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81.

Transduction of Tat-Superoxide Dismutase into Insulin-producing MIN6N Cells Reduces Streptozotocin-induced Cytotoxicity

InSoonChoung, WonSikEum, MingZhenLi, GyeSukSin, JungHoonKang, JinseuPark, SooYoungChoi, HyeokYilKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 7 163-168 (6 pages)

InSoonChoung, WonSikEum, MingZhenLi, GyeSukSin, JungHoonKang, JinseuPark, SooYoungChoi, HyeokYilKwon 저
...
- 3,000원
The reactive oxygen species (ROS) are considered to be an important mediator in pancreatic β cell destruction, thereby triggering the development of insulin-dependent diabetes mellitus. In the present study, HIV-1 Tat-mediated transduction of Cu,Zn-superoxide dismutase (SOD) was investigated to evaluate its protective potential against streptozotocin (STZ)-induced cytotoxicity in insulin-producing MIN6N cells. Tat-SOD fusion protein was successfully delivered into MIN6N cells in a...
82.

Effects of Interleukin-1β and Tumor Necrosis Factor-α on the Release of Collagenase and Gelatinase from Osteoblasts

Jong-GabEun, Dong-HeonBaek, Se-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 6 269-274 (6 pages)

Jong-GabEun, Dong-HeonBaek, Se-WonKim 저
...
- 3,000원
A large number of factors such as osteotropic hormones, cytokines, or growth factors are related to the bone remodeling which is characterized by the coupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Recent investigations have indicated that cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) play a potential role in the bone resorption associated with a variety of pathological conditions such as inflammatory osteolytic disease....
83.

Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons

Il-SungJangNorioAkaike 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 1 63-70 (8 pages)

Il-SungJangNorioAkaike 저
...
- 3,000원
Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the conventional whole-cell patch recording configuration. Muscarine (10μM) reversibly and concentration-dependently decreased mIPSC frequency without affecting the current amplitude distribution. Muscarine action on GABAergic mIPSCs was completely blocked by...
84.

G Protein-Coupled Receptor Signaling in Gastrointestinal Smooth Muscle

UyDongSohn, DongSeokKim, KarnamSMurthy 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 1 287-297 (11 pages)

UyDongSohn, DongSeokKim, KarnamSMurthy 저
...
- 4,000원
Contraction of smooth muscle is initiated by an increase in cytosolic Ca2⁢ leading to activation of Ca2⁢/ calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of Ca2⁢ and the kinetic of Ca2⁢ mobilization. Ca2⁢ mobilizing agonists stimulate different...
85.

Changes of Afferent Transmission to the SI Cortex by Transient Co-Stimulation of Receptive Field Center and Outside in Anesthetized Rats

Yu-MiYang, SabinaLim, Chung-KilWon, Hyung-CheulShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 4 27-32 (6 pages)

Yu-MiYang, SabinaLim, Chung-KilWon, Hyung-CheulShin 저
...
- 3,000원
We have characterized the aftereffects of impulse activities on the transmission of afferent sensory to the primary somatosensory (SI) cortex of the anesthetized rats (n=22). Following conditioning stimulation (CS, 10 sec, either 5 Hz or 200 Hz) to the receptive field (RF), quantitative determination of the changes of afferent sensory transmission was done by generating post-stimulus time histogram of unit response to the testing stimulation (TS, at 0.5 Hz) to the RF center (RFC) for 60 min. In...
86.

Calcium Modulates Excitatory Amino Acid (EAA)- and Substance P-induced Rat Dorsal Horn Cell Responses

HongKeeShin, SokHanKang, InDukChung, KeeSoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 5 35-45 (11 pages)

HongKeeShin, SokHanKang, InDukChung, KeeSoonKim 저
...
- 4,000원
Excitatory amino acid (EAA) and substance P (SP) have been known to be primary candidates for nociceptive neurotransmitter in the spinal cord, and calcium ions are implicated in processing of the sensory informations mediated by EAA and SP in the spinal cord. In this study, we examined how Ca2⁢ modified the responses of dorsal horn neurons to single or combined iontophoretical application of EAA and SP in the rat. All the LT cells tested responded to kainate, whereas about 55% of low...
87.

The Effects of Intracellular Monocarboxylates on the ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes

NariKim, JinHan, Eui-YongKim, Won-KyungHo, YungE.Earm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 6 581-589 (9 pages)

NariKim, JinHan, Eui-YongKim, Won-KyungHo, YungE.Earm 저
...
- 3,000원
A regulating mechanism of the ATP-sensitive potassium channels (KATP channels) is yet to fully explained. This study was carried out to investigate the effects of intracellular application of monocarboxylates (acetate, formate, lactate, and pyruvate) on KATP channels in isolated rabbit ventricular myocytes. Single channel currents of KATP channels were recorded using the excised inside-out or permeabilized attached (open-cell) patch-clamp technique at room temperature. Intracellular application...
88.

신생흰쥐 척수후근신경절 세포에서 전압의존성 K+ 전류의 동정 Characterization of Voltage-Gated Potassium Currents in Dorsal Root Ganglion Neurons of Neonatal Rats

김지목, 정승준, 김상정, 김전, JimokKim, SungJunJung, SangJeongKim, JunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 2 613-624 (12 pages)

김지목, 정승준, 김상정, 김전, JimokKim, SungJunJung, SangJeongKim, JunKim 저
...
- 4,100원
Dorsal root ganglion (DRG) is composed of neuronal cell bodies of primary afferents with diverse functions. Various types of ion channels present on DRG neurons may reflect those functions. In the present study, voltage-gated potassium currents in DRG neurons of neonatal rats were characterized by whole-cell voltage clamp method. Two types of delayed rectifier and three types of transient potassium currents were identified according to their electrophysiological properties. The delayed...
89.

중추내로 투여한 5-HT1A 작동제에 의한 마취 가토에 있어서 신장기능의 변동 Renal Functional Responses to a Centrally-administered 5-HT1A Agonist in the Anesthetized Rabbits

임영채, 김경심, 국영종, 고정태, YoungChaiLim, KyungShimKim, YoungJohngKook, JeongTaeKoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.3 10 315-323 (9 pages)

임영채, 김경심, 국영종, 고정태, YoungChaiLim, KyungShimKim, YoungJohngKook, JeongTaeKoh 저
...
- 3,000원
Central tryptaminergic system has been shown to play an important role in the regulation of renal function: 5-HT1(5-hydroxytryptamine1) receptors might seem to mediate the diuresis and natriuresis, whereas the 5-HT2 and 5-HT3 receptors mediate the antidiuretic and antinatriuretic effects. This study attempted to delineate the role of central 5-HT1A subtype in the regulation of rabbit renal function by observing the renal effects of intracerebroventricularly(icv)-administered...
90.

Risperidone이 백서의 Schedule-Induced Polydipsia에 미치는 영향

이기철, 이정호, 윤도준, 최영민, 전성일, 김태수, 정홍경, 하준명, 정재현 대한신경정신의학회 신경정신의학 9 Pages

대한신경정신의학회 신경정신의학 2000, 제 39권 제 3호 13 620-628 (9 pages)

이기철, 이정호, 윤도준, 최영민, 전성일, 김태수, 정홍경, 하준명, 정재현 저
...
- 3,000원
연구목적： 강박장애의 원인론중 세로토닌–도파민 가설에 기초하여 강박장애 동물모형으로 고려되는 고정된 시간 간 격으로 평소의 먹이 섭취량보다 작은 양의 음식물을 백서에게 장기간 공급하여 다음증(schedule-induced polydipsia；SIP)을 유발시켰다. SIP 모형에 강박장애에 효과적이라고 알려진 선택적 세로토닌 재흡수 차단 제로서 fluoxetine을 장기 투여하고, 신경절후 5-HT2와 도파민 D2 수용체를 동시에 차단하는 risperidone 을 투여하고, 신경절후 도파민 수용체 차단제인 haloperidol을 투여하였다. 그 결과로서...

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