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81.

Glycyrrhizin Attenuates MPTP Neurotoxicity in Mouse and MPP+-Induced Cell Death in PC12 Cells

YunJeongKim, ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.2 5 65-72 (8 pages)

YunJeongKim, ChungSooLee 저
...
- 3,000원
on the 1-methyl-4-phenylpyridinium (MPP+)-induced cell death in differentiated PC12 cells. MPTP treatment increased the activities of total superoxide dismutase, catalase and glutathione peroxidase and the levels of malondialdehyde and carbonyls in the brain compared to control mouse brain. Co-administration of glycyrrhizin (16.8 mg/kg) attenuated the MPTP effect on the enzyme activities and formation of tissue peroxidation products. In vitro assay, licorice compounds attenuated the MPP+-induced...
82.

Involvement of Endoplasmic Reticulum Stress Response in the Neuronal Differentiation

YoonMiCho, YoonSeongJang, Young-MinJang, Jin-YoungSeo, HoShikKim, JeongHwaLee, SeongWhanJeong, InKyungKim, Oh-JooKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.6 2 239-248 (10 pages)

YoonMiCho, YoonSeongJang, Young-MinJang, Jin-YoungSeo, HoShikKim, JeongHwaLee, SeongWhanJeong, InKyungKim, Oh-JooKwon 저
...
- 3,000원
of endoplasmic reticulum stress response (ERSR) genes were examined during the neuronal differentiation of rat fetal cortical precursor cells (rCPC) and rat pheochromocytoma PC12 cells. When rCPC were differentiated into neuronal cells for 7 days, early stem cell marker, nestin, expression was decreased from day 4, and neuronal markers such as neurofilament-L, -M and Tuj1 were increased after day 4. In this condition, expressions of BIP, ATF6, and phosphorylated PERK as well as their down stream...
83.

Protein Kinase C-mediated Neuroprotective Action of (－)-epigallocatechin-3-gallate against Aβ1-42-induced Apoptotic Cell Death in SH-SY5Y Neuroblastoma Cells

SujeongJang, KyoungWanYou, Song-HeeKim, SungJunPark, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 1 163-169 (7 pages)

SujeongJang, KyoungWanYou, Song-HeeKim, SungJunPark, Han-SeongJeong, Jong-SeongPark 저
...
- 3,000원
in SH-SY5Y human neuroblastoma cells. One μM Aβ1-42 decreased cell viability, which was correlated with increased DNA fragmentation evidenced by DAPI staining. Pre-treatment of SH-SY5Y neuroblastoma cells with EGCG (1μM) significantly attenuated Aβ1-42-induced cytotoxicity. Potential cell signaling candidates involved in this neuroprotective effects were further examined. EGCG restored the reduced PKC, ERK, and JNK activities caused by Aβ1-42 toxicity. In addition, gene expression analysis...
84.

Comparison of Inhibitory Potency of Various Antioxidants on the Activation of BV2 Microglial Cell Lines Induced by LPS

Pil-JaeKong, Jong-IkPark, Oh-YoonKwon, YoonHeeHan, SooYoungKim, SuNamLee, HeeJeongSon, Sung-SooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 2 9-13 (5 pages)

Pil-JaeKong, Jong-IkPark, Oh-YoonKwon, YoonHeeHan, SooYoungKim, SuNamLee, HeeJeongSon, Sung-SooKim 저
...
- 1,500원
in the BV2 microglial cell line. Lipopolysaccharide (LPS) (0.2μg/ml) was used with or without antioxidants to treat cells, and the regulation of iNOS and cytokine gene expression was monitored using an RNase protection assay (RPA). Although, all tested antioxidants had similar DPPH-reducing activity and inhibited nitrite production, but the curcuminoid antioxidants (ferulic acid, caffeic acid, and curcumin) inhibited LPS-induced gene expression (iNOS, TNF-α, IL-1β, IL-6, and IL-1 Ra) in a...
85.

Baicalein Protects 6-OHDA-induced Neuronal Damage by Suppressing Oxidative Stress

Heh-InIm, EunjooNam, Eun-sunLee, Yu-jinHwang, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 3 309-316 (8 pages)

Heh-InIm, EunjooNam, Eun-sunLee, Yu-jinHwang, YongSikKim 저
...
- 3,000원
The protective effects of baicalein, one of the flavonoids in Scutellaria baicalensis Georgi, were evaluated against 6-hydroxydopamine (6-OHDA)-induced neuronal damage in mice and cultured human neuroblastoma cells. Nigrostriatal damage was induced by stereotaxically injecting 6-OHDA into the right striatum. Baicalein was administered intraperitoneally 30 min before and 90 min after lesion induction. Animals received a further daily injection of baicalein for 3 consecutive days. Two weeks after...
86.

Effects of Ethosuximide on the Pilocarpine Induced Seizure in Rat Model of Neuronal Migration Disorder

Byung-KonKim, In-SunChoi, Jin-HwaCho, Il-SungJang, Maan-GeeLeeByung-JuChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 3 235-242 (8 pages)

Byung-KonKim, In-SunChoi, Jin-HwaCho, Il-SungJang, Maan-GeeLeeByung-JuChoi 저
...
- 3,000원
Cortical malformation-associated epileptic seizures are resistant to conventional anticonvulsant drugs. Relatively little research has been conducted on the effects of antiepileptic drugs (AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate (MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of ethosuximide (ETX) in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed...
87.

Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells

DongHeeLee, ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.1 9 51-57 (7 pages)

DongHeeLee, ChungSooLee 저
...
- 3,000원
the cytotoxicity of MPP⁢ against PC12 cells. H2O2 may enhance the MPP⁢-induced viability loss in PC12 cells by promoting the mitochondrial membrane permeability change, release of cytochrome c and subsequent activation of caspase-3, which is associated with the increased formation of ROS and depletion of GSH. The findings suggest that H2O2 as a promoting agent for the formation of mitochondrial permeability transition may enhance the neuronal cell injury caused by neurotoxins.
88.

Differential Inhibition of MPP+- or 6-Hydroxydopamine-induced Cell Viability Loss in PC12 Cells by Trifluoperazine and W-7

ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 9 247-252 (6 pages)

ChungSooLee 저
...
- 3,000원
and W-7 (a specific calmodulin antagonist) significantly attenuated the MPP⁢- induced cell viability loss in PC12 cells with a maximum inhibition at 0.5∼1μM; beyond these concentrations the inhibitory effect declined. Both compounds at this concentration range did not cause cell death significantly. In contrast to MPP⁢, the trifluoperazine and W-7 did not depress the cytotoxic effect of 6-OHDA. Addition of trifluoperazine and W-7 inhibited the cytosolic accumulation of cytochrome c...
89.

Inhibition of Nitric Oxide-induced Neuronal Apoptosis in PC12 Cells by Epigallocatechin Gallate

JiYeonJung, YeonJinJeong, ChangRyoungHan, SunHunKim, HyunJinKim, KiHeonLee, HaOkPark, WonJaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 8 239-246 (8 pages)

JiYeonJung, YeonJinJeong, ChangRyoungHan, SunHunKim, HyunJinKim, KiHeonLee, HaOkPark, WonJaeKim 저
...
- 3,000원
a major compound of green tea, is recognized as protective substance against neuronal diseases. This study is aimed to investigate the effect of EGCG on NO-induced cell death in PC12 cells. Administration of sodium nitroprusside (SNP), a NO donor, decreased cell viability in a dose- and time-dependent manner and induced genomic DNA fragmentation with cell shrinkage and chromatin condensation. EGCG diminished the decrement of cell viability and the formation of apoptotic morphologenic changes as...
90.

Effects of a δ-opioid Agonist on the Brainstem Vestibular Nuclear Neuronal Activity of Rats

Tae-SunKim, MeiHuang, Myung-JooJang, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.3 1 137-142 (6 pages)

Tae-SunKim, MeiHuang, Myung-JooJang, Han-SeongJeong, Jong-SeongPark 저
...
- 3,000원
patch-clamp techniques. The spontaneous action potentials were increased by DADLE in 12 cells and decreased in 3 cells. The spike frequency and resting membrane potential of these cells were increased by DADLE. The depth of afterhyperpolarization was not affected by DADLE. The potassium currents were decreased in 20 cells and increased in 5 cells. These results suggest that DADLE increases the neuronal activity of the medial vestibular nuclear neurons by altering resting membrane potential.

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