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전체 선택해제
총 154건 검색
본문검색 결과만 보기
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Inhibition of Pacemaker Activity of Interstitial Cells of Cajal by Hydrogen Peroxide via Activating ATP-sensitive K+ Channels
SeokChoi, ShankarPrasadParajuli, HyeonSookCheong, DilliParasadPaudyal, CheolHoYeum, PyungJinYoon, JaeYeoulJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 3 15-20 (6 pages)
ICC, H2O2 hyperpolarized the membrane potential under currents clamp mode and decreased both the frequency and amplitude of pacemaker currents and increased the resting currents in outward direction under voltage clamp mode. Also, H2O2 inhibited the pacemaker currents in a dose-dependent manner. Because the properties of H2O2 action on pacemaker currents were same as the effects of pinacidil (ATP-sensitive K channels opener), we tested the effects of glibenclamide (ATP-sensitive K... -
The Role of Mitochondrial ATP-sensitive Potassium Channel on Intestinal Pacemaking Activity
ByungJooKim, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.4 4 209-214 (6 pages)
glibenclamide, an inhibitor of the ATP sensitive K channels, we could find two examples. If pacemaking activity of ICCs was irregulating, pacemaking activity of ICCs was changed into regulating and if in normal conditions, membrane potential amplitude was increased. At 50μM glibenclamide, the resting membrane potential was depolarized. At 3mM 5-HDA, an inhibitor of the mitoKATP channels, inhibited the pacemaking activity of ICCs. Both the amplitude and the frequency were decreased. At 5... -
Thiol-dependent Redox Mechanisms in the Modification of ATP-Sensitive Potassium Channels in Rabbit Ventricular Myocytes
JinHan, NariKim, DangVanCuong, ChunghuiKim, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 4 15-23 (9 pages)
However, in the patches excised from the metabolically compromised cells, DTT increased the channel activity. DTT had no effect on the inhibitory action by ATP, showing that thiol oxidation was not involved in the blocking mechanism of ATP. There were no statistical difference in the single channel conductance for the oxidized and reduced states of the channel. Analysis of the open and closed time distributions showed that DTNB had no effect on open and closed time distributions shorter than 4... -
Identification of ATP-sensitive K+ Conductances in Male Rat Major Pelvic Ganglion Neurons
Kyu-SangPark, Seung-KyuCha, Keon-IlLee, JaeYeoulJun, Seong-WooJeong, InDeokKong, JoongWooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 3 247-254 (8 pages)
to the electrophysiological properties; membrane capacitance (Cm), expression of T-type Ca2 channels, and the firing patterns during depolarization. In the present study, function and molecular expression of ATP-sensitive K (KATP) channels was investigated in MPG neurons of male rats. Only in parasympathetic MPG neurons showing phasic firing patterns, hyperpolarizing changes were elicited by the application of diazoxide, an activator of KATP channels. Glibenclamide (10μM), a KATP... -
Activation of ATP-sensitive Potassium Channels by the Predominant Metabolite of Isoflurane in Rabbit Ventricular Myocytes
JinHan, NariKim, EuiyongKim, SungjuKim, KangheeCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 7 165-175 (11 pages)
increased burst duration and decreased the interburst interval without changes in open and closed time distributions shorter than 5 ms. TFA diminished ATP sensitivity of KATP channels in a concentration-response relationship for ATP. Conclusions: TFA, a metabolite of isoflurane, enhanced KATP channel activity in a concentration-dependent fashion. These results imply that TFA could mediate isoflurane-induced cardioprotection via KATP channel activation during myocardial ischemia and reperfusion. -
Evidence for Adenosine Triphosphate (ATP) as an Excitatory Neurotransmitter in Guinea-Pig Gastric Antrum
TongMookKang, WenxieXu, SungJoonKim, SeungCheolAhn, YoungChulKim, InsukSo, MyoungKyuPark, Dae-YongUhm, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 6 165-174 (10 pages)
(ATP) acts as an excitatory neurotransmitter in guinea-pig gastric smooth muscle. In an organ bath system, isometric force of the circular smooth muscle of guinea-pig gastric antrum was measured in the presence of atropine and guanethidine. Under electrical field stimulation (EFS) at high frequencies (＞20 Hz), NO-mediated relaxation during EFS was followed by a strong contraction after the cessation of EFS (a "rebound-contraction"). Exogenous ATP mimicked the rebound-contraction. A... -
The Effects of Intracellular Monocarboxylates on the ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes
NariKim, JinHan, Eui-YongKim, Won-KyungHo, YungE.Earm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 6 581-589 (9 pages)
of the ATP-sensitive potassium channels (KATP channels) is yet to fully explained. This study was carried out to investigate the effects of intracellular application of monocarboxylates (acetate, formate, lactate, and pyruvate) on KATP channels in isolated rabbit ventricular myocytes. Single channel currents of KATP channels were recorded using the excised inside-out or permeabilized attached (open-cell) patch-clamp technique at room temperature. Intracellular application of acetate, formate and... -
콘크리트 슬래브궤도에서 철근이 ATP시스템 지상자의 주파수에 미치는 영향
김민석, 윤인모, 고준석, 이종우, Kim. Min-Seok, Yoon. In-Mo, Ko. Jun-Seog, Lee. Jong-Woo 한국철도학회 한국철도학회 논문집 7 Pages
한국철도학회 한국철도학회 논문집 2008, Vol.11 No.6 536-542 (7 pages)
신호에 의해서 열차의 차상자에 잘못된 신호가 전송될 수 있다. 입력전류신호의 왜곡을 줄이기 위한 방법으로 철근에 유도되는 전류와 주파수를 구하여 해당 주파수를 ATP시스템의 지상자 주파수로 사용하지 않거나, 철근을 절연시켜 철근과 ATP시스템 지상자간에 유도현상을 억제할 수 있다. 본 논문에서는 콘크리트 슬래브궤도에서 ATP시스템의 지상자와 철근의 모델을 전기적으로 표현하였고, 모델에 요구되는 값들을 Maxwell 프로그램을 이용하여 구하였다. 또한 모델로부터 ATP시스템인 KVB시스템, ERTMS/ETCS시스템에서 사용하고...
