonists and Protein Synthesis Inhibitor on Delayed Neuronal Death Induced by Transient Global Ischemia in Rat Brain

JunSeogKo, ChoonSangBae, Jong-KeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 2 279-286 (8 pages)

JunSeogKo, ChoonSangBae, Jong-KeunKim 저
...
- 3,000원
It has been well documented that transient forebrain global ischemia causes selective neuronal degeneration in hippocampal CA1 pyramidal neurons with a delay of a few days. The mechanism of this delayed hippocampal CA1 pyramidal neuronal death (DND) is still controversial. To delineate the mechanisms of the DND, the effects of treatment with MK-801, an NMDA receptor antagonist, kynurenic acid, a NMDA/non-NMDA receptor antagonist, and/or cycloheximide, a protein synthesis inhibitor, on the DND...
78.

Cyproheptadine Augmentation of Haloperidol in Chronic Schizophrenic Patients : A Double-Blind Placebo-Controlled Study

Hong Shick Lee, Jin Hak Kim, Young Moon Lee, Eun Sun Han, Man Kwon Kim, Byung Hoon Oh, Sung Kil Min Kae Joon Yoo, Ho Young Lee 대한신경정신의학회 신경정신의학 11 Pages

대한신경정신의학회 신경정신의학 1994, 제 33권 제 1호 23 262-272 (11 pages)

Hong Shick Lee, Jin Hak Kim, Young Moon Lee, Eun Sun Han, Man Kwon Kim, Byung Hoon Oh, Sung Kil Min Kae Joon Yoo, Ho Young Lee 저
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- 4,000원
40명의 만성정신분열증 환자를 대상으로 Haloperdiol에 대한 Cyproheptadine 병용치료 효 과를 검중하기 위하여 6주간의 위약ᅳ대조，이중맹검 연구를 시행하였다. 6주간의 이중맹검 Cyproheptadine 병용치료는 양성 및 음성증상 모두에서 임상적인 중상의 호전을 보였으나 위약과 Haloperidol이 병용 투여된 대조군과 비교한 임상적 정신증상에서는 두군 간의 유의한 통계적 차이는 보이지 않았다. 그러나 Cyproheptadine 병용치료는 대조군에 비해 추체외로 증상의 유의한 감소를 보임으로써 항정신병 약물의 비정형적인 특성이...
79.

알코올중독 환자의 예후 예측에 관한 연구(II) - 가족력 및 DRD2와의 관계를 중심으로 -

성상경, 차성조, 이규항, 이정균 대한신경정신의학회 신경정신의학 12 Pages

대한신경정신의학회 신경정신의학 1996, 제 35권 제 6호 6 1247-1258 (12 pages)

성상경, 차성조, 이규항, 이정균 저
...
- 4,100원
80.

신경펩타이드 : 역사와 개관

Kwang-Soo Kim, Uriel Halbreich 대한신경정신의학회 신경정신의학 12 Pages

대한신경정신의학회 신경정신의학 1988, 제 27권 제 6호 1 943-954 (12 pages)

Kwang-Soo Kim, Uriel Halbreich 저
...
- 4,100원
지난 수십년간 인간의 뇌의 기능에 대한 신경화학적 탐구가 활발히 진행되어 왔으며 1960 년대에 이르러서는 noradrenaline, dopamine, serotonin 및 acetylcholine과 같은 “고전적” 신 경전달물질의 개념이 확립되었으며 내적항정성의 유지 및 인간의 행동과 정신장애에 있어서의 이들의 역할에 관심의 촛점이 맞추어졌다. 그러나 오늘날에 있어서는 최소한 50개 이상의 신경전달물질 혹은 신경조절물질들이 알려져 있으며 이들의 대부분은 최근 20여년간에 밝혀 진 신경펩타이드들이다. 신경펩타이드들의 종류 그리고...

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