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전체 선택해제
총 189건 검색
본문검색 결과만 보기
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Altered Electrophysiological Properties of Coronary Artery in Isoprenaline-Induced Cardiac Hypertrophy
NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 7 413-421 (9 pages)
in the mean single channel current and increase in the open channel noise of KCa channel by TEA were more sensitive in hypertrophy. Kdr current density is significantly reduced in hypertrophy without activation and inactivation kinetics. The sensitivity of Kdr current on 4-AP is significantly increased in hypertrophy. This is the first study to report evidence for alterations of KCa channels and Kdr channels in coronary SMCs with LVH. The findings may provide some insight into mechanism of the... -
Block of ATP-Sensitive K Channels Expressed in Xenopus Oocytes by Dimethyl Sulfoxide
JinBongParkSooWanChae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 6 157-163 (7 pages)
The effects of dimethyl sulfoxide (DMSO) were studied in two groups of Xenopus oocytes, one expressing ATP sensitive K (KATP) channel comprised of sulfonylurea receptor SUR1 and inwardly rectifying K channel subunit Kir6.2, and the other expressing renal KATP channel ROMK2. At concentrations of 0.3∼10% (vol/vol) DMSO inhibited whole cell Kir6.2/SUR1 currents elicited by bath application of sodium azide (3 mM) in a concentration-dependent manner. The inhibition constant and Hill coefficient... -
Differentiation Induction of Dendritic Cell Phenotypes from Human Leukemic Cell Lines
Dae-HeuiLee, JaeSunPark, Wan-KyuEo, WooMiKim, KooilKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 11 79-86 (8 pages)
Recent clinical studies have shown that a high proportion of patients with acute promyelocytic leukemia (APL) achieve complete remission after treatment with all-trans retinoic acid (ATRA). However, most patients who receive continuous treatment with ATRA relapse and develop ATRA-resistant leukemia. Dendritic cells (DCs) are important antigen-presenting cells in the development of antileukemic T-cell responses. In this study, we investigated the strategies to overcome ATRA resistance of APL... -
Changes in the Endothelin-1-induced Contraction of Aorta in Streptozotocin-induced Diabetic Rats
HyunJooCheong, EunJinKim, SuJinKim, SunHeeLee, ByungYongRhim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.3 3 185-195 (11 pages)
Vascular diseases are significant complications of diabetes mellitus (DM), and the endothelial cells may play a pivotal role in the development of vascular disease in DM. Endothelin-1 (ET-1) released from endothelium is a potent vasoconstrictor peptide and circulating level of ET-1 is increased in a variety of disease states. The purpose of this study was to determine the changes of responsiveness to ET-1 in DM, and we experimented on the changes in the ET-1-induced contraction, levels of... -
Transition Metal Induces Apoptosis in MC3T3E1 Osteoblast Evidence of Free Radical Release
Han-JungChae, , Soo-WanChae, Jang-SookKang, Dong-HyeonYun, Byung-GwanBang, Mi-RaKang, Hyung-MinKim, Hyung-RyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.1 7 47-54 (8 pages)
Transition metal ions including Se2, Cd2, Hg2 or Mn2 have been thought to disturb the bone metabolism directly. However, the mechanism for the bone lesion is unknown. In this study, we demonstrated that MC3T3E1 osteoblasts, exposed to various transition metal ions; selenium, cadmium, mercury or manganese, generated massive amounts of reactive oxygen species (ROS). The released ROS were completely quenched by free radical scavengers-N-acetyl cysteine (NAC), reduced... -
Simultaneous HPLC Analysis of Arachidonic Acid Metabolites in Biological Samples with Simple Solid Phase Extraction
Hyung-GunKim, Young-NaHuh, Kun-SukPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 15 779-786 (8 pages)
A reversed-phase high-performance liquid chromatogrphy (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram level. This procedure makes it possible to extract complex mixtures of eicosanoids efficiently with a single step and to analyze them simultaneously by RP-HPLC from biological samples using octadesylsilyl silica extraction column and PGB2 as an internal... -
Inducible Nitric Oxide Synthase mRNA Expression and Nitric Oxide Production in Silica-Induced Acute Inflammatory Lung Injury
JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 12 233-239 (7 pages)
Stimulated alveolar macrophages and neutrophils produce nitric oxide, a free radical by an inducible nitric oxide synthase(iNOS), which reacts with superoxide anion to form peroxynitrite, a more highly reactive toxic species. The objectives of the present study were to evaluate acute inflammatory lung injury and to determine iNOS mRNA induction and nitric oxide production by rat broncho-alveolar lavage cells following intratracheal treatment of silica. After 4 h exposure to silica, differential... -
Changes in Cytosolic Ca2+ but not in cGMP Contents May be more Important to Nitric Oxide-Mediated Relaxation in Depolarized Vascular Smooth Muscle
HyunSeokLeeKiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 8 63-68 (6 pages)
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기니픽의 회장평활근에서 NANC 신경전달물질의 작용기전
이영호, 김종훈, 강복순 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 20 783-796 (14 pages)
Action Mechanisms of NANC Neurotransmitters in Smooth Muscle of Guinea Pig Ileum. 2 -. T1IO .. n r 1 Young-Ho Lee'， Jong-Hoon Kim
