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71.

Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition

HyunDongJe, JiHoonJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 9 69-74 (6 pages)

HyunDongJe, JiHoonJeong 저
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- 3,000원
The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Cardamonin significantly relaxed fluoride-, phenylephrine-, and phorbol ester-induced vascular contractions, suggesting that it has an anti-hypertensive effect on agonist-induced vascular contraction regardless...
72.

The Inhibitory Effect of Eupatilin on the Agonist-Induced Regulation of Vascular Contractility

HyunDongJe, Hyeong-DongKim, JiHoonJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 5 31-36 (6 pages)

HyunDongJe, Hyeong-DongKim, JiHoonJeong 저
...
- 3,000원
The present study was undertaken to investigate the influence of eupatilin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Eupatilin more significantly relaxed fluoride-induced vascular contraction than thromboxane A2 or phorbol ester-induced contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular...
73.

Myoplasmic [Ca2＋], Crossbridge Phosphorylation and Latch in Rabbit Bladder Smooth Muscle

Young-DonKim, Min-HyungCho, Seong-ChunKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 8 171-177 (7 pages)

Young-DonKim, Min-HyungCho, Seong-ChunKwon 저
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- 3,000원
Tonic smooth muscle exhibit the latch phenomenon: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and cellular activation in phasic smooth muscle are unknown. The present study was to determine whether Ca2＋-stimulated MRLC phosphorylation could suffice to explain the agonist- or high K＋-induced contraction in a fast, phasic smooth muscle. We measured myoplasmic [Ca2＋], MRLC...
74.

Magnolol Inhibits LPS-induced NF-κB/Rel Activation by Blocking p38 Kinase in Murine Macrophages

MeiHongLi, GuganKothan, SeungJooCho, PhamThiThuHuong, YongHaiNan, KunYeongLee, SongYubShin, SungSuYea, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 1 353-358 (6 pages)

MeiHongLi, GuganKothan, SeungJooCho, PhamThiThuHuong, YongHaiNan, KunYeongLee, SongYubShin, SungSuYea, YoungJinJeon 저
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- 3,000원
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-ՊB/Rel in RAW 264.7 cells. Immunohisto-chemical staining of iNOS and Western blot analysis showed magnolol to inhibit iNOS gene expression. Reporter gene assay and electrophoretic mobility shift assay showed that magnolol inhibited NF-ՊB/Rel transcriptional activation and DNA binding, respectively....
75.

Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy

HyunjuKim, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, SunghyunKang, VuThiThu, TranMinhKhoa, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 7 299-304 (6 pages)

HyunjuKim, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, SunghyunKang, VuThiThu, TranMinhKhoa, JinHan 저
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- 3,000원
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we examined the molecular mechanism of isoproterenol (ISO)-evoked activation of Ras/Raf/MAPK pathways as well as PKA activity in cerebral artery of rabbits, and we also studied whether the activations of these signaling pathways were altered in cerebral artery,...
76.

Enhancement of ATP-induced Currents by Phospholipase D1 Overexpressed in PC12 Cells

JinBongPark, YoungRaeKim, ByeongHwaJeon, Seung-KielPark, Sae-OckOh, YoungGeunKim, SangDoLee, KwangJinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 6 223-229 (7 pages)

JinBongPark, YoungRaeKim, ByeongHwaJeon, Seung-KielPark, Sae-OckOh, YoungGeunKim, SangDoLee, KwangJinKim 저
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- 3,000원
Using phospholipase D1 (PLD1)-overexpressing PC12 (PLD1-PC12) cells, the regulatory roles of PLD1 on ATP-induced currents were investigated. In control and PLD1-PC12 cells, ATP increased PLD activity in an external Ca2⁢ dependent manner. PLD activity stimulated by ATP was substantially larger in PLD1-PC12 cells than in control cells. In whole-cell voltage-clamp mode, ATP induced transient inward and outward currents. The outward currents inhibited by TEA or charybdotoxin were significantly...
77.

Comparative Analysis of Phospholipase D2 Localization in the Pancreatic Islet of Rat and Guinea Pig

GyeongRyulRyu, Myung-JunKim, Chan-HeeSong, DoSikMin, Duck-JooRhie, Shin-HeeYoon, SangJuneHahn, Myung-SukKim, Yang-HyeokJo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 4 211-215 (5 pages)

GyeongRyulRyu, Myung-JunKim, Chan-HeeSong, DoSikMin, Duck-JooRhie, Shin-HeeYoon, SangJuneHahn, Myung-SukKim, Yang-HyeokJo 저
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- 1,500원
To examine the localization pattern of phospholipase D2 (PLD2) in the pancreatic islet (the islet of Langerhans) depending on species, we conducted a morphological experiment in the rat and guinea pig. Since individual islets display a typical topography with a central core of B cell mass and a peripheral boundary of A, D, and PP cells, double immunofluorescent staining with a panel of antibodies was performed to identify PLD2-immunoreactive cells in the islets PLD2 immunoreactivity was mainly...
78.

Sodium nitroprusside와 Forskolin의 Phorbol ester 수축에 대한 혈관이완작용의 기전

안희열(Hee Yul Ahn) 대한약리학회 대한약리학잡지 8 Pages

대한약리학회 대한약리학잡지 1995, 제 31권 제 3호 4 291-298 (8 pages)

안희열(Hee Yul Ahn) 저
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- 3,000원
본 연구의 목적은 protein kinase C의 활성물질인 phorbol ester의 수축에 대한 cGMP 및 cAMP의 조절기전을 명확히 하기 위하여 흰쥐의 대동맥을 재료로 실험을 수행하였다. Sodium nitroprusside는 guanylyl cyclase를 활성화시켜 cGMP를, forskolin은 adenylyl cyclase를 활성화시켜서 cAMP를 증가시키는 것으로 보고되어 있으므로 위의 두 약물을 선택하였다. Phorbol ester는 시간경과와 함께 지속적인 수축을 발생하였으며 30분경 안정상태에 도달하였다. 동시에 20-kDa myosin light chain (MLC)의 인산화도 증가하였으며 30분경...
79.

선천성 고혈압쥐에서의 Opioid에 의한 진통작용과 Proenkephalin유전자 발현에 대한 연구

서홍원(Hong-Won Suh), 이태희(Tae-Hee Lee), 송동근(Dong-Keun Song), 최성란(Seong-Ran Choi), 정전섭(Jun-Sub Jung), 김영희(Yung-Hi Kim) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1995, 제 31권 제 1호 3 17-26 (10 pages)

서홍원(Hong-Won Suh), 이태희(Tae-Hee Lee), 송동근(Dong-Keun Song), 최성란(Seong-Ran Choi), 정전섭(Jun-Sub Jung), 김영희(Yung-Hi Kim) 저
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- 3,000원
8주, 18주, 그리고 32주된 Spontaneously Hypertensive Rats (SHR)과 Wistar-Kyoto Rats(WKY)과의 blood pressure(혈압)를 측정하여본 결과 SHR 그룹이 WKY에 비해 19에서 70 mmHg 차이로 SHR 그룹이 WKY group에 비하여 혈압이 높았다. 18주된 SHR과 WKY에서 제 3 뇌실내 (intraventricular)로 투여된 morphine과 β-endorphin의 진통작용을 검색하여 보았다. WKY group에 비하여 SHR group에서 뇌실내로 투여된 β-endorphin은 진통작용에 있어서 상승작용 (potentiation)을 보임을 발견하였고 뇌실내로 투여된 morphine은 SHR...
80.

α-독으로 처리한 토끼창간막동맥에서 Norepinephrine과 GTP에 의한 마이오신 인산화의 증가에 대한 Ca2+/calmodulin-dependent Protein Kinase II의 역할

안희열(Hee Yul Ahn), 김헌식(Hun Sik Kim), Robert S. Moreland 대한약리학회 대한약리학잡지 6 Pages

대한약리학회 대한약리학잡지 1994, 제 30권 제 1호 12 111-116 (6 pages)

안희열(Hee Yul Ahn), 김헌식(Hun Sik Kim), Robert S. Moreland 저
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- 3,000원
수용체작동약물과 GTP에 의한 수축단백질의 칼슘이온의 감수성의 증가에 대하여 Ca2+/calmodulin-dependent protein kinase II의 역할을 α-독으로 처리한 토끼장간막동맥에서 조사하였다. 0.3μM의 칼슘이온은 마이오신의 인산화를 시간의존적으로 증가시켰고 5분 이후부터 평형에 도달하였다. 한편, 10μM의 norepinephine과 10μM의 GTP는 칼슘이온 존재하에 칼슘이온 단독에 의한 것 보다 더 마이오신의 인산화를 증가시켰는데, 5분 후에 최대에 달하였고 그 후는 감소하기 시작하여 20분 후에는 칼슘이온 단독에 의한 마이오신...

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