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821.

Effects of Dopamine and Haloperidol on Morphine-induced CREB and AP-1 DNA Binding Activities in Differentiated SH-SY5Y Human Neuroblastoma Cells

Soo-kyungKimGee-younKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.6 3 671-676 (6 pages)

Soo-kyungKimGee-younKwon 저
...
- 3,000원
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects of morphine in differentiated SH-SY5Y human neuroblastoma cells. The increases in CREB and AP-1 DNA binding activities were time-dependent up to 6 days of morphine treatment (1, 4, and 6 days). However, the significant reduction in the DNA binding activities of CREB and...
822.

The Role of Intracellular Mg2+ in Regulation of Ca2+-activated K+ Channel in Pulmonary Arterial Smooth Muscle Cells of the Rabbit

SukHoLeeMyoungKyuPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 9 611-616 (6 pages)

SukHoLeeMyoungKyuPark 저
...
- 3,000원
Although the Ca2+-activated K+ (IK,Ca) channel is known to play an important role in the maintenance of resting membrane potential, the regulation of the channel in physiological condition is not completely understood in vascular myocytes. In this study, we investigated the role of cytoplasmic Mg2+ on the regulation of IK,Ca channel in pulmonary arterial myocytes of the rabbit using the inside-out patch clamp technique. Mg2+ increased open probability (Po), but decreased the magnitude of single...
823.

Altered Cerebral Vasomotion with Decreased CGRP Level in Pial Arteries of Spontaneously Hypertensive Rats

KwangHoLee, JaeMoonChoi, KiWhanHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 5 573-580 (8 pages)

KwangHoLee, JaeMoonChoi, KiWhanHong 저
...
- 3,000원
The study aims to identify the mechanism (s) underlying the altered vasodilatory responses of the pial artery of spontaneously hypertensive rats (SHR) under a hypothesis that calcitonin gene-related peptide (CGRP) exerts a modulator role in the autoregulation of cerebral blood flow (CBF). The animals were divided into four groups: 1) Sprague-Dawley rats (SDR), 2) Wistar rats (WR), 3) SHR with high blood pressure (BP≥150 mmHg), and 4) SHR with normotensive BP (≤150 mmHg). The lower limit of...
824.

Effect of Bromocriptine on 6-Hydroxydopamine-induced Lipid Peroxidation and Cytotoxicity in vitro and in vivo

YongSikKim, SunghoMaeng, ChanWoongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 4 565-572 (8 pages)

YongSikKim, SunghoMaeng, ChanWoongPark 저
...
- 3,000원
The present study was to evaluate the protective effects of bromocriptine, which is known as D2 dopamine receptor agonist and used for the treatment of patients with Parkinson's disease (PD), on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in vitro and in vivo. Lipid peroxidation product (malondialdehyde; MDA) produced by the administration of 6-OHDA was profoundly reduced following the treatment of bromocriptine in a dose-dependent manner in rabbit brain homogenate. Quinone formation by...
825.

Altered Renal Nitric Oxide System in Experimental Hypertensive Rats

EunSukYang, JongUnLee, DaeGillKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 7 455-460 (6 pages)

EunSukYang, JongUnLee, DaeGillKang 저
...
- 3,000원
The present study was aimed at investigating whether the development of hypertension is related with an altered expression of nitric oxide synthases (NOS) in the kidney. By Western blot analysis, the expression of bNOS and ecNOS isoforms was determined in the kidney of deoxycorticosterone acetate (DOCA)-salt and two-kidney, one clip (2K1C) rats. In DOCA-salt hypertension, the expression of both bNOS and ecNOS was decreased, along with tissue contents of nitrites. In 2K1C hypertension, the...
826.

Mechanism of Vasoactive Intestinal Polypeptide-Induced Catecholamine Secretion from the Rat Adrenal Medulla

Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 6 443-454 (12 pages)

Dong-YoonLim, Jae-BongHeo, Cheol-HeeChoi, Geon-HanLim, Yong-GyoonLee, Song-HoonOh, Il-SikKim, Jong-InKim 저
...
- 4,100원
The present study was attempted to investigate the effect of vasoactive intestinal polypeptide (VIP) on secretion of catecholamines (CA) and to establish whether there is the existence of a noncholinergic mechanism in adrenomedullary CA secretion from the isolated perfused rat adrenal gland. The perfusion into an adrenal vein of VIP (3⁓10⁣6 M) for 5 min or the injection of acetylcholine (ACh, 5.32⁓10⁣3 M) resulted in great increases in CA secretion. Tachyphylaxis to...
827.

Rapid Induction of mRNA for Prostaglandin H Synthase in Ovine Meningeal Fibroblasts

MyeongJinNam, ClaraThore, DavidBusija 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 5 435-441 (7 pages)

MyeongJinNam, ClaraThore, DavidBusija 저
...
- 3,000원
We examined effects of interleukin 1α (IL1α) and phorbol 12, 13 dibutyrate (PDB), an activator of protein kinase C, on mRNA for Prostaglandin H synthase (PGHS) and prostanoid production in cultured ovine meningeal fibroblasts. Immuno- and morphologically-identified fibroblasts were derived from cerebral cortex and white matter from fetal lambs (approximately 120 days gestation) and grown to confluence on glass coverslips in 12 well plates. Levels of prostaglandin F2α and the stable...
828.

Cytoprotective Effects of Dihydrolipoic Acid and Lipoic Acid on the Oxidative Stress in Cultured Rat Cortical Neurons

Won-KiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 4 427-433 (7 pages)

Won-KiKim 저
...
- 3,000원
a marked production of reactive oxygen species (ROS) occur in neuronal and non-neuronal cells. The present study investigated the effect of the biological antioxidants dihydrolipoic acid (DHLA) and lipoic acid (LA) on N-methyl-D-aspartate (NMDA)- and ROS-induced neurotoxicity in cultured rat cortical neurons. DHLA enhanced NMDA-evoked rises in intracellular calcium concentration ([Ca2⁢]i). In contrast, LA did not alter the NMDA-evoked calcium responses but decreased after a brief treatment...
829.

Mediation of Intracellular Ca2+ in the Phospholipase A2-induced Cell Proliferation in Human Neuroblastoma Cells

Jung-AeKimYongSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 2 411-417 (7 pages)

Jung-AeKimYongSooLee 저
...
- 3,000원
The role of phospholipase A2 (PLA2) in tumor cell growth was investigated using SK-N-MC human neuroblastoma cells. 4-Bromophenacyl bromide (BPB) and mepacrine (Mep), known PLA2 inhibitors, suppressed growth of the tumor cells in a dose-dependent manner without a significant cytotoxicity. Melittin (Mel), a PLA2 activator, enhanced the cell growth in a concentration-dependent fashion. The growth-enhancing effects of Mel were significantly reversed by the co-treatment with PLA2 inhibitors. In...
830.

Characteristic Intracelluar Response to Lidocaine And MK-801 of Hippocampal Neurons An In Vivo Intracellular Neuron Recording Study

Byung-JuChoiJin-HwaCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.3 4 297-305 (9 pages)

Byung-JuChoiJin-HwaCho 저
...
- 3,000원
This study used in vivo intracellular recording in rat hippocampus to evaluate the effect of lidocaine and MK-801 on the membrane properties and the synaptic responses of individual neurons to electrical stimulation of the commissural pathway. Cells in control group typically fired in a tonic discharge mode with an average firing frequency of 2.4⁑0.9 Hz. Neuron in MK-801 treated group (0.2 mg/kg, i.p.) had an average input resistance of 32.8⁑5.7 MΩ and a membrane time constant of...

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